Combined effect of IL‐10 and TGF‐β1 promoter polymorphisms as a risk factor for aspirin‐intolerant asthma and rhinosinusitis

Kim, Seung Hyun; Yang, Eun‐Mi; Lee, H.-N.; Cho, B.-Y.; Ye, Y.-M.; Park, Hae‐Sim

doi:10.1111/j.1398-9995.2009.01989.x

Cited by 53 publications

(25 citation statements)

References 21 publications

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“…Similar results were observed in asthmatics in a North Indian population (Chatterjee et al, 2005) and allergic patients (women) in a French population (Guglielmi et al, 2006), whereas aspirin-intolerant asthma and rhinosinusitis patients in Korean population (Kim et al, 2009), bronchial asthma in Macedonian population, and atopic dermatitis in European population showed no association (Trajkov et al, 2008;Lacy et al, 2009).…”

Section: Discussionsupporting

confidence: 84%

Association of Interleukin-10 Gene Promoter Polymorphism in Allergic Patients

Gaddam¹,

Priya²,

Babu³

et al. 2012

Genetic Testing and Molecular Biomarkers

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Section: Discussionsupporting

confidence: 84%

Association of Interleukin-10 Gene Promoter Polymorphism in Allergic Patients

Gaddam¹,

Priya²,

Babu³

et al. 2012

Genetic Testing and Molecular Biomarkers

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“…Three genetic variants (rs1800896, rs1800871, and rs1800872) in the IL-10 gene have been extensively investigated in relation to infectious diseases (9, 27, 34) and allergic conditions (11,20). We previously identified complete linkage between rs1800871 and rs1800872, and therefore in the present study we excluded rs1800871 and included an additional intronic IL-10 SNP rs1518110 (6).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

et al. 2012

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ABSTRACTThe role of interleukin-10 (IL-10) in malaria remains poorly characterized. The aims of this study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10 production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the IL-10 gene in young children and their mothers are associated with the incidence of clinical malaria in young children. We genotyped three IL-10 single nucleotide polymorphisms in 240 children and their mothers from a longitudinal prospective cohort and assessed the IL-10 production by maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs). Clinical episodes ofPlasmodium falciparummalaria in the children were documented until the second year of life. The polymorphism IL-10 A-1082G (GCC haplotype of three SNPs in IL-10) in children was associated with IL-10 production levels by CBMC cultured withP. falciparum-infected erythrocytes (P= 0.043), with the G allele linked to low IL-10 production capacity. The G allele in children was also significantly associated with a decreased risk for clinical malaria infection in their second year of life (P= 0.016). Furthermore, IL-10 levels measured in maternal PBMCs cultured with infected erythrocytes were associated with increased risk of malaria infection in young children (P< 0.001). In conclusion, IL-10 polymorphisms and IL-10 production capacity were associated with clinical malaria infections in young children. High IL-10 production capacity inherited from parents may diminish immunological protection againstP. falciparuminfection, thereby being a risk for increased malaria morbidity.

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“…The frequency of this SNP in combination with the -592A>G variant in TGF-1 was higher in AIA patients compared with those with good tolerance [131]. Two promoter polymorphisms of TNF-at -1031T>C and -863C>A have recently been suggested to contribute to the development of AIU [132].…”

Section: Genetic Studiesmentioning

confidence: 98%

Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs

Cornejo-García¹,

Blanca‐López²,

Doña³

et al. 2009

CDM

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NSAIDs are the most important group of drugs involved in hypersensitivity drug reactions, and include heterogeneous compounds with very different chemical structures. These reactions can be IgE dependent (immediate reactions), T cell-mediated (non-immediate), or induced by a non-specific immunological mechanism related with the blocking of the COX-1 enzyme and the shunting to the lipooxygenase pathway (cross-intolerant reactions). Cutaneous symptoms are the most frequent, with ibuprofen, naproxen and diclofenac being common culprit drugs worldwide, although others can be involved because patterns of consumption and exposure rates vary between countries. A very important proportion of immunological reactions are immediate, with urticaria and anaphylaxis being the typical clinical manifestations. Non-immediate reactions comprise a number of heterogeneous entities ranging from mild exanthema to severe TEN or DRESS syndrome, as well as organ-specific reactions such as hepatitis or pneumonitis. Cross-intolerant reactions appear to non-chemically related drugs, and involve respiratory airways, skin or both. In vivo diagnostic tests are based on the capacity of the skin to respond to the culprit drug, but their sensitivity is in many instances rather low. The approach for in vitro testing consists of either detecting specific IgE antibodies or studying the proliferation of T lymphocytes toward the eliciting drug. No appropriate tests are yet available for the in vitro validation of cross-intolerance reactions, although techniques based on the stimulation of basophils have been proposed. Based on these findings, the diagnostic approach is often based on the controlled administration of the drug to assess tolerance. In this work we review current knowledge on hypersensitivity reactions to NSAIDs, including diagnostic approach and genetic studies.

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Combined effect of IL‐10 and TGF‐β1 promoter polymorphisms as a risk factor for aspirin‐intolerant asthma and rhinosinusitis

Abstract: Our results suggest that IL-10 promoter polymorphisms contribute to the development of AIA and that rhinosinusitis may interact genetically with TGF-beta1.

Cited by 53 publications

References 21 publications

Association of Interleukin-10 Gene Promoter Polymorphism in Allergic Patients

Association of Interleukin-10 Gene Promoter Polymorphism in Allergic Patients

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs

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