Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population

Bobeuf, Florian; Labonté, Mélissa; Dionne, Isabelle J.; Khalil, Abdelouahed

doi:10.1007/s12603-011-0097-2

Cited by 60 publications

(66 citation statements)

References 57 publications

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“…Other studies have not found an effect of resistance training on other markers of free-radical damage. For example, a study by Bobeuf et al [144] did not detect any differences in plasma MDA and urinary F 2 -isoprostane levels between before and after resistance training in older adults. The differences in these studies' results may be related to the choice of markers of free-radical damage, as well as the measuring compartments (blood, muscle, plasma).…”

Section: Oxidative Stress and Resistance Training In Elderly Peoplementioning

confidence: 92%

Radical Oxygen Species, Exercise and Aging: An Update

et al. 2015

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It is now well established that reactive oxygen species (ROS) play a dual role as both deleterious and beneficial species. In fact, ROS act as secondary messengers in intracellular signalling cascades; however, they can also induce cellular senescence and apoptosis. Aging is an intricate phenomenon characterized by a progressive decline in physiological functions and an increase in mortality, which is often accompanied by many pathological diseases. ROS are involved in age-associated damage to macromolecules, and this may cause derangement in ROS-mediated cell signalling, resulting in stress and diseases. Moreover, the role of oxidative stress in age-related sarcopenia provides strong evidence for the important contribution of physical activity to limit this process. Regular physical activity is considered a preventive measure against oxidative stress-related diseases. The aim of this review is to summarize the currently available studies investigating the effects of chronic and/or acute physical exercise on the oxidative stress process in healthy elderly subjects. Although studies on oxidative stress and physical activity are limited, the available information shows that acute exercise increases ROS production and oxidative stress damage in older adults, whereas chronic exercise could protect elderly subjects from oxidative stress damage and reinforce their antioxidant defences. The available studies reveal that to promote beneficial effects of physical activity on oxidative stress, elderly subjects require moderate-intensity training rather than high-intensity exercise.

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Section: Oxidative Stress and Resistance Training In Elderly Peoplementioning

confidence: 92%

Radical Oxygen Species, Exercise and Aging: An Update

et al. 2015

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“…Only three human training studies have applied a high-force, resistance mode of exercise; i.e., traditional strength training [23,24] and eccentric exercise [25]. In a study by Theodorou et al [25], no effects of vitamin C and E supplementation (1000 mg and 400 IU, respectively) were found on either recovery after eccentric exercise or adaptation to 4 weeks of eccentric training.…”

Section: Introductionmentioning

confidence: 99%

Can supplementation with vitamin C and E alter physiological adaptations to strength training?

Paulsen

Cumming

Hamarsland

et al. 2014

BMC Sports Sci Med Rehabil

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BackgroundAntioxidant supplementation has recently been demonstrated to be a double-edged sword, because small to moderate doses of exogenous antioxidants are essential or beneficial, while high doses may have adverse effects. The adverse effects can be manifested in attenuated effects of exercise and training, as the antioxidants may shut down some redox-sensitive signaling in the exercised muscle fibers. However, conditions such as age may potentially modulate the need for antioxidant intake. Therefore, this paper describes experiments for testing the hypothesis that high dosages of vitamin C (1000 mg/day) and E (235 mg/day) have negative effects on adaptation to resistance exercise and training in young volunteers, but positive effects in older men.Methods/designWe recruited a total of 73 volunteers. The participants were randomly assigned to receiving either vitamin C and E supplementation or a placebo. The study design was double-blinded, and the participants followed an intensive training program for 10–12 weeks. Tests and measurements aimed at assessing changes in physical performance (maximal strength) and physiological characteristics (muscle mass), as well as biochemical and cellular systems and structures (e.g., cell signaling and morphology).DiscussionDietary supplements, such as vitamin C and E, are used by many people, especially athletes. The users often believe that high dosages of supplements improve health (resistance to illness and disease) and physical performance. These assumptions are, however, generally not supported in the scientific literature. On the contrary, some studies have indicated that high dosages of antioxidant supplements have negative effects on exercise-induced adaptation processes. Since this issue concerns many people and few randomized controlled trials have been conducted in humans, further studies are highly warranted.Trial registrationACTRN12614000065695

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“…Anti-oxidant supplementation was not associated with any improvements in blood markers of recovery, perceived muscle soreness, or muscle function. Similarly, no difference in strength gains with vitamin C and E supplementation compared to placebo occurred after 6 months of resistance training in older adults [18]. Antioxidant supplementation may blunt the endogenous adaptive responses to exercise-induced oxidative stress such as improvements in insulin sensitivity [20].…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidant supplementation may blunt the endogenous adaptive responses to exercise-induced oxidative stress such as improvements in insulin sensitivity [20]. The consequences of these effects remain unclear, yet the limited data demonstrate no ergogenic benefit associated with antioxidant supplementation during resistance training [17,18]. …”

Section: Discussionmentioning

confidence: 99%

Effect of an herbal/botanical supplement on strength, balance, and muscle function following 12-weeks of resistance training: a placebo controlled study

Furlong

Rynders

Sutherlin

et al. 2014

Journal of the International Society of Sports Nutrition

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BackgroundStemSport (SS; StemTech International, Inc. San Clemente, CA) contains a proprietary blend of the botanical Aphanizomenon flos-aquae and several herbal antioxidant and anti-inflammatory substances. SS has been purported to accelerate tissue repair and restore muscle function following resistance exercise. Here, we examine the effects of SS supplementation on strength adaptations resulting from a 12-week resistance training program in healthy young adults.MethodsTwenty-four young adults (16 males, 8 females, mean age = 20.5 ± 1.9 years, mass = 70.9 ± 11.9 kg, stature = 176.6 ± 9.9 cm) completed the twelve week training program. The study design was a double-blind, placebo controlled parallel group trial. Subjects either received placebo or StemSport supplement (SS; mg/day) during the training. 1-RM bench press, 1-RM leg press, vertical jump height, balance (star excursion and center of mass excursion), isokinetic strength (elbow and knee flexion/extension) and perception of recovery were measured at baseline and following the 12-week training intervention.ResultsResistance training increased 1-RM strength (p < 0.008), vertical jump height (p < 0.03), and isokinetic strength (p < 0.05) in both SS and placebo groups. No significant group-by-time interactions were observed (all p-values >0.10).ConclusionsThese data suggest that compared to placebo, the SS herbal/botanical supplement did not enhance training induced adaptations to strength, balance, and muscle function above strength training alone.

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Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population

Cited by 60 publications

References 57 publications

Radical Oxygen Species, Exercise and Aging: An Update

Radical Oxygen Species, Exercise and Aging: An Update

Can supplementation with vitamin C and E alter physiological adaptations to strength training?

Effect of an herbal/botanical supplement on strength, balance, and muscle function following 12-weeks of resistance training: a placebo controlled study

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