Combined effects of abamectin and temperature on the physiology and behavior of male lizards (Eremias argus): Clarifying adaptation and maladaptation

Nie, Yufan; Wang, Zikang; Yu, Simin; Liu, Yuping; Zhang, Luyao; Li, Rui; Zhou, Zhiqiang; Zhu, Wentao; Diao, Jinling

doi:10.1016/j.scitotenv.2022.155794

Cited by 10 publications

(6 citation statements)

References 74 publications

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“…Moreover, flufiprole treatment at higher temperatures caused higher MDA or 8-OHdG contents in lizards, which suggested more serious oxidative toxicity during global warming. Similar to our results, the MDA content in lizard brain was also significantly increased after abamectin exposure and further increased under higher temperatures . The in vitro assay indicated that fipronil sulfone and fipronil desulfinyl were more toxic than their parent compound regarding oxidative stress .…”

Section: Resultssupporting

confidence: 89%

“…Similar to our results, the MDA content in lizard brain was also significantly increased after abamectin exposure and further increased under higher temperatures. 49 The in vitro assay indicated that fipronil sulfone and fipronil desulfinyl were more toxic than their parent compound regarding oxidative stress. 42 Flufiprole sulfone rather than flufiprole caused a significant increase in the MDA content in algae (Chlorella pyrenoidosa).…”

Section: Gene Expression Levels Of Metabolic Enzymes In Lizard Livermentioning

confidence: 99%

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Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Chang,

An,

Xie

et al. 2023

Environ. Sci. Technol.

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As a phenylpyrazole insecticide, flufiprole is an important substitute for fipronil in the agricultural field of China. However, its bioaccumulation and metabolism in terrestrial organisms especially in the lizards living in the agricultural area have rarely been investigated. As an ectothermic animal, lizards are also sensitive to temperature changes. Considering global warming, this study measured bioaccumulation, metabolism, and hepatotoxicity of flufiprole in the Chinese native lizard (Eremias argus) under different temperature stresses. Lizards exposed to flufiprole-contaminated soil adsorbed flufiprole through the skin and flufiprole was preferred to accumulate in lizard liver and brain. The oxidation product fipronil sulfone was the main metabolite of flufiprole in both lizard liver and human liver microsomes, which were mainly metabolized by lizard CYP3A19 or human CYP3A4. The fipronil sulfone concentration increased with increased temperature in lizard tissues. In addition, more serious oxidative damage was shown under higher temperature as the glutathione (GSH), malondialdehyde (MDA), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in lizards increased with increased temperature after flufiprole exposure. Flufiprole exposure also induced lizard liver lesions, and these lesions became more serious in the higher-temperature groups. This study provided new insights into the risk assessment of flufiprole in lizards under global warming.

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Section: Resultssupporting

confidence: 89%

Section: Gene Expression Levels Of Metabolic Enzymes In Lizard Livermentioning

confidence: 99%

Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Chang,

An,

Xie

et al. 2023

Environ. Sci. Technol.

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“…Image created with Biorender.com. alters the toxicity of pesticides in insects (Verheyen et al, 2022) and HS was additive to the negative impacts of abamectin exposure in Chinese lizards (Nie et al, 2022). Whether these findings translate fully to production animals remains undefined.…”

Section: Hs and Chemical Exposurementioning

confidence: 99%

“…The core body temperature of firefighters is elevated (Menze et al, 1996) and, in terms of reproduction, detrimental impacts on male gamete quality occur in male firefighters (Engelsman et al, 2021). In nonhuman species, fluctuations in daily temperatures alters the toxicity of pesticides in insects (Verheyen et al, 2022) and HS was additive to the negative impacts of abamectin exposure in Chinese lizards (Nie et al, 2022). Whether these findings translate fully to production animals remains undefined.…”

Section: Toxicant Exposures With Impacts On Swine Reproductionmentioning

confidence: 99%

Scrambled eggs—Negative impacts of heat stress and chemical exposures on ovarian function in swine

González-Alvarez

Roach

Keating

2023

Molecular Reproduction Devel

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Exposure to environmental toxicants and hyperthermia can hamper reproduction in female mammals including swine. Phenotypic manifestations include poor quality oocytes, endocrine disruption, infertility, lengthened time to conceive, pregnancy loss, and embryonic defects. The ovary has the capacity for toxicant biotransformation, regulated in part by the phosphatidylinositol‐3 kinase signaling pathway. The impacts of exposure to mycotoxins and pesticides on swine reproduction and the potential for an emerging chemical class of concern, the per‐ and polyfluoroalkylated substances, to hamper porcine reproduction are reviewed. The negative impairments of heat stress (HS) on swine reproductive outcomes are also described and the cumulative effect of environmental exposures, such as HS, when present in conjunction with a toxicant is considered.

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“…However, lizards jointly exposed to abamectin and heat stress simultaneously face elevated MR and repair costs linked to contaminant and heat exposure, and decreased locomotion and predatory performance caused by contamination. Under this extreme stress, lizards shift to display a heat‐avoidance reaction, resulting in a positive synergistic effect on thermal shelter use, which is a short‐term means of conserving energy, but might ultimately compromise energy balance (Nie et al, 2022).…”

Section: Interactive Effects Across Bioenergetic Domainsmentioning

confidence: 99%

Combined threats of climate change and contaminant exposure through the lens of bioenergetics

Grunst

Grémillet

et al. 2023

Global Change Biology

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Organisms face energetic challenges of climate change in combination with suites of natural and anthropogenic stressors. In particular, chemical contaminant exposure has neurotoxic, endocrine‐disrupting, and behavioral effects which may additively or interactively combine with challenges associated with climate change. We used a literature review across animal taxa and contaminant classes, but focused on Arctic endotherms and contaminants important in Arctic ecosystems, to demonstrate potential for interactive effects across five bioenergetic domains: (1) energy supply, (2) energy demand, (3) energy storage, (4) energy allocation tradeoffs, and (5) energy management strategies; and involving four climate change‐sensitive environmental stressors: changes in resource availability, temperature, predation risk, and parasitism. Identified examples included relatively equal numbers of synergistic and antagonistic interactions. Synergies are often suggested to be particularly problematic, since they magnify biological effects. However, we emphasize that antagonistic effects on bioenergetic traits can be equally problematic, since they can reflect dampening of beneficial responses and result in negative synergistic effects on fitness. Our review also highlights that empirical demonstrations remain limited, especially in endotherms. Elucidating the nature of climate change‐by‐contaminant interactive effects on bioenergetic traits will build toward determining overall outcomes for energy balance and fitness. Progressing to determine critical species, life stages, and target areas in which transformative effects arise will aid in forecasting broad‐scale bioenergetic outcomes under global change scenarios.

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Combined effects of abamectin and temperature on the physiology and behavior of male lizards (Eremias argus): Clarifying adaptation and maladaptation

Cited by 10 publications

References 74 publications

Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Scrambled eggs—Negative impacts of heat stress and chemical exposures on ovarian function in swine

Combined threats of climate change and contaminant exposure through the lens of bioenergetics

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