Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion

Bin, Kuang; Dai, Juan; Wang, Qingyu; Song, Rong; Jiao, Kai; Zhang, Jie; Tian, Xiaoguang; Duan, Yinzhong; Wang, Meiqing

doi:10.1016/j.ajodo.2012.08.024

Cited by 28 publications

(18 citation statements)

References 31 publications

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“…The increased mean RP to IP distance and occlusal interferences found for the DM1 group could be a result of the decreased muscle activity . Also degenerative changes in the TMJ may result in impaired occlusion, and skeletal jaw discrepancies and disordered occlusion have been associated with TMJ degenerative changes, but among the DM1 patients the TMJ changes were all mild, in accordance with another study , and had probably not influenced the occlusion and the bite opening.…”

Section: Discussionsupporting

confidence: 85%

Temporomandibular dysfunction in adult patients with myotonic dystrophy (DM1)

Mejersjö

Kiliaridis

2017

J of Oral Rehabilitation

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Myotonic muscle dystrophy is a systemic disease with early engagement of the facial muscles. Our aim was to study dysfunction of the temporomandibular system in patients with 'classic' dystrophia myotonica (DM1) and compare it with TMD patients and healthy controls. The study included 27 referred patients with DM1, 18 women and nine men, aged 30-62 years, and two matched control groups: patients with temporomandibular disorders symptoms (TMD) and healthy controls, both groups were consecutive patients. The patients answered questions regarding facial pain, jaw function and dysfunction. A clinical examination of the temporomandibular system including the occlusion was performed, and the maximum bite force and finger forces were measured. Among the DM1 patients, 33% reported difficulty biting off, and 22% had difficulty chewing, avoiding foods like meat and raw vegetables, and 37% of the DM1 patients scored their pain and discomfort as moderate to fairly severe. Their main complaints were TMJ clicking and locking, difficulty opening wide and tiredness. They had more clinical signs of dysfunction compared with the controls (P < 0·001), but no statistically significant difference to the TMD patients. The maximum bite force in DM1 patients was impaired compared to both the TMD patients and the controls (P < 0·001). Significantly more occlusal interferences were found in DM1 patients and were associated with chewing difficulties (P < 0·001). In conclusion, patients suffering from DM1 had an increased prevalence of TMD symptoms, reported impaired chewing function and had a decreased maximum bite force.

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Section: Discussionsupporting

confidence: 85%

Temporomandibular dysfunction in adult patients with myotonic dystrophy (DM1)

Mejersjö

Kiliaridis

2017

J of Oral Rehabilitation

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“…Although the aetiological mechanisms of OA remain unclear, studies suggest that the SDF-1/CXCR4 signaling pathway plays a vital role in its development[6,7,16,17]. In the knee, SDF-1 is produced by the synovium and secreted into the joint cavity and blood, however, its receptor CXCR4 is expressed on chondrocytes in the joint.…”

Section: Discussionmentioning

confidence: 99%

T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model

et al. 2017

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Osteoarthritis (OA) is one of the most common diseases affecting older people; however, there remains no effective targeted drug to combat OA. The aims of this study were (1) to explore the effect of T140 in regulating degeneration of articular cartilage in vivo by targeted blocking of the SDF-1/CXCR4 signaling pathway, and (2) to provide experimental evidence for the development of a novel OA-targeted pharmacotherapy. Thirty-six healthy Hartley guinea pigs were randomly divided into three groups: a T140-treated group (n = 12), a phosphate buffer saline control group (n = 12) and an untreated control group (n = 12). At 2, 4, 6, 8, 10 and 12 weeks of treatment, SDF-1 in serum was quantified by enzyme-linked immunosorbent assay. At 12 weeks of treatment, the cartilage from knee tibial plateau in the knee joint was collected for H&E, Safranin-O staining and Mankin grading; measurement for mRNA levels of matrix metalloproteinases (MMP-3, MMP-9 and MMP-13), aggrecan (ACAN) and collagen II (Col II) using RT-PCR; and measurement for Col II protein levels by western blot. Results showed that SDF-1 in serum increased in the T140 group and increased in the control groups. H&E and Safranin-O staining revealed less cartilage loss in T140-treated animals compared to controls. The mRNA levels of MMP-3, MMP-9 and MMP-13 in cartilage were much lower in the T140 group than other groups, but mRNA levels of ACAN and Col II in cartilage were higher in the T140-treated group. Col II protein levels in the T140 group and control groups were different. T140 can downregulate the expression of matrix-degrading enzyme and lessen the degeneration of cartilage by blocking the SDF-1/CRCR4 signaling pathway in vivo. This mechanism may present a pharmacological target for the treatment of OA.

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“…It has been reported that although the soft diet plays a negative role in condyle development 5,9,10 , rabbits or rats that received TMJ discectomy had less degenerative cartilage changes 43,44 and higher condylar cartilage sulfate uptake 45 when fed with soft diet. Besides catabolic changes, the chondrocytes in mechanically induced degraded articular cartilage displayed the reparative capability, including the activities of phagocytizing dead cells 46 and proliferation 26,33,36,37 . Hence, there might be a stronger repair response in TMJ cartilage in the small-size diet than the large-size diet group while the mice received the same kind of abnormal prosthesis.…”

Section: Discussionmentioning

confidence: 99%

Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis

Liu

Liao

Zhang

et al. 2014

Osteoarthritis and Cartilage

108

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Objective Dietary loading has been reported to have an effect on temporomandibular joint (TMJ) remodeling via periodontal-muscular reflex. We therefore examined whether reducing dietary loading decreased TMJ degradation induced by the unilateral anterior crossbite prosthesis as we recently reported. Methods Forty 6-week-old female C57BL/6J mice were randomly divided into two experimental and two control groups. One experimental and one control group received small-size diet and the other two groups received large-size diet. Unilateral anterior crossbite prosthesis was created in the two experimental groups. The TMJ samples were collected 3 weeks after experimental operation. Histological changes in condylar cartilage and subchondral bone were assessed by Hematoxylin & Eosin, toluidine blue, Safranin O and tartrate-resistant acid phosphatase staining. Real-time polymerase chain reaction (PCR) and/or immunohistochemistry were performed to evaluate the expression levels of Collagen II, Aggrecan, a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) and RANKL/RANK/OPG in TMJ condylar cartilage and/or subchondral bone. Results Thinner and degraded cartilage, reduced cartilage cellular density, decreased expression levels of Collagen II and Aggrecan, loss of subchondral bone and enhanced osteoclast activity were observed in TMJs of both experimental groups. However, the cartilage degradation phenotype was less severe and cartilage ADAMTS-5 mRNA was lower while OPG/RANKL ratio in cartilage and subchondral bone was higher in the small-size than large-size diet experimental group. No differences of histomorphology and the tested molecules were found between the two control groups. Conclusions The current findings suggest that a lower level of functional loading by providing small-size diet could reduce TMJ degradation induced by the biomechanical stimulation from abnormal occlusion.

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Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion

Cited by 28 publications

References 31 publications

Temporomandibular dysfunction in adult patients with myotonic dystrophy (DM1)

Temporomandibular dysfunction in adult patients with myotonic dystrophy (DM1)

T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model

Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis

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