Combined Effect of Hyperhomocysteinemia and Hypertension on the Presence of Early Carotid Artery Atherosclerosis

Zhang, Zhongying; Fang, Xianghua; Yang, Hua; Liu, Beibei; Ji, Xunming; Tang, Zhe; Wang, Chunxiu; Guan, Shaochen; Wu, Xia; Liu, Hongjun; Gu, Xiaoyan

doi:10.1016/j.jstrokecerebrovasdis.2016.01.037

Cited by 31 publications

(39 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zhao and colleagues claimed that the combination of hyperhomocysteinemia and hyperuricemia could result in accelerated atherosclerosis [2]. In addition, Zhang and colleagues confirmed that the coexistence of hyper-homocysteinemia and elevated blood pressure increased the risk of early atherosclerosis in the carotid artery [3]. The possible mechanisms may include a change in the total antioxidant status and regeneration of endothelial cells or a decrease in the synthesis of high-density lipoprotein [4].…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Chen

Yang

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54 ± 10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level > 15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height 2.7 (LVMH 2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23 ± 16.34 vs. 40.09 ± 10.55 g-2.7 , P < 0.001; males: 48.67 ± 12.24 g-2.7 vs. 42.42 ± 11.38 g-2.7 , P < 0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58 ± 31.92 g − 2 vs. 86.63 ± 20.47 g − 2 , P < 0.001; males: 106.10 ± 24.69 g − 2 vs. 98.16 ± 23.29 g − 2 , P < 0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P < 0.001, OR: 2.433 for LVMH 2.7 , P < 0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P < 0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH 2.7 , P < 0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Chen

Yang

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Plaque was denoted as a focal structure encroaching into the arterial lumen of >5 mm or 50% of the surrounding carotid intima-media thickness value or demonstrating a thickness > 1.5 mm as measured from the intima–lumen interface to the media–adventitia interface [12]. Plaques were detected on bilateral carotid bulbs.…”

Section: Methodsmentioning

confidence: 99%

Achieving low density lipoprotein-cholesterol < 70 mg/dL may be associated with a trend of reduced progression of carotid artery atherosclerosis in ischemic stroke patients

Zhang

Liu

et al. 2017

Journal of the Neurological Sciences

Self Cite

View full text Add to dashboard Cite

Objective To assess whether an intensive lipid-lowering strategy is more beneficial on atherosclerotic plaque progression in the stroke survivors. Methods We retrospectively assessed data that was prospectively collected on 106 ischemic stroke patients from one academic stroke center. Patients with various degrees of common carotid artery atherosclerosis were followed for one year. Patients were classified into intensive lipid-lowering therapy (ILLT) group if they achieve low-density lipoprotein cholesterol (LDL-c) < 70 mg/dL (n = 38) and conventional lipid-lowering therapy (CLLT) group if their LDL-c is within 70–120 mg/dL (n = 68) at end of one year. Carotid ultrasound was performed at baseline lipid-lowering therapy and at one year to characterize the plaques. Results Mean change in atherosclerotic plaque length was −1.4 mm (95% CI: [−4.1, 1, 2]; P = 0.27) in ILLT and 1.1 mm in CLLP group (95% CI: [−0.9, 3.1]; P = 0.27); no difference between groups (P = 0.40). Atherosclerotic plaque thickness decreased by 0.2 mm (95% CI: [−0.4, 0.03]; P = 0.09) in ILLT group; while in CLLT group, thickness increased by 0.02 mm after 1-year therapy (95%CI: [−0.1, 0.2]; P = 0.77); no difference between groups (P = 0.28). Conclusions Achieving LDL-c < 70 mg/dL in ischemic stroke patients was associated with a trend of reducing atherosclerotic plaque progression at one year. Future larger studies are warranted.

show abstract

“…These advanced carotid plaques resulted in a higher ischaemic stroke risk [102]. In the study by Zhang et al, raised serum homocysteine acted synergistically with hypertension; therefore there was a greater risk of having plaque in bilateral CCA [100]. Alvarez et al reported that in the patients with carotid stenosis of more than 70% and were receiving surgical management, high homocysteine level was present in the patients with extracranial cerebrovascular diseases [103].…”

Section: Homocysteine and Carotid Plaquementioning

confidence: 99%

“…The patients with serum homocysteine level > 15 μmol/L had increased risk of presence of carotid plaque and plaque in bilateral common carotid artery (CCA) [100]. An increase in serum homocysteine was independently associated with plaque morphology and larger plaque area [101].…”

Section: Homocysteine and Carotid Plaquementioning

confidence: 99%

Atherosclerosis at Extracranial Carotid Vessels and Serum Homocysteine

Tai¹,

Ong²,

Toh³

et al. 2019

Inflammatory Heart Diseases

View full text Add to dashboard Cite

In this chapter we will discuss more about the role of homocysteine in atherosclerosis and also association between serum homocysteine with extracranial carotid atherosclerosis. Carotid atherosclerosis comprises an increase in carotid intima-media (CIMT) thickening, plaque formation and carotid stenosis. Atherogenic property of homocysteine was discovered in 1969. Atherosclerosis is initiated by endothelial dysfunction. One of the causes of endothelial abnormality is homocysteine. The development of aggregates of homocysteinylated lipoproteins with microorganisms obstructs the vasa vasorum in vulnerable plaques. In one study, serum homocysteine in the highest quartile was independently associated with extracranial carotid artery stenosis ≥50%. In another study, raised serum homocysteine was also independently associated with severe extracranial carotid stenosis in both genders. In other studies, serum homocysteine was significantly associated with carotid artery stenosis in internal carotid arteries and external carotid arteries as well as the degree of stenosis. The hypertensive patients who had raised serum homocysteine were reported to have higher risk of developing asymptomatic extracranial carotid artery stenosis.

show abstract

Combined Effect of Hyperhomocysteinemia and Hypertension on the Presence of Early Carotid Artery Atherosclerosis

Cited by 31 publications

References 33 publications

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Achieving low density lipoprotein-cholesterol < 70 mg/dL may be associated with a trend of reduced progression of carotid artery atherosclerosis in ischemic stroke patients

Atherosclerosis at Extracranial Carotid Vessels and Serum Homocysteine

Contact Info

Product

Resources

About