Combined bullous pemphigoid and pemphigus vulgaris in an 18‐year‐old female

Rossi, Anthony; Reszko, Anetta E.; Leach, James; Magro, Cynthia M.

doi:10.1111/j.1600-0560.2009.01360.x

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…Our data support this concept of autoimmune diathesis in PV, as patients have a higher frequency of autoimmune disease in general relative to the U.S. population. Previous studies have proposed an association between PV and a number of autoimmune diseases . However, there is no consensus as to whether particular autoimmune diseases are more commonly associated with PV.…”

Section: Discussionmentioning

confidence: 99%

“…There have been a number of reports in the literature concerning the association and clustering between different autoimmune diseases . Several case reports and studies have reported associations between PV and a number of individual autoimmune diseases . However, there is a lack of consensus as to whether these are sporadic disease associations or part of a pattern of concomitant autoimmune diseases that may form distinct clusters.…”

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confidence: 99%

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Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes

et al. 2015

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes

et al. 2015

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“…Adolescence is a hormonally driven period of development during which physiologic, cognitive, and psychosocial functioning changes foster the transition from childhood to adulthood. It is divided into three phases: early (10-13 years of age), middle (14)(15)(16)(17), and late adolescence (18)(19)(20)(21). 3 All published data were reviewed according to these phases of adolescence.…”

Section: Definitionsmentioning

confidence: 99%

Bullous pemphigoid in adolescence

Patsatsi

Kyriakou

Werth

2018

Pediatric Dermatology

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Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10‐13 years), middle (14‐17), and late (18‐21). This review aimed to identify BP cases in adolescence and demonstrate their clinical features and course. Our literature search was performed in Medline with the terms “bullous pemphigoid in childhood and adolescence,” “childhood bullous pemphigoid,” “juvenile bullous pemphigoid,” and “autoimmune blistering and autoimmune bullous diseases in childhood.” The data extraction for late adolescence was limited by the fact that this age group is included in adult BP registries. We identified nine cases in early adolescence. Mucosa were affected in 5 of 9 cases. Treatment consisted of systemic prednisone (8/9), in combination with dapsone (2/9), azathioprine (2/9), or erythromycin/nicotinamide (1/9). Relapses were reported in 3 of 9 cases. We identified five cases occuring in middle adolescence. Mucosa were not affected. Treatment consisted of systemic prednisone (5/5), in combination with dapsone (3/5), azathioprine (2/5), doxycycline/nicotinamide (1/5), or mycophenolate mofetil (1/5). Relapses were reported in two of five cases. No case of BP in the late adolescence was included in the results, as only one case met the search criteria, and overlapped with pemphigus vulgaris. With only 14 cases found in our review, BP in adolescence appears even rarer than in earlier childhood. Despite its low prevalence, BP should be included in the differential diagnosis of autoimmune blistering diseases in adolescents.

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“…Further, few cases with antibodies to the intercellular space (ICS) and basement membrane zone (BMZ) have been reported, [1][2][3] especially with both immunoglobulin (Ig)G and IgA antibodies. Further, few cases with antibodies to the intercellular space (ICS) and basement membrane zone (BMZ) have been reported, [1][2][3] especially with both immunoglobulin (Ig)G and IgA antibodies.…”

Section: Introductionmentioning

confidence: 99%

“…Pemphigus and pemphigoid are two distinct groups of autoimmune blistering diseases, and both diseases rarely occur at the same time in the same patient. Further, few cases with antibodies to the intercellular space (ICS) and basement membrane zone (BMZ) have been reported, [1][2][3] especially with both immunoglobulin (Ig)G and IgA antibodies. 4,5 In this report, we describe a highly rare case of pemphigus vulgaris (PV) with IgG and IgA bound to both the ICS and BMZ.…”

Section: Introductionmentioning

confidence: 99%

Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone

Hosoda

Adachi

Suzuki

et al. 2015

The Journal of Dermatology

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We report a case involving a 62-year-old woman with in vivo-bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo-bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti-ICS IgG bound to desmoglein-3, while the anti-BMZ antibodies bound to the epidermal side of 1 mol/L NaCl-split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo-bound and circulating anti-ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti-ICS antibodies belonged to IgG1 and IgG4, while the circulating anti-BMZ antibodies to IgG1, IgG2 and IgG4. We report a case involving a 62-year-old woman with in vivo-bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo-bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti-ICS IgG bound to desmoglein-3, while the anti-BMZ antibodies bound to the epidermal side of 1 mol/L NaCl-split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo-bound and circulating anti-ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti-ICS antibodies belonged to IgG1 and IgG4, while the circulating anti-BMZ antibodies to IgG1, IgG2 and IgG4.

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Combined bullous pemphigoid and pemphigus vulgaris in an 18‐year‐old female

Cited by 6 publications

References 32 publications

Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes

Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes

Bullous pemphigoid in adolescence

Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone

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