Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery

Torrego-Ellacuría, Macarena; Barabash, Ana; Matía, Pilar; Sánchez‐Pernaute, Andrés; Torres, Antonio; Calle-Pascual, Alfonso; Rubio, Miguel A.

doi:10.3390/jcm12134288

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Other authors confirm that carriers of a heterozygous variant in the leptin-melanocortin pathway have a progressive and significant weight regain in the mid- and long-term after RYGB [ 226 ]. Studies that combine several SNPs suggest that weight loss and long term weight regain after bariatric surgery may be influenced by multiple genetic variants [ 227 ]. A combination of several genes and the development of a genetic risk score may have a predictive value for an individual’s predisposition to obesity [ 228 ].…”

Section: Weight Regain Following Bariatric Surgerymentioning

confidence: 99%

Physiological Appetite Regulation and Bariatric Surgery

Ramasamy

2024

JCM

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Obesity remains a common metabolic disorder and a threat to health as it is associated with numerous complications. Lifestyle modifications and caloric restriction can achieve limited weight loss. Bariatric surgery is an effective way of achieving substantial weight loss as well as glycemic control secondary to weight-related type 2 diabetes mellitus. It has been suggested that an anorexigenic gut hormone response following bariatric surgery contributes to weight loss. Understanding the changes in gut hormones and their contribution to weight loss physiology can lead to new therapeutic treatments for weight loss. Two distinct types of neurons in the arcuate hypothalamic nuclei control food intake: proopiomelanocortin neurons activated by the anorexigenic (satiety) hormones and neurons activated by the orexigenic peptides that release neuropeptide Y and agouti-related peptide (hunger centre). The arcuate nucleus of the hypothalamus integrates hormonal inputs from the gut and adipose tissue (the anorexigenic hormones cholecystokinin, polypeptide YY, glucagon-like peptide-1, oxyntomodulin, leptin, and others) and orexigeneic peptides (ghrelin). Replicating the endocrine response to bariatric surgery through pharmacological mimicry holds promise for medical treatment. Obesity has genetic and environmental factors. New advances in genetic testing have identified both monogenic and polygenic obesity-related genes. Understanding the function of genes contributing to obesity will increase insights into the biology of obesity. This review includes the physiology of appetite control, the influence of genetics on obesity, and the changes that occur following bariatric surgery. This has the potential to lead to the development of more subtle, individualised, treatments for obesity.

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Section: Weight Regain Following Bariatric Surgerymentioning

confidence: 99%

Physiological Appetite Regulation and Bariatric Surgery

Ramasamy

2024

JCM

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Exploring Molecular Genetics Research on Obesity in Malaysia: Protocol for a Scoping Review

Ahmad Zamri,

Abu Seman,

Zainal Abidin

et al. 2024

JMIR Res Protoc

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Background Obesity presents a growing challenge to public health, and its intricate association with genetics continues to be a compelling field of study. In countries such as Malaysia, where diverse genetic backgrounds converge, exploring the molecular genetics of obesity is even more imperative. Objective This scoping review aimed to explore the literature on molecular genetics of obesity in Malaysia. Specifically, we sought to characterize existing studies, identify the genetic determinants of obesity, and assess their association with obesity predisposition in the population. Methods This scoping review followed the methodology of the Joanna Briggs Institute and used the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist as its guiding framework. Searches were conducted using electronic databases such as PubMed, ScienceDirect, and Scopus, filtering for human studies published until March 2024. Eligible studies included peer-reviewed articles on the Malaysian population irrespective of age or sex. This review excluded review articles, book chapters, non–peer-reviewed conference proceedings, gray literature, and preclinical studies, and the reference lists of the retrieved studies were manually examined to ensure thorough inclusion. The articles were subjected to a 2-stage screening process (title/abstract and full text) conducted by 2 reviewers to assess eligibility. Eligible articles were then extracted following a data extraction framework and organized into a charting table. Only studies investigating the genetics of obesity in Malaysian populations were included. Results As of March 2024, our extensive search strategy has yielded 572 records. After removing 153 duplicates, 419 records were screened by title and abstract, resulting in 47 selected for full-text review. Of these, 34 were chosen for data extraction and detailed analysis. These studies predominantly involved participants from major ethnic groups (Malay, Chinese, and Indian) recruited from local health centers and university communities. The articles primarily explored the relationship between specific gene variants and obesity or obesity-related health parameters. This ongoing research is expected to be completed with a comprehensive scoping review by April 2025. Conclusions This review provides valuable insights into the genetic determinants of obesity in Malaysia, despite limitations such as no quality appraisal being conducted for the included studies and the search strategy being restricted to selected databases, potentially omitting relevant studies. However, this review ensured reliability and reproducibility by adhering to the Joanna Briggs Institute and PRISMA-ScR guidelines. Ultimately, this study advances the understanding of local research and sets the foundation for future molecular genetic studies to improve obesity risk prediction and management in Malaysia’s multiethnic population. International Registered Report Identifier (IRRID) DERR1-10.2196/60838

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Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery

Cited by 2 publications

References 43 publications

Physiological Appetite Regulation and Bariatric Surgery

Physiological Appetite Regulation and Bariatric Surgery

Exploring Molecular Genetics Research on Obesity in Malaysia: Protocol for a Scoping Review

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