Combined Contrast-Enhanced Computed Tomography and 18-Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography in the Diagnosis and Staging of Non-small Cell Lung Cancer

Allen, Tadashi; Kendi, Ayşe Tuba Karagülle; Mitiek, Mohi O.; Maddaus, Michael A.

doi:10.1053/j.semtcvs.2011.05.003

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…35 Finally, it could be argued that our analysis would inherently favor the SUV ratio over SUV max simply because a variety of scanners at different imaging centers were included in this study, and the performance of SUV max is disproportionately affected by the scanner hardware and reconstruction approaches. Indeed, it has been shown that while absolute SUV measurements can vary by 15-20% between centers, [11][12][13][14]36 the SUV ratio is relatively insensitive to the PET protocol used. [24][25] This is actually one of the main advantages to using an SUV ratio, as considerable variation in PET/CT methodology is common in both the United States and internationally even among academic medical centers.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…Additionally, while SUV is standardized for a patient's weight and the amount of FDG administered, it does not take into account a plethora of other patient, tumor, and technique-specific factors, which contribute to a measured variability in the absolute SUV on the order of 10-20%. [11][12][13][14] Patient-specific factors that affect tumor uptake include body composition and habitus, plasma glucose level, and respiratory rate. Techniquespecific factors include the time from tracer injection to scanning, interscanner variability, reconstruction parameter changes, use of contrast, and interobserver variability.…”

Section: Introductionmentioning

confidence: 99%

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Ratio of Lymph Node to Primary Tumor SUV on PET/CT Accurately Predicts Nodal Malignancy in Non–Small-Cell Lung Cancer

Mattes

Moshchinsky

Ahsanuddin

et al. 2015

Clinical Lung Cancer

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ratio of Lymph Node to Primary Tumor SUV on PET/CT Accurately Predicts Nodal Malignancy in Non–Small-Cell Lung Cancer

Mattes

Moshchinsky

Ahsanuddin

et al. 2015

Clinical Lung Cancer

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“…A diagnostic effectiveness of PET/CT for staging NSCLC and superiority to conventional cancer imaging modalities has been demonstrated by many studies [18, 20, 50, 51]. However, whether this technology should be widely applied in the staging of NSCLC remains at debate for its high examination costs.…”

Section: The Cost-effectiveness Of Pet/ct In Nsclc Stagingmentioning

confidence: 99%

PET/CT in the Staging of the Non-Small-Cell Lung Cancer

Chao

Zhang

2012

Journal of Biomedicine and Biotechnology

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Lung cancer is a common disease and the leading cause of cancer-related death in many countries. Precise staging of patients with non-small-cell lung cancer plays an important role in determining treatment strategy and prognosis. Positron emission tomography/computed tomography (PET/CT), combining anatomic information of CT and metabolic information of PET, is emerging as a potential diagnosis and staging test in patients with non-small-cell lung cancer (NSCLC). The purpose of this paper is to discuss the value of integrated PET/CT in the staging of the non-small-cell lung cancer and its health economics.

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“…[2–8] The reasons for this wide range included the study of different patient populations, varying criteria for malignancy, and patient-, tumor-, and technique-specific factors. [9,10] …”

Section: Introductionmentioning

confidence: 99%

Ratio of lymph node to primary tumor SUVmax multiplied by maximal tumor diameter on positron emission tomography/integrated computed tomography may be a predictor of mediastinal lymph node malignancy in lung cancer

et al. 2016

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Positron emission tomography/integrated computed tomography (PET/CT) provides the most accurate imaging modality for preoperative lung cancer staging. However, the diagnostic accuracy of maximum standardized uptake value (SUVmax) for mediastinal (N2) lymph nodes (LN) is unclear. We compared SUVmax, the ratio of LN to primary tumor SUVmax (SUVn/t), and SUVn/t multiplied by maximal tumor diameter (SUVindex) in terms of their abilities to predict mediastinal LN malignancy.We retrospectively analyzed 170 mediastinal LN stations from 73 consecutive patients who underwent systemic LN resection and PET/CT within 27 days. The SUVmax of the primary tumors was >2.0 and the SUVmax of the mediastinal LN stations ranged from 2.0 to 7.0 on PET/CT. Receiver-operating characteristic curves (ROCs) of SUVmax, SUVn/t, and SUVindex were calculated separately and the areas under the curves (AUCs) were used to assess the abilities of the parameters to predict LN malignancy. The optimal cutoff values were calculated from each ROC curve and the diagnostic abilities were also compared. The diagnostic accuracies of the 3 methods were also assessed separately in smoking and nonsmoking patients.Twenty-eight LN stations were malignancy-positive and the remaining 142 were malignancy-negative. The AUCs for SUVindex, SUVn/t, and SUVmax were 0.709, 0.590, and 0.673, respectively, and the optimal cutoff values for SUVindex, SUVn/t, and SUVmax were 1.11, 0.34, and 3.6, respectively. The differences between SUVindex and SUVn/t were significant, but there was no significant difference between SUVindex and SUVmax. There were no significant differences between smokers and nonsmokers in the AUCs for any of the methods for predicting LN malignancy (P values >0.05).SUVindex may be a predictor of mediastinal LN malignancy in lung cancer patients.

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Combined Contrast-Enhanced Computed Tomography and 18-Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography in the Diagnosis and Staging of Non-small Cell Lung Cancer

Cited by 18 publications

References 33 publications

Ratio of Lymph Node to Primary Tumor SUV on PET/CT Accurately Predicts Nodal Malignancy in Non–Small-Cell Lung Cancer

Ratio of Lymph Node to Primary Tumor SUV on PET/CT Accurately Predicts Nodal Malignancy in Non–Small-Cell Lung Cancer

PET/CT in the Staging of the Non-Small-Cell Lung Cancer

Ratio of lymph node to primary tumor SUVmax multiplied by maximal tumor diameter on positron emission tomography/integrated computed tomography may be a predictor of mediastinal lymph node malignancy in lung cancer

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