Combined chemotherapy and radiation therapy for head and neck malignancies

Nguyen, Nam P.; Sallah, Sabah; Karlsson, Ulf; Antoine, John E.

doi:10.1002/cncr.10257

Cited by 199 publications

(188 citation statements)

References 77 publications

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“…[1][2][3] If a less than-desired dose is used to reduce damage to healthy tissues, it may result in diminished quality of life and higher morbidity rate for these individuals. 3 In radiation therapy for head and neck cancer, the major salivary glands often receive a high radiation dose. Acute and chronic responses displayed by salivary glands after radiation are related to dose of radiation and the amount of the glands in the direct line of the beam.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Protective Effect of Propolis on Parotid Salivary Glands in Gamma-irradiated Rats

Mina

Abedi

Seyedmajidi

et al. 2014

The Journal of Contemporary Dental Practice

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Objective and background: One of the most significant side effects of radiotherapy for head and neck cancers is xerostomia as a result of salivary gland damage. Considering pharmacological effects of propolis, we evaluated its protective effect on salivary glands subjected to radiotherapy of head and neck cancer patients. Materials and methods:Twenty-one male albino rats (8-11 W, 190 ± 5 gm) were divided into three groups of seven animals. Scintigraphy was performed in all the groups. Then groups 1 (S) and 2 (SR) received normal saline injections and group 3 (PR) received propolis injection over 3 days. After that groups 2 and 3 were exposed to gamma radiation and all the rats underwent scintigraphic assessment on third day and 70th day after irradiation. The lips and tongues of rats in groups 2 and 3 were examined for mucositis daily in first 10 days. At the end, the parotid glands of all rats were examined histologically.Results: Scintigraphy results of third and 70th day after irradiation showed statistically significant differences between PR and SR as well as SR and S. However, there was no significant difference between the PR and S groups. Histopathologic assessment demonstrated significant difference between SR, PR and S. Original research Conclusion:These results suggest that propolis has protective effects on salivary gland function in animal models whilst it did not prevent radiation-induced histologic changes in tissues. Further investigations are needed to elucidate mechanisms of propolis actions.Clinical significance: Regarding to the results of this study, propolis may be useful in reduction xerostomia due to radiation to salivary glands and may be helpful for head and neck cancer patients.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Protective Effect of Propolis on Parotid Salivary Glands in Gamma-irradiated Rats

Mina

Abedi

Seyedmajidi

et al. 2014

The Journal of Contemporary Dental Practice

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“…The EORTC QLQ-H&N35 is widely used to measure quality of life in H&N cancer patients (Singer et al, 2013). Both prospective and cross-sectional studies (Bjordal et al, 2001;Hammerlid et al, 2001aHammerlid et al, , 2001bHammerlid et al, , 2001cNguyen et al, 2002;Talmi et al, 2002;Shepherd and Fisher, 2004) have documented reductions in HRQOL in populations of H&N cancer patients who have received RT. Several studies have also examined changes in HRQOL during the treatment period (Bjordal et al, 2001;Henson et al, 2001; Airolldi et al, 2004;Parliament et al, 2004;Jabbari et al, 2005; Braam et al, 2007; Curran et al, 2007; Ackerstaff et al, 2009; Ackerstaff et al, 2012;Maguire et al, 2011;Maurer et al, 2011;Nutting et al, 2011).…”

mentioning

confidence: 99%

Changes in health related quality of life in women and men undergoing radiation treatment for head and neck cancer and the impact of smoking status in the radiation treatment period

Egestad

Emaus

2014

European Journal of Oncology Nursing

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Abstract:Purpose The aim of this study was to evaluate health-related quality of life (HRQOL) in women and men undergoing radiation treatment for head and neck cancer through the intervention period and examine if age, body mass index (BMI) and smoking status at baseline may modify changes in HRQOL. Results Most aspects of HRQOL declined substantially and significantly (p<0.001) with a magnitude of more than one standard deviation during the radiation treatment period irrespective of sex and age. Smoking status at baseline had some, albeit minor, influence on changes in HRQOL. Patients who continued smoking during therapy had significantly higher decline in several aspects of HRQOL, compared to patients who stopped smoking.Conclusions HRQOL decline with substantial magnitude in patients undergoing radiation treatment for head and neck cancer, but smoking cessation may modify the declining quality of life. IntroductionTreatments of head and neck (H&N) cancer include surgery, radiotherapy (RT), chemotherapy, target therapy or a combination of these modalities. The diagnosis and the following treatment may exert a severe impact on patient's quality of life (QOL) (So et al., 2012). The malignancy affects the most visible area of the body, and may influence the most fundamental activities of daily life in a negative way, such as speech, breathing, eating and drinking (Larsson and Hedelin, 2003;Wells 1998). H&N cancer patients' illness often involves physical symptoms, psychological distress, as well as side effects from RT (Archer et al., 2008). The treatment can result in dry mouth (xerostomia), oral discomfort, mucositis, recurrent microbial infections, difficulty in chewing and swallowing, increased incidence of dental caries, impaired taste, and an inability to wear dentures (Parsons et al., 1994). In addition, depression is reported to increase in H&N cancer patients undergoing RT (Neilson et al., 2010;Kelly et al., 2007).The interest in health-related quality of life (HRQOL) (i.e. the physical, mental, and social functioning and well-being) in H&N cancer patients has increased over the two decades (So et al., 2012). Even if the most important outcome for cancer patients is overall survival, the disease and its treatment often have a major impact on HRQOL and functional status (List et al., 2002). Reliable and valid HRQOL questionnaires are available (Aaronson et al., 1993; Bjordal et al., 2000;Ringash and Bezjak, 2001). The EORTC QLQ-H&N35 is widely used to measure quality of life in H&N cancer patients (Singer et al., 2013). Both prospective and cross-sectional studies (Bjordal et al., 2001;Hammerlid et al., 2001aHammerlid et al., , 2001bHammerlid et al., , 2001cNguyen et al., 2002;Talmi et al., 2002;Shepherd and Fisher, 2004) have documented reductions in HRQOL in populations of H&N cancer patients who have received RT. Several studies have also examined changes in HRQOL during the treatment period (Bjordal et al., 2001;Henson et al., 2001; Airolldi et al., 2004;Parliament et al., 2004;Jabbari et al., 2...

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“…These treatments therefore have the potential to substantially diminish QoL and may cause many patients to prematurely stop taking medication, resulting in treatment failure. 46,47 A QoL analysis of a phase III trial comparing high-dose radiotherapy with or without concomitant cetuximab 48 concluded that the addition of cetuximab to radiotherapy significantly improved locoregional control and increased overall survival without having any significant effects on QoL. In this study, compliance with completing QoL questionnaires was high and the data are therefore considered to be reliable.…”

Section: Quality Of Lifementioning

confidence: 84%