Combined Doppler ultrasound and platelet indices for prediction of preeclampsia in high-risk pregnancies

Razik, Mohamed Abdel; Mostafa, Asmaa; Taha, Sara; Salah, Ahmed

doi:10.1080/14767058.2018.1481953

Cited by 12 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data analysis in this study indicated that abnormal uterine Doppler indices and the presence of a notch between the 19th and 22nd weeks of gestation in normal singleton pregnancies is a risk factor of developing adverse maternal and fetal outcomes such as fetal growth restriction, SGA, severe preeclampsia, HELLP, oligohydramnios placental insufficiency and placental abruption. These findings are compatible with previous studies of uterine arteries Doppler screening and the combined screening including maternal characteristics and history (3,5,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Although the identification of high-risk pregnancies in the second trimester could not yet improve maternal and fetal morbidity and mortality as demonstrated in several studies in the past 20 years, the administration of a daily low dose of aspirin starting before the 16th week of gestation has shown significant reduction in the prevalence of these complications (3,11,(22)(23)(24)(25).…”

Section: Discussionsupporting

confidence: 90%

Doppler Indices and Notching Assessment of Uterine Artery Between the 19th and 22nd Week of Pregnancy in the Prediction of Pregnancy Outcome

Ratiu

Hide-Moser

Morgenstern

et al. 2019

In Vivo

View full text Add to dashboard Cite

Background/Aim: The aim of this study was to determine the value of Doppler indices and notching assessment of uterine artery between the 19th and 22nd week of gestation in the prediction of pregnancy outcome such as delivery mode, birth weight, Apgar score, afterbirth pH, fetal presentation, preeclampsia and fetal growth restriction in singleton pregnancy. Patients and Methods: This is a retrospective cohort study of Doppler ultrasound of the uterine arteries at 19-22 week of gestation in 1,472 women with singleton pregnancies. Results: Patients with bilateral high resistance-index (RI) and pulsatility-index (RI) or with the presence of a notch showed a significantly higher prevalence of small for gestational age (SGA) fetuses and intrauterine growth restriction (IUGR), low Apgar Scores at the 1st and the 5th min, high c-section rate, preterm birth, breech birth, placental insufficiency and placental abruption. The presence of a notch significantly increased the prevalence of severe preeclampsia, HELLP-syndrome and oligohydramnios. Also, patients with a bilateral uterine notching had a higher c-section rate along with higher prevalence of SGA and IUGR at screening time. Conclusion: Uterine artery Doppler waveform analysis as well as the assessment of the presence of a notch in the second trimester can be used as a screening method to identify women who will thereafter develop a severe adverse outcome.

show abstract

Section: Discussionsupporting

confidence: 90%

Doppler Indices and Notching Assessment of Uterine Artery Between the 19th and 22nd Week of Pregnancy in the Prediction of Pregnancy Outcome

Ratiu

Hide-Moser

Morgenstern

et al. 2019

In Vivo

View full text Add to dashboard Cite

show abstract

“…Doppler was used to report the accumulation of platelets radiolabelled with 111‐indium in atherogenic arteries in patients with cerebral ischemia 25 . Abnormal platelet index combined with high pulsatility index and resistance index values in Doppler analysis results in a higher incidence of severe preeclampsia 26 . Thus, the platelets may interact with the endothelium leading to endothelial dysfunction; however, the mechanisms involved in this interaction are unknown.…”

Section: Endothelial Dysfunction In Gdmmentioning

confidence: 99%

Platelets and endothelial dysfunction in gestational diabetes mellitus

et al. 2023

View full text Add to dashboard Cite

The prevalence of gestational diabetes mellitus (GDM) has increased in recent years, along with the higher prevalence of obesity in women of reproductive age.GDM is a pathology associated with vascular dysfunction in the fetoplacental unit. GDM-associated endothelial dysfunction alters the transfer of nutrients to the foetus affecting newborns and pregnant women. Various mechanisms for this vascular dysfunction have been proposed, of which the most studied are metabolic alterations of the vascular endothelium. However, different cell types are involved in GDM-associated endothelial dysfunction, including platelets. Platelets are small, enucleated cell fragments that actively take part in blood haemostasis and thrombus formation. Thus, they play crucial roles in pathologies coursing with endothelial dysfunction, such as atherosclerosis, cardiovascular diseases, and diabetes mellitus. Nevertheless, platelet function in GDM is understudied.Several reports show a potential relationship between platelet volume and mass with GDM; however, platelet roles and signaling mechanisms in GDM-associated endothelial dysfunction are unclear. This review summarizes the reported findings and proposes a link among altered amount, volume, mass, reactivity, and

show abstract

“…These authors confirmed conclusion of previously mentioned study, and showed that analysis of maternal factors, uterine artery PI by Doppler, mean arterial pressure and serum placental growth factor (PLGF) enabled prediction over 90% of preeclampsia. Abdel Razik and colleagues investigated the interconnection between Doppler ultrasound parameters: diastolic notch, PI and RI, and platelet indices: platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (Plcr) (24). They analyzed 270 normal pregnant women between 20 th and 24 th week of gestation and showed that patients with preeclampsia had higher frequency of diastolic notching, as well as higher PI and RI, combined with significant increase of MPV and PDW.…”

Section: Uterine Artery Doppler In Preeclampsia Predictionmentioning

confidence: 99%

Preeclampsia – Prediction and Monitoring Factors

Rudic

Raičević

Babić

2019

Serbian Journal of Experimental and Clinical Research

View full text Add to dashboard Cite

Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality, usually characterized by hypertension and proteinuria. Despite high incidence of preeclampsia the pathophysiological basis of preeclampsia is still not clear and there are a number of mechanisms and signaling pathways that intertwine. It is very important to develop specific and reliable predictive algorithms in order to enable early initiation of therapy due to facts that incidence of preeclampsia has upward trend and that cause adverse maternal and fetal outcome. Some of the most commonly used methods for prediction of preeclampsia include uterine artery Doppler velocimetry, determination of some microRNA, such as miR-210, and assessment of various pro-angiogenic and anti-angiogenic factors from blood. Angiogenic factors that possibly have most important role in pathogenesis of preeclampsia are vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), which promote angiogenesis, and soluble fms-like tyrosine kinase-1 (sFlt1) and soluble form of endoglin (s-Eng), which exhibit anti-angiogenic properties. Aggravating circumstance is that preeclampsia has heterogeneous origin, and due to this fact, the value of individual markers can vary significantly. There is a constant tendency for creating comprehensive algorithm for prediction of preeclampsia which would be sufficiently specific and sensitive, and in the same time cheap and available. In that sense, new clinical studies are needed to show the most effective combination of parameters in the predeclampsia prediction.

show abstract

Combined Doppler ultrasound and platelet indices for prediction of preeclampsia in high-risk pregnancies

Abstract: Abnormal platelet indices combined with abnormal Doppler is a predictor of severity rather than the rate of development of PE.

Cited by 12 publications

References 20 publications

Doppler Indices and Notching Assessment of Uterine Artery Between the 19th and 22nd Week of Pregnancy in the Prediction of Pregnancy Outcome

Doppler Indices and Notching Assessment of Uterine Artery Between the 19th and 22nd Week of Pregnancy in the Prediction of Pregnancy Outcome

Platelets and endothelial dysfunction in gestational diabetes mellitus

Preeclampsia – Prediction and Monitoring Factors

Contact Info

Product

Resources

About