Combined effects of high-fat feeding and circadian desynchronization

Bartol-Munier, I.; Gourmelen, Sylviane; Pévet, Paul; Challet, Étienne

doi:10.1038/sj.ijo.0803048

Cited by 52 publications

(34 citation statements)

References 31 publications

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“…24 A similar effect has been observed in rats. 25 Although previously shown in rats, 9 to our knowledge, a novel discovery from this study was the direct link between oestrus and running distance, which had not been reported earlier for laboratory mice. Earlier studies have shown that the female golden hamster runs further during preoestrus and oestrus than postoestrus, 26 whereas female rats run most before oestrus and least immediately after.…”

mentioning

confidence: 86%

Wheel running in female C57BL/6J mice: impact of oestrus and dietary fat and effects on sleep and body mass

2009

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Objective: To examine the impact of two diets differing in fat content and of wheel-running exercise on body mass. Methods: A total of 32 female C57BL/6J mice were assigned to either a high-fat (HF, 41% of dietary energy as fat) or low-fat (LF, 11% of dietary energy as fat) diet (16 per diet, individually housed). Eight mice from each diet group were housed with running wheels. Non-running mice were housed in similar cages, without wheels. Total cage activity (including non-exercise physical activity þ wheel running) and sleep time were also measured using an infra-red-sensing device. Oestrus stage of the wheel-running mice was assessed daily for 17 days. Results: After 8 weeks, HF mice were significantly heavier than LF mice (P ¼ 0.004), but there was no detectable difference in body fat mass. Wheel-running mice tended to have a lower body mass than non-running controls (P ¼ 0.056). Voluntary cage activity was greater in LF control mice than HF control mice, and in wheel-running mice compared with non-wheel-running mice. HF control mice slept more than LF control mice. Stage of oestrus was significantly correlated with running distance, with mice running farthest in the immediate preoestrus phase and least immediately after oestrus. Conclusion: This study shows that HF diets in female C57BL/6J mice may increase sleep time similar to the effect of daytime sleepiness observed in obese humans.

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mentioning

confidence: 86%

Wheel running in female C57BL/6J mice: impact of oestrus and dietary fat and effects on sleep and body mass

2009

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“…A number of different types of high-fat and/or highenergy diets have already been used to induce obesity and/or mimic the human metabolic syndrome in rodents [12][13][14][15][16][17]. Most studies have used only one high-fat formula compared with the standard chow diet.…”

Section: Dietmentioning

confidence: 98%

“…[15]) or Long-Evans (e.g. [14,17]) rats. The increase in body mass obtained in the present study with both HFD1 (i.e.…”

Section: Figure 5 Plasma Adiponectin (A and B) And Leptin (C And D) Ementioning

confidence: 99%

Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats

et al. 2007

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Metabolic disorders induced by high-fat feeding in rodents evoke some, if not all, of the features of human metabolic syndrome. The occurrence and severity of metabolic disorders, however, varies according to rodent species, and even strain, as well as the diet. Therefore, in the present study, we investigated the long-term obesogenic and diabetogenic effects of three high-fat diets differing by their fat/carbohydrate ratios. Sprague-Dawley rats were fed a control high-carbohydrate and low-fat diet [HCD; 3:16:6 ratio of fat/carbohydrate/protein; 15.48 kJ/g (3.7 kcal/g)], a high-fat and medium-carbohydrate diet [HFD1; 53:30:17 ratio of fat/carbohydrate/protein; 19.66 kJ/g (4.7 kcal/g)], a very-high-fat and low-carbohydrate diet [HFD2; 67:9:24 ratio of fat/carbohydrate/protein; 21.76 kJ/g (5.2 kcal/g)] or a very-high-fat and carbohydrate-free diet [HFD3; 75:0:25 ratio of fat/carbohydrate/protein; 24.69 kJ/g (5.9 kcal/g)] for 10 weeks. Compared with the control diet (HCD), rats fed with high-fat combined with more (HFD1) or less (HFD2) carbohydrate exhibited higher BMI (body mass index; +13 and +10% respectively; P<0.05) and abdominal fat (+70% in both HFD1 and HFD2; P<0.05), higher plasma leptin (+130 and +135% respectively; P<0.05), lower plasma adiponectin levels (-23 and -30% respectively; P<0.05) and impaired glucose tolerance. Only the HFD1 group had insulin resistance. By contrast, a very-high-fat diet devoid of carbohydrate (HFD3) led to impaired glucose tolerance, insulin resistance and hypoadiponectinaemia (-50%; P<0.05), whereas BMI, adiposity and plasma leptin did not differ from respective values in animals fed the control diet. We conclude that increasing the fat-to-carbohydrate ratio to the uppermost (i.e. carbohydrate-free) in a high-fat diet prevents the development of obesity, but not the prediabetic state (i.e. altered glucose tolerance and insulin sensitivity).

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“…Les effets délé-tères de la désynchronisation chronique sur la santé méta-bolique ont été identifiés chez les animaux. Les rats exposés à un changement bihebdomadaire du cycle lumière-obscurité pendant 3 mois sont en surpoids et présentent une diminution de la sécrétion d'insuline par rapport à des animaux maintenus dans un cycle lumière-obscurité fixe [28,29]. Une autre étude a également montré que la désynchronisa-tion circadienne par le jetlag chronique accélère la survenue du diabète chez des rats transgéniques qui développent un diabète de type 2 avec l'âge [30].…”

Section: Pathologieunclassified

Interactions entre rythmicité circadienne et métabolisme

Challet

2015

Obes

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La plupart des fonctions biologiques, y compris le métabolisme, présentent une rythmicité circadienne. Cette organisation temporelle est contrôlée par une horloge principale dans les noyaux suprachiasmatiques, mise à l'heure par la lumière et des horloges secondaires dans les tissus péri-phériques, synchronisées par l'horloge suprachiasmatique et l'heure du repas. Des régimes hypocaloriques ou, inversement, hyperlipidiques agissent de manière différentielle sur l'horloge suprachiasmatique. Les pathologies métaboliques sont fréquemment associées à des troubles circadiens. Au contraire, la désynchronisation circadienne perturbe le méta-bolisme en favorisant le surpoids et une détérioration de la tolérance au glucose.Mots clés Horloge circadienne · Heure des repas · Obésité · Diabète · Travail posté · Jetlag Abstract Most biological functions, including metabolism, display circadian rhythms. This temporal order is controlled by the master clock in the suprachiasmatic nuclei, mainly reset by ambient light, and secondary clocks in peripheral tissues, synchronized by the master clock and mealtime. Calorie restriction or high-fat feeding differentially modify the suprachiasmatic clockwork. Metabolic pathologies are frequently associated with circadian disorders. Conversely, circadian desynchronization negatively impacts metabolism by triggering increased adiposity and impaired glucose tolerance.

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Combined effects of high-fat feeding and circadian desynchronization

Cited by 52 publications

References 31 publications

Wheel running in female C57BL/6J mice: impact of oestrus and dietary fat and effects on sleep and body mass

Wheel running in female C57BL/6J mice: impact of oestrus and dietary fat and effects on sleep and body mass

Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats

Interactions entre rythmicité circadienne et métabolisme

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