Combined Central and Peripheral Demyelinating Disease With Good Response to B-Cell Depleting Therapy

Recovery of Chronic Inflammatory Demyelinating Polyneuropathy on Treatment With Ocrelizumab in a Patient With Co-Existing Multiple Sclerosis

“… 7 , 8 One case of successful treatment of CCPD with rituximab has been published so far. 9 Contrary to most case reports about CCPD our patient did not simultaneously develop peripheral and central demyelination so that both CIDP and MS were independently diagnosed at different time points. Both, the diagnostic criteria for CIDP 5 and MS 6 were fulfilled in this case.…”

Post COVID vaccination combined central and peripheral demyelination: Case series and review

“…Importantly, application of individual diagnostic criteria does not cover the entire spectrum seen in a patient. Our cases highlight red flags for pure PNS involvement like sensory level and sphincter involvement that may suggest added CNS insult [8,10,13]. Also, sequential involvement may occur as in Case 3 [6,12].…”

“…Most cases of CCPD are single reports or series, the largest comprising of 40 patients, exemplifying its rarity. Table 1 shows the clinical characteristics of patients reported in world literature [1][2][3][4][5][6][7][8][9][10][11][12][13]. Infections constitute majority of known triggers of CCPD, which rarely follows influenza and pneumococal vaccination.…”

“…However, we noted good response to IVMP in CO-VID vaccination related CCPD, failing which PLEX was effective [11][12][13]. There are also reports of halting of disease progression with rituximab [9,10].…”