Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma

Yang, Huilun; Hu, Haiyang; Gou, Yanling; Hu, Yu-hong; Li, Hui; Zhao, Hongwei; Wang, Beidi; Li, Peiling; Zhang, Zongfeng

doi:10.1007/s10147-017-1210-2

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…The multivariable logistic regression analysis showed that LVI, DI, TS, and SCC antigen level were independent risk factors, which is also consistent with previous reports ( 4 , 21 – 23 ). LVI is closely associated with LNM in CC.…”

Section: Discussionsupporting

confidence: 92%

“…In this study, the rate of LNM was 0.00% in patients with no LVI, a DI <1/2, and a TS <2 cm (low-risk group) according to the RPA. The negative LVI, less tumor size and less depth of invasion meant the less invasion in the intravascular system and parametrial involvement, leading to the less possibility of LNM ( 21 – 23 , 30 ). Lymphadenectomy may be avoided in these patients to reduce postoperative complications.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer

Xie

Cai

et al. 2022

Front. Oncol.

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ObjectivesTo assess the risk factors of lymph node metastasis (LNM) in patients with FIGO stage (2009) IB1 cervical cancer (CC).MethodsPatients with FIGO stage IB1 CC who underwent radical resection between 2012 and 2018 were recruited. The risk factors for LNM were analysed. A recursive partitioning analysis (RPA) was used to divide the patients into risk groups and assess their risk of LNM.ResultsThe 5-year overall survival rate was 91.72%, while 80.0% and 93.5% for patients with or without LNM (P<0.05). Multivariable logistic regression analysis showed that lymphovascular invasion (LVI), depth of invasion (DI), tumour size (TS), squamous cell carcinoma (SCC) antigen level were independent risk factors (all P<0.05). Patients were divided into low-risk (no LVI, DI <1/2, TS <2 cm), intermediate-risk (no LVI, DI <1/2, TS ≥2 cm; no LVI, DI ≥1/2, normal SCC level; LVI, DI <1/2, TS <2 cm), and high-risk (no LVI, DI ≥1/2, SCC level ≥1.5 ng/ml; LVI, TS <2 cm, DI ≥1/2; LVI, TS ≥2 cm) groups by RPA according to these four factors. The incidence of LNM among the three groups was 0.00%, 4.40%, and 24.10%, respectively (all P<0.001). The 5-year overall survival rates differed among the groups (98.2%, 92.7%, 83.0%, respectively, P=0.001).ConclusionsLNM affects the prognosis of patients with FIGO stage IB1 CC. Lymphadenectomy may be avoided for patients in the low-risk group and recommended for those in the high-risk group. Whether dissection is performed in the intermediate-risk group depends on the lymph node biopsy results.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer

Xie

Cai

et al. 2022

Front. Oncol.

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“…An elevated pretreatment SCC Ag level is associated with a more advanced stage [7–9], larger primary tumor size [7, 9, 10], regional nodal involvement [7, 8, 11, 12], and lymphovascular [8, 12] and deep stromal [8] infiltration in patients with cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

“…To avoid double-modality treatment, surgery should only be offered to patients with a low likelihood of undergoing adjuvant CCRT or radiotherapy. Pretreatment SCC Ag was associated with postoperative indications for adjuvant radiotherapy in patients with cervical cancer [8, 12, 20]. Reesink-Peters et al reported that in those with early-stage cervical cancer and elevated pretreatment SCC Ag levels (> 1.9 ng/ml), 57% of patients at FIGO stage IB1 and 74% of patients at FIGO stage IB2/IIA had postoperative indications for adjuvant radiotherapy; in contrast, among those with normal pretreatment SCC Ag levels, 16% of patients at FIGO stage IB1 and 29% of patients at FIGO stage IB2/IIA had indications.…”

Section: Introductionmentioning

confidence: 99%

The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer

Wang

et al. 2019

Radiat Oncol

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At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated with extensive tumors and poor survival for patients with cervical cancer treated with definitive CCRT. SCC Ag levels can be used to help physicians make decisions regarding surgery, avoiding the complications of double treatment modalities. Elevated SCC Ag is associated with radiotherapy resistance, and the rate of SCC Ag reduction during CCRT can predict tumor response after treatment. Moreover, the failure of SCC Ag levels to normalize posttreatment can predict tumor relapse, with a specificity higher than 70%, and adjuvant therapies should be considered for these patients. SCC Ag also plays an important role in the early detection of tumor relapse in patients with cervical cancer during follow-up after CCRT, with high sensitivity and good cost-effectiveness.

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“…Enhancement of cell migration and invasion capacity is associated with malignant progression and poor prognosis of CC [ 26 ]. To evaluate the effects of MAGI3 on migration and invasion of CC cells, MAGI3 was ectopically expressed in HeLa (HPV18 positive) and C‐33A (HPV18 negative) CC cells (Fig.…”

Section: Resultsmentioning

confidence: 99%

Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression

et al. 2021

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Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive. The carcinogenic properties of HPV18 require the PDZ-binding motif of its E6 oncoprotein (HPV18 E6) to degrade its target PSD95/Dlg/ZO-1 (PDZ) proteins. In this study, we demonstrated that the PDZ protein membrane-associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) inhibited the Wnt/b-catenin pathway, and subsequently cervical cancer (CC) cell migration and invasion, via decreasing b-catenin levels. By reducing MAGI3 protein levels, HPV18 E6 promoted CC cell migration and invasion through activation of Wnt/bcatenin signaling. Furthermore, HPV18 rather than HPV16 was preferentially associated with the downregulation of MAGI3 and activation of the Wnt/b-catenin pathway in CC. These findings shed light on the mechanism that gives HPV18 its high carcinogenic potential in CC progression.Cervical cancer (CC) is the fourth most prominent type of cancer in women [1]. Infection with high-risk types of human papillomaviruses (HR-HPVs) is the main cause for the transformation of normal cervical epithelium to cervical intraepithelial neoplasia (CIN) and progression to invasive cervical cancer (ICC) [2,3]. The 5-year overall survival for early-stage patients (stage I) of CC reaches 88%, and this percentage Abbreviations CC, cervical cancer; CIN, cervical intraepithelial neoplasia; CIS, carcinoma in situ; FDR, false discovery rate; GSEA, gene set enrichment analysis; HG-CIN, high-grade cervical intraepithelial neoplasia; HPV16, human papillomavirus type 16; HPV18, human papillomavirus type 18; HR-HPVs, high-risk types of human papillomaviruses; ICC, invasive cervical cancer; IHC, immunohistochemistry; MAGI3, membraneassociated guanylate kinase, WW and PDZ domain containing 3; NHERF1, Na + /H + exchanger regulatory factor 1; PBM, PDZ-binding motif; PDZ, PSD95/Dlg/ZO-1; TCGA, The Cancer Genome Atlas.

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Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma

Abstract: Combined detection of Twist1 and Snail1 in SCCA-positive biopsy specimens may be a potential method for evaluating the invasion and metastasis of CSCC prior to surgery.

Cited by 14 publications

References 31 publications

Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer

Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer

The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer

Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression

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