Combined effect of fascioliasis and diethylnitrosamine carcinogenesis on the activity of the rat liver monooxygenase system

Tsocheva, N.; Kadiiska, Maria B.; Poljakova-Krusteva, O.; Krustev, L; Yanev, S; Stoytchev, Tsanko S.

doi:10.1016/0742-8413(92)90073-g

Cited by 7 publications

(10 citation statements)

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“…m/z 571) and as well as DNA-adducts (m/z 599) [4]. This was expected since these parasites all reside within the bile ducts and fascioliasis can induce DNA damage [10,17]. To reiterate, however, these were fewer of these compounds in F. hepatica compared to Opisthorchis spp.…”

Section: Resultsmentioning

confidence: 99%

“…tumor growth stimulation and inhibition. Tumor growth stimulation and proliferation of hepatocytes has been observed during acute phase of infection where larval flukes migrate through the parenchyma of the liver and provoke marked inflammation [12,17]. In turn, the chronic inflammation increases oxidative stress that can overwhelm antioxidant system homeostasis to dampen reactive oxygen species and consequent oxidative modification of lipids, nucleic acids and proteins [9].…”

Section: Discussionmentioning

confidence: 99%

“…Whereas acute F. hepatica infection may increase the metabolizing enzymes in liver and thus increase the activation of exogenous carcinogens [22], chronic infection may reduce hepatic metabolizing activity [12]. It is noteworthy that chronic infection with F. hepatica in a rat model suppressed N -nitrosodimethyldiamine-induced carcinogenesis, suggesting a parasite-induced inhibition of carcinogenesis in the liver of rodents experimentally infected with F. hepatica [17]. All these hypotheses require further investigation and experimental validation.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Fasciola hepatica has a wide geographical range, causes major economic loss in sheep and cattle worldwide, and also is an important food borne trematodes (FBT) pathogen of humans [16]. Fascioliasis can induce host DNA damage through action of reactive nitric species (RNS) or oxygen species (ROS) [15,17]. We hypothesized that the first step for carcinogenesis associated with the chronic infection with S. haematobium and O. viverrini involved the ability of parasite metabolites to directly promote DNA lesions [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Gouveia

Pakharukova

Sripa

et al. 2019

Preprint

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50 Chronic infections with the flatworm parasites Opisthorchis viverrini, Clonorchis sinensis and 51 Schistosoma haematobium are classified as group 1 biological carcinogens, i.e. definitive causes 52 of cancer. In addition, we reported findings that support the inclusion of Opisthorchis felineus in 53 this list of biological carcinogens. By contrast, infections with close phylogenetic relatives 54 including Fasciola hepatica have not been associated with carcinogenesis. Earlier reports revealed 55 of oxysterol metabolites of Opisthorchis liver fluke origin conjugated with DNA bases, suggesting 56 that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of 57 the infection with these food-borne pathogens. Here we employed liquid chromatography-mass 58 spectrometry (LC-MS/MS) to investigate, compare and contrast spectrograms of soluble extracts 59 from F. hepatica adult worms from bile ducts of cattle with those from O. viverrini and O. felineus 60 from experimentally-infected hamsters. F. hepatica displayed a complex spectrophotometric 61 profile. F. hepatica and Opisthorchis spp. shared several common compounds including oxysterol-62 like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of these Opisthorchis 63 species included far fewer compounds than F. hepatica. These findings support the postulate that 64 oxysterol-like metabolites of parasite origin can initiate carcinogenesis and they point to a 65 molecular basis for the inconsistencies among major groups of liver flukes concerning infection-66 induced malignancy. 67 (202 words) 68 69 70 71 72 73 4 74 Author Summary 75 Several species of trematodes are parasites of the human hepatobiliary tract. Infection with 76 two of these flukes, Clonorchis sinsensis and Opisthorchis viverrini, fresh water fish-borne 77 parasites that occur in East Asia is classified as group 1 carcinogens by the International Agency 78 for Research on Cancer (IARC), i.e. definitive causes of cancer in humans. By contrast, infection 79 with a different liver fluke, Fasciola hepatica, does not lead to malignant transformation of the 80 biliary tract. Given the close phylogeny of all three parasites, this difference in carcinogenicity is 81 intriguing and, if explained, likely of value in novel therapeutic approaches. The importance of the 82 current findings is informative because they present a mass spectrometric analysis and catalog of 83 the similarities and differences between fluke of the genus Opisthorchis and F. hepatica, 84 potentially identifying carcinogenic metabolites of liver fluke origin. These metabolites can be 85 expected to provide deeper understanding of helminth infection induced malignancy. 86 (149 words) 87 88 89 90 91 92 Keywords 93 Fasciola hepatica, Opisthorchis viverrini; Opisthorchis felineus; oxysterols; DNA adducts 94 95 5 96 97 More than 20% of cancer in the developing world are caused by infections [1]. The World 98 Health Organization's International Agency for Research on Cancer (IARC) recognizes ...

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Gouveia

Pakharukova

Sripa

et al. 2019

Preprint

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“…For instance, Fasciola hepatica has a wide geographical range, causes major economic loss in sheep and cattle worldwide, and also is an important zoonosis in humans (Villegas et al, 2012). It has been shown that fascioliasis can induce host DNA damage through action of reactive nitric species (RNS) or oxygen species (ROS) (Mayer & Fried, 2007;Tsocheva et al, 1992); however, the infection has not been associated to carcinogenesis. Seeking new insights in this apparent paradox among closely related foodborne trematodes, here we conducted an analysis of soluble extracts of adult worms of F. hepatica, O. viverrini and O. felineus by liquid chromatography coupled with mass spectrometry (LC-MS/MS).…”

Section: Introductionmentioning

confidence: 99%

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

et al. 2020

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Earlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy.

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The Role of Helminthes and Fungi in Cancer Development

Kutikhin

Yuzhalin

Брусина

2012

Infectious Agents and Cancer

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Combined effect of fascioliasis and diethylnitrosamine carcinogenesis on the activity of the rat liver monooxygenase system

Cited by 7 publications

References 8 publications

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

The Role of Helminthes and Fungi in Cancer Development

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