Combined Diffusion Imaging and MR Spectroscopy in the Diagnosis of Human Prion Diseases

Galanaud, Damien; Haı̈k, Stéphane; Linguraru, Marius George; Ranjeva, Jean‐Philippe; Faucheux, Baptiste; Kaphan, Elsa; Ayache, Nicholas; Chiras, J.; Cozzone, Patrick J.; Dormont, Didier; Brandel, Jean‐Philippe

doi:10.3174/ajnr.a2069

Cited by 39 publications

(42 citation statements)

References 36 publications

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“…Other reports have suggested that PrP Sc plaque deposition might be responsible for the decreased water diffusivity (11,20). One recent MR spectroscopy study used metabolites as surrogate markers of histological changes further supported a role of prion protein deposition in the production of diffusion restriction (11). Neuronal stress, which results in neuropil vacuolization, should theoretically decrease the N-acetyl-aspartate (NAA) levels whereas astrocytosis should increase myoinositol.…”

Section: Neuroimagingmentioning

confidence: 99%

“…MRI is far more sensitive, especially with the addition of FLAIR and diffusionweighted imaging (DWI). DWI is the most useful sequence with reported sensitivity ranging from 86 to 94% (8)(9)(10)(11). DWI also benefit from greater inter-observer agreement compared with FLAIR or T2 (8).…”

Section: Neuroimagingmentioning

confidence: 99%

“…Indeed, DWI findings may become less conspicuous in the terminal stage of the disease and may even normalize (8,(16)(17)(18). This evolution may be related to increased gliosis, producing increased water diffusivity, thus balancing the restricted diffusion seen earlier in the disease (11,19). Other reports have suggested that PrP Sc plaque deposition might be responsible for the decreased water diffusivity (11,20).…”

Section: Neuroimagingmentioning

confidence: 99%

“…This evolution may be related to increased gliosis, producing increased water diffusivity, thus balancing the restricted diffusion seen earlier in the disease (11,19). Other reports have suggested that PrP Sc plaque deposition might be responsible for the decreased water diffusivity (11,20). One recent MR spectroscopy study used metabolites as surrogate markers of histological changes further supported a role of prion protein deposition in the production of diffusion restriction (11).…”

Section: Neuroimagingmentioning

confidence: 99%

“…However, with the widespread adoption of FLAIR and DWI, numerous studies have demonstrated the added value of MRI in the diagnosis of CJD. Reported sensitivity values for MRI are between 83 and 100% (9,10,31,40), reaching 92-94% in prospective studies using DWI (8,11). Although the reported sensitivity of MRI is high, it is important to highlight the possibility of falsely negative MRI.…”

Section: Sporadic Creutzfeldt-jakob Diseasementioning

confidence: 99%

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Imaging of prion diseases

Létourneau-Guillon

Wada²,

Kucharczyk

2012

Magnetic Resonance Imaging

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Prion diseases are caused by self‐replicating proteins that induce lethal neurodegenerative disorders. In the last decade, the understanding of the different clinical, pathological, and neuroimaging phenotypes of this group of disorders has evolved paralleling the advances in prion molecular biology. From an imaging standpoint, the implementation of diffusion‐weighted imaging in routine practice has markedly facilitated the detection of prion diseases, especially Creutzfeldt‐Jakob. Less frequent prion‐related disorders, including genetic diseases, may also benefit from progresses in the field of quantitative diffusion‐weighted imaging, MR spectroscopy or molecular imaging. Herein, we present a review of the neuroimaging features of the prion disorders known to affect humans emphasizing the important contribution of MRI in the diagnosis of this group of disorders. J. Magn. Reson. Imaging 2012;35:998‐1012. © 2012 Wiley Periodicals, Inc.

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Section: Neuroimagingmentioning

confidence: 99%

Section: Neuroimagingmentioning

confidence: 99%

Section: Neuroimagingmentioning

confidence: 99%

Section: Neuroimagingmentioning

confidence: 99%

Section: Sporadic Creutzfeldt-jakob Diseasementioning

confidence: 99%

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Imaging of prion diseases

Létourneau-Guillon

Wada²,

Kucharczyk

2012

Magnetic Resonance Imaging

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Capillary electromigration based techniques in diagnostics of prion protein caused diseases

et al. 2012

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Transmissible spongiform encephalopathies are a group of fatal neurodegenerative diseases with long incubation time. This group includes Creutzfeld-Jakob disease, kuru, scrapie, chronic wasting disease, and bovine spongiform encephalopathy. Sensitive and specific detection of abnormal prion protein as "a source agent" of the above-mentioned diseases in blood could provide a diagnostic test or a screening assay for animal and human prion protein diseases diagnostics. Therefore, diagnostic tests for prion protein diseases represent unique challenge requiring development of novel assays exploiting properties of prion protein complex. Presently, diagnostic methods such as protein misfolding cyclic amplification, conformation-dependent immunoassay, dissociation-enhanced lanthanide fluorescent immunoassay, fluorescence correlation spectroscopy, and/or flow microbead immunoassay are used for abnormal prion protein (PrP(Sc) ) detection. On the other hand, using of CE for PrP(Sc) detection in body fluids is an attractive alternative; it has been already applied for the blood samples of infected sheep, elk, chimpanzee, as well as humans. In this review, assays for prion protein detection are summarized with special attention to capillary electromigration based techniques, such as CE, CIEF, and/or CGE. The potential of the miniaturized and integrated lab-on-chip devices is highlighted, emphasizing recent advances of this field in the proteomic analysis.

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MR Spectroscopy in Health and Disease

Öz

2021

Handbook of the Cerebellum and Cerebellar Disorders

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Magnetic resonance spectroscopy (MRS) enables the noninvasive quantification of up to 20 neurochemicals in selected brain regions and has found many applications in the study of the cerebellum in health and disease. The neurochemicals accessible by MRS include neuronal and glial markers, neurotransmitters, markers of cellular energetics, and antioxidants and, therefore, provide means to assess neuronal dysfunction/loss, glial activation, energy metabolism, and oxidative stress. As a result, the methodology has been applied to the study of many diseases that affect the cerebellum, including neurodegenerative diseases, cancer, metabolic disorders, alcoholism, and neuropsychiatric disorders. While MRS of the cerebellum poses challenges due to the caudal location of the structure in the brain, these have been overcome both on research and clinical scanners that operate at high and ultra-high magnetic fields, providing the potential for further

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Combined Diffusion Imaging and MR Spectroscopy in the Diagnosis of Human Prion Diseases

Cited by 39 publications

References 36 publications

Imaging of prion diseases

Imaging of prion diseases

Capillary electromigration based techniques in diagnostics of prion protein caused diseases

MR Spectroscopy in Health and Disease

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