Combined chemotherapy and radiotherapy followed by surgery in the treatment of patients with squamous cell carcinoma of the esophagus

Adham, Mustapha; Baulieux, J.; Mornex, F.; Ducerf, C.; Jc, Souquet; Jp, Gérard

doi:10.1002/1097-0142(20000901)89:5<946::aid-cncr2>3.0.co;2-3

Cited by 41 publications

(9 citation statements)

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“…This enthusiasm has been tempered by the observed incidence of PARCs, which in some studies 8,9,19,23,24 has been significantly increased, while in others 6,25,26 appears to be quite similar to what is seen after esophagectomy alone. It remains unclear which patient is most likely to acquire a postoperative pulmonary complication after this kind of treatment.…”

Section: Discussionmentioning

confidence: 99%

Impact of Induction Concurrent Chemoradiotherapy on Pulmonary Function and Postoperative Acute Respiratory Complications in Esophageal Cancer

Abou-Jawde

Mekhail

Adelstein

et al. 2005

Chest

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Section: Discussionmentioning

confidence: 99%

Impact of Induction Concurrent Chemoradiotherapy on Pulmonary Function and Postoperative Acute Respiratory Complications in Esophageal Cancer

Abou-Jawde

Mekhail

Adelstein

et al. 2005

Chest

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“…The disease is characterized by late clinical presentation, rapid progression, and poor survival [2]. Despite improvements in its detection, surgical techniques, and chemoradiotherapy, the overall survival of esophageal carcinoma remains low [3][4][5][6]. Actually, no ideal prognosis and long-term survival can be obtained for patients with progressing ESCC and no significant progress has occurred in treatment.…”

Section: Introductionmentioning

confidence: 99%

Decreased Expression of CIAPIN1 Is Correlated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

et al. 2010

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“…In the analysis of the survival of this particular group of patients, we observed a 5-year survival rate of 54% for T0-stage patients and signifi cantly higher than that for those with low responses to preoperative treatment. Indeed, the work by Adham et al and Laterza et al [27,28] in patients with oesophageal squamous cell carcinoma found higher 5-year survival rates in patients with good response to treatment (34.9% and 53%) vs. those in which there was no response (10.7% and 0%).…”

Section: Discussionmentioning

confidence: 97%

Transthoracic oesophagectomy with lymphadenectomy in 100 oesophageal cancer patients. Multidisciplinary approach

et al. 2011

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OBJECTIVES Analysis of the results on the treatment of esophageal cancer by transthoracic esophagectomy by a multidisciplinary team of surgeons and oncologists. METHODS Between January 1990 and December 2009, 100 consecutive patients underwent transthoracic esophagectomy. Data were collected prospectively and clinical, pathological and histological features of the tumors were analyzed as well as the results of postoperative morbidity and mortality. RESULTS The average patient age was 55 years (range 31- 83 years). In 59 cases the tumor was located in the lower third and in 41 cases in the middle third. Forty-six patients had adenocarcinoma and 54 squamous cell carcinoma. In 54 cases radio-chemotherapy was planned preoperatively. Classifi cation according to pathological tumor stage was: stage 0 in 21 patients, stage I in 10 patients, stage IIa in 28, stage IIb in 9, stage III in 21 and stage IV in 11. The mean number of lymph nodes examined was 14 (range 0-28). Hospital mortality occurred in 4 cases and postoperative complications in 29 patients (33%). The most frequent postoperative complication was pulmonary complications in 17 cases. The average hospital stay was 15.2 days (range 10-40 days) CONCLUSIONS The results of esophageal cancer have been improved in recent years due to the formation of multidisciplinary teams in this pathology. In our study we have shown that the results obtained with the transthoracic technique for cancer of the esophagus are within the ranges reported in the literature for teams with high prevalence of the disease.

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Combined chemotherapy and radiotherapy followed by surgery in the treatment of patients with squamous cell carcinoma of the esophagus

Cited by 41 publications

References 50 publications

Impact of Induction Concurrent Chemoradiotherapy on Pulmonary Function and Postoperative Acute Respiratory Complications in Esophageal Cancer

Impact of Induction Concurrent Chemoradiotherapy on Pulmonary Function and Postoperative Acute Respiratory Complications in Esophageal Cancer

Decreased Expression of CIAPIN1 Is Correlated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Transthoracic oesophagectomy with lymphadenectomy in 100 oesophageal cancer patients. Multidisciplinary approach

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