Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets

Lépine, Alexia F P; Konstanti, Prokopis; Borewicz, Klaudyna; Resink, J.W.; Wit, Nicole J. de; Vos, Paul de; Smidt, Hauke; Mes, Jurriaan J.

doi:10.1038/s41598-019-54353-1

Cited by 15 publications

(5 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…plantarum could reduce inflammatory markers such as IFN-α, IFN-β, and IL-6 and block virus replication by interaction with SARS-CoV-2 helicase ( 104 ). L. acidophilus W37 (LaW37) with long-chain inulin (lcITF) was also used as a probiotic in a study on piglets and increased two-folded vaccine efficacy against Salmonella Typhimurium strains (STM) ( 105 ).…”

Section: The Effects Of Probiotics On Vaccine Efficacymentioning

confidence: 99%

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

2022

View full text Add to dashboard Cite

Vaccination is defined as the stimulation and development of the adaptive immune system by administering specific antigens. Vaccines' efficacy, in inducing immunity, varies in different societies due to economic, social, and biological conditions. One of the influential biological factors is gut microbiota. Cross-talks between gut bacteria and the host immune system are initiated at birth during microbial colonization and directly control the immune responses and protection against pathogen colonization. Imbalances in the gut microbiota composition, termed dysbiosis, can trigger several immune disorders through the activity of the adaptive immune system and impair the adequate response to the vaccination. The bacteria used in probiotics are often members of the gut microbiota, which have health benefits for the host. Probiotics are generally consumed as a component of fermented foods, affect both innate and acquired immune systems, and decrease infections. This review aimed to discuss the gut microbiota's role in regulating immune responses to vaccination and how probiotics can help induce immune responses against pathogens. Finally, probiotic-based oral vaccines and their efficacy have been discussed.

show abstract

Section: The Effects Of Probiotics On Vaccine Efficacymentioning

confidence: 99%

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

2022

View full text Add to dashboard Cite

show abstract

“…A similar study showed increase Salmonella translocation with FOS and lactulose in rats (Bovee-Oudenhoven, 2003;Ten Bruggencate et al, 2003). A more recent study showed improved effects of fructo-oligosaccharides on piglet health against Salmonella infection (Lepine et al, 2019). In a guinea pig model for Listeria infection, other prebiotics had a similar effect (Ebersbach et al, 2010).…”

Section: Effects On Gut Infectionsmentioning

confidence: 83%

Structure and function of non-digestible carbohydrates in the gut microbiome

Rastall

Díez-Municio

Forssten³

et al. 2022

View full text Add to dashboard Cite

Together with proteins and fats, carbohydrates are one of the macronutrients in the human diet. Digestible carbohydrates, such as starch, starch-based products, sucrose, lactose, glucose and some sugar alcohols and unusual (and fairly rare) α-linked glucans, directly provide us with energy while other carbohydrates including high molecular weight polysaccharides, mainly from plant cell walls, provide us with dietary fibre. Carbohydrates which are efficiently digested in the small intestine are not available in appreciable quantities to act as substrates for gut bacteria. Some oligo- and polysaccharides, many of which are also dietary fibres, are resistant to digestion in the small intestines and enter the colon where they provide substrates for the complex bacterial ecosystem that resides there. This review will focus on these non-digestible carbohydrates (NDC) and examine their impact on the gut microbiota and their physiological impact. Of particular focus will be the potential of non-digestible carbohydrates to act as prebiotics, but the review will also evaluate direct effects of NDC on human cells and systems.

show abstract

“…The revised definition instead focused on the concept of ecological and functional characteristics of the microbiota to be relevant for host physiology, such as ecosystem diversity, and the support of broad microbial consortia. Many studies focusing on prebiotics such as inulin, fructooligosaccharides, galactooligosaccharides, and mannanoligosaccharides, proved the link between prebiotics consumption and restoring intestinal balance (184)(185)(186)(187). Additionally, regardless of bacterial fermentation, prebiotic oligosaccharides (such as fructooligosaccharides and galactooligosaccharides) were shown to exert an anti-inflammatory effect or have an anti-adhesive activity to inhibit binding pathogens (188,189).…”

Section: Prebioticsmentioning

confidence: 99%

Intestinal Health of Pigs Upon Weaning: Challenges and Nutritional Intervention

et al. 2021

View full text Add to dashboard Cite

The primary goal of nursery pig management is making a smooth weaning transition to minimize weaning associated depressed growth and diseases. Weaning causes morphological and functional changes of the small intestine of pigs, where most of the nutrients are being digested and absorbed. While various stressors induce post-weaning growth depression, the abrupt change from milk to solid feed is one of the most apparent challenges to pigs. Feeding functional feed additives may be viable solutions to promote the growth of nursery pigs by enhancing nutrient digestion, intestinal morphology, immune status, and by restoring intestinal balance. The aim of this review was to provide available scientific information on the roles of functional feed additives in enhancing intestinal health and growth during nursery phase. Among many potential functional feed additives, the palatability of the ingredient and the optimum supplemental level are varied, and these should be considered when applying into nursery pig diets. Considering different stressors pigs deal with in the post-weaning period, research on nutritional intervention using a single feed additive or a combination of different additives that can enhance feed intake, increase weight gain, and reduce mortality and morbidity are needed to provide viable solutions for pig producers. Further research in relation to the feed palatability, supplemental level, as well as interactions between different ingredients are needed.

show abstract

Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets

Cited by 15 publications

References 78 publications

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy

Structure and function of non-digestible carbohydrates in the gut microbiome

Intestinal Health of Pigs Upon Weaning: Challenges and Nutritional Intervention

Contact Info

Product

Resources

About