Combined cytotoxic and genotoxic effects of ochratoxin A and fumonisin B1 in human kidney and liver cell models

Pinhão, Mariana; Tavares, Ana; Loureiro, Susana; Louro, Henriqueta; Alvito, Paula; Silva, Maria João

doi:10.1016/j.tiv.2020.104949

Cited by 24 publications

(7 citation statements)

References 55 publications

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“…The genotoxicity of FB 1 in in vitro testing is not clear. Following exposure to FB 1 no DNA damage was observed in human kidney and liver cells [ 131 ]. However, recent studies on human oesophageal epithelial cells suggest that this compound may promote carcinogenesis.…”

Section: Toxicologymentioning

confidence: 99%

Recent Research on Fusarium Mycotoxins in Maize—A Review

Bryła

Pierzgalski

Zapaśnik

et al. 2022

Foods

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Maize (Zea mays L.) is one of the most susceptible crops to pathogenic fungal infections, and in particular to the Fusarium species. Secondary metabolites of Fusarium spp.—mycotoxins are not only phytotoxic, but also harmful to humans and animals. They can cause acute or chronic diseases with various toxic effects. The European Union member states apply standards and legal regulations on the permissible levels of mycotoxins in food and feed. This review summarises the most recent knowledge on the occurrence of toxic secondary metabolites of Fusarium in maize, taking into account modified forms of mycotoxins, the progress in research related to the health effects of consuming food or feed contaminated with mycotoxins, and also the development of biological methods for limiting and/or eliminating the presence of the same in the food chain and in compound feed.

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Section: Toxicologymentioning

confidence: 99%

Recent Research on Fusarium Mycotoxins in Maize—A Review

Bryła

Pierzgalski

Zapaśnik

et al. 2022

Foods

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“…FB1 was shown to be involved in the development of renal carcinomas in male rats [12,17]. A synergistic pattern could also be observed with OTA and FB1 at low concentrations, shifting to antagonism at high concentration levels [18]. In addition to the focus on the kidney, synergistic effects between ZEN and DON exposure are observed in HepG2 cells [19].…”

Section: Introductionmentioning

confidence: 96%

Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort

et al. 2022

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Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox’s proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as µg/kg body weight/day. Results: Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development. Conclusions: These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addition, more occurrence data of, e.g., citrinin and fumonisins in different food commodities and countries in the EFSA database are a prerequisite to establish a greater degree of certainty.

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“…In the brain, FB1 was able to generate oxidative stress markers (Baldissera et al, 2020), neurochemistry toxicity (Gbore, 2010), facilitated seizures, as well as brain hyperexcitability (Poersh et al, 2015). Several studies reported also that FB1 induced immunotoxicity (Abbès et al, 2016), apoptosis (Zhang et al, 2018;Kim et al, 2018) and genotoxicity (Müller et al, 2012;Pinhão et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The ameliorative effect of Lactobacillus paracasei BEJ01 against FB1 induced spermatogenesis disturbance, testicular oxidative stress and histopathological damage

Ezdini

Salah-Abbès

Belgacem

et al. 2022

Toxicology Mechanisms and Methods

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Fumonisin B1 (FB1) was a possible carcinogenic molecule for humans as classi ed by the IARC on 2B group. In livestock, it was responsible for several mycotoxicosis and economic losses. Lactobacillus strains, inhabitants of a wide range of foodstuffs as well as our gastro-intestinal tract, were Generally Recognized as Safe (GRAS). Thus, the aim of this work was to evaluate the protective effect of Lactobacillus paracasei (LP) against FB1 induced reprotoxicities including testicular histopathology, sperm quality disturbance and testosterone level reduction.Pubescent mice were divided randomly into four groups as bellow: Group1: Control; Group 2: FB1 (100 µg/kg b.w); Group 3: LP (2× 10 9 CFU/kg b.w); Group 4: LP (2× 10 9 CFU/kg b.w) and FB1 (100 µg/kg b.w) to be then treated for 10 days.After the end of the treatment, animals were sacri ced; the plasma and epididyms and testicles were harvested to the reproductive system studies. Our results highlighted that LP counteracted the harmful effect generated by FB1. Indeed; it induced sperm quality reduction, oxidative stress generation and histological alterations.In conclusion, the used strain was able to prevent FB1-reproductive system damages of in balb/c mice and could be valorised as an anti-cating agent in animal FB1-contaminated diet.

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Combined cytotoxic and genotoxic effects of ochratoxin A and fumonisin B1 in human kidney and liver cell models

Cited by 24 publications

References 55 publications

Recent Research on Fusarium Mycotoxins in Maize—A Review

Recent Research on Fusarium Mycotoxins in Maize—A Review

Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort

The ameliorative effect of Lactobacillus paracasei BEJ01 against FB1 induced spermatogenesis disturbance, testicular oxidative stress and histopathological damage

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