2016
DOI: 10.1002/btpr.2389
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Combined effect of pulsed electromagnetic field and sound wave on In vitro and In vivo neural differentiation of human mesenchymal stem cells

Abstract: Biophysical wave stimulus has been used as an effective tool to promote cellular maturation and differentiation in the construction of engineered tissue. Pulsed electromagnetic fields (PEMFs) and sound waves have been selected as effective stimuli that can promote neural differentiation. The aim of this study was to investigate the synergistic effect of PEMFs and sound waves on the neural differentiation potential in vitro and in vivo using human bone marrow mesenchymal stem cells (hBM-MSCs). In vitro, neural-… Show more

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Cited by 10 publications
(5 citation statements)
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References 58 publications
(128 reference statements)
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“…Even though, the effect on calcium efflux and cell differentiation were also proved [51,52]. On the other hand, several in vitro studies did not find any significant effect of EMF exposure on cell differentiation, neither on phagocytosis or chemotaxis [53,54].…”
Section: Discussionmentioning
confidence: 96%
“…Even though, the effect on calcium efflux and cell differentiation were also proved [51,52]. On the other hand, several in vitro studies did not find any significant effect of EMF exposure on cell differentiation, neither on phagocytosis or chemotaxis [53,54].…”
Section: Discussionmentioning
confidence: 96%
“…Previous work by our group and others reported the effects of mechanical stimulation in hMSCs [21][22][23][24]. Neural differentiation of hMSCs was induced by sonic vibration or/and electromagnetic fields, allowing therapeutic applications in models of spinal cord injury and ischemic stroke [25,26]. This mechanical stimulation equally induced neural differentiation of hMSCs, and in particular, morphological changes similar to the neural cell shape were dramatically induced by sub-sonic vibrations [21].…”
Section: Introductionmentioning
confidence: 90%
“…Previous work by our group and others reported the effects of stimulation in hMSCs [21][22][23][24]. Neural differentiation of hMSCs was induc vibration or/and electromagnetic fields, allowing therapeutic applications in spinal cord injury and ischemic stroke [25,26]. This mechanical stimulat induced neural differentiation of hMSCs, and in particular, morphologi similar to the neural cell shape were dramatically induced by sub-sonic vibrat the present study, we aimed to investigate key genes involved in this differ low-intensity sub-sonic vibration (LISSV) through RNA sequencing base generation sequencing.…”
Section: Rna Sequencing Confirmed That Six Genes Were Increased By Lissvmentioning
confidence: 95%
“…Given the positive influence of both (sub)­sonic vibrations and ELF-EMF on stem cell lineage commitment, a combination of both these may have an additive effect. In view of this, combining pulsed EMF and sound waves was shown to be effective stimuli that can promote neural cell therapy . Collectively, these studies suggest an emerging role of sonic vibration and electromagnetic fields for stem cell lineage commitment.…”
Section: Lineage Commitment Induced By Nonconventional Mechanical Sig...mentioning
confidence: 97%
“…In view of this, combining pulsed EMF and sound waves was shown to be effective stimuli that can promote neural cell therapy. 134 Collectively, these studies suggest an emerging role of sonic vibration and electromagnetic fields for stem cell lineage commitment. The Wnt/βcatenin signaling pathway appears to be activated in response to EMF stimuli leading to osteogenesis of MSCs 135 4.2.…”
Section: Lineage Commitment Induced Bymentioning
confidence: 98%