2021
DOI: 10.3389/fimmu.2021.742154
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Combined Deficiency of the Melanocortin 5 Receptor and Adenosine 2A Receptor Unexpectedly Provides Resistance to Autoimmune Disease in a CD8+ T Cell-Dependent Manner

Abstract: Regulatory immunity that provides resistance to relapse emerges during resolution of experimental autoimmune uveitis (EAU). This post-EAU regulatory immunity requires a melanocortin 5 receptor (MC5r)-dependent suppressor antigen presenting cell (APC), as shown using a MC5r single knock-out mouse. The MC5r-dependent APC activates an adenosine 2A receptor (A2Ar)-dependent regulatory Treg cell, as shown using an A2Ar single knock-out mouse. Unexpectedly, when MC5r-/- post-EAU APC were used to activate A2Ar-/- pos… Show more

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Cited by 4 publications
(3 citation statements)
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“…In a study of the human gene, 5 variants were identified in a small sample of individuals with skin/sebaceous gland disorders, however, these same variants were also found with a similar distribution in individuals of a wide range of ethnicities who were phenotypically normal ( 23 ). In mouse models, there are also reports of roles for MC 5 in regulating immunological responses in autoimmune disorders of the eye, fatty acid oxidation in skeletal muscle, and lipolysis in adipocytes ( 24-28 ). To date there are no reported variants in the human gene associated with any of these roles.…”
Section: Established Physiological Roles Of Mcs and Consequences Of G...mentioning
confidence: 99%
“…In a study of the human gene, 5 variants were identified in a small sample of individuals with skin/sebaceous gland disorders, however, these same variants were also found with a similar distribution in individuals of a wide range of ethnicities who were phenotypically normal ( 23 ). In mouse models, there are also reports of roles for MC 5 in regulating immunological responses in autoimmune disorders of the eye, fatty acid oxidation in skeletal muscle, and lipolysis in adipocytes ( 24-28 ). To date there are no reported variants in the human gene associated with any of these roles.…”
Section: Established Physiological Roles Of Mcs and Consequences Of G...mentioning
confidence: 99%
“…MC5R in the perifornical lateral hypothalamus might mediate physical activity in lean rats [ 40 ]. In peripheral tissues, MC5R is involved in exocrine and endocrine gland secretion [ 41 , 42 ], defense behavior [ 43 , 44 ], thermoregulation [ 41 ], inflammation [ 45 , 46 ], and immune response [ 47 , 48 , 49 , 50 ]. MC5R regulates energy metabolism in the liver, adipose tissue, and skeletal muscle of various species, such as humans [ 51 , 52 , 53 , 54 ], mice [ 51 , 55 , 56 , 57 , 58 , 59 , 60 ], chickens [ 61 ], and sea bass [ 62 ].…”
Section: Introductionmentioning
confidence: 99%
“…In contrast to MC3R and MC4R, studies on MC5R are very limited [ 41 , 42 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 63 , 64 , 65 , 66 ]. Moreover, the role of MC5R in energy metabolism has been rarely investigated.…”
Section: Introductionmentioning
confidence: 99%