Combined effects of office and 24-h blood pressure on aortic stiffness in human hypertension

Schillaci, Giuseppe; Pucci, Giacomo; Pirro, Matteo; Settimi, Laura; Hijazi, R.; Franklin, Stanley S.; Mannarino, Elmo

doi:10.1097/hjh.0b013e328344da49

Cited by 39 publications

(22 citation statements)

References 39 publications

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“…In the present cohort, the overall test agreement of the SpygmoCor compared to the Complior device was 'poor' when we corrected for the anatomical distance, and 'acceptable' with uncorrected cfPWV values. Hypertension and obesity are closely related to increased aortic stiffness [31][32][33][34], but our study shows that increasing BP and BMI levels lead to a weaker concordance between the two measurement methods. In fact, the test agreement of the devices was poor in the highest BP group and in obese patients, regardless of correcting the cfPWV values obtained by SphygmoCor.…”

Section: Discussioncontrasting

confidence: 55%

Carotid–femoral pulse wave velocity assessment by two different methods

Pichler

Martínez²,

Vicente

et al. 2015

Journal of Hypertension

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Section: Discussioncontrasting

confidence: 55%

Carotid–femoral pulse wave velocity assessment by two different methods

Pichler

Martínez²,

Vicente

et al. 2015

Journal of Hypertension

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“…19 It seems that the increase in PWV with BP is not simply attributable to the increase in BP with age. 20,21 The observed progressive increment of PWV with systolic BP elevation present early in life, and even in the high-normal subjects, raised the question about the nature and significance of the increment. One possibility is that PWV reflects functional or even structural changes in the vascular wall structure as part of the evolving hypertension process and so is a harbinger of further future BP elevation.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure and Obesity Exert Independent Influences on Pulse Wave Velocity in Youth

et al. 2012

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Abstract-The objective was to analyze pulse wave velocity (PWV) in normotensive, high-normal, and hypertensive youths by using aortic-derived parameters from peripheral recordings. The impact of obesity on vascular phenotypes was also analyzed. A total of 501 whites from 8 to 18 years of age were included. The subjects were divided according to BP criteria: 424 (85%) were normotensive, 56 (11%) high-normal, and 21 (4%) hypertensive. Obesity was present in 284 (56%) and overweight in 138 (28%). Pulse wave analysis using a SphygmoCor device was performed to determine central blood pressure (BP), augmentation index, and measurement of PWV. Among the BP groups, differences appeared in age, sex, and height but not in body mass index. Significant differences in peripheral and central systolic and diastolic BPs and pulse pressures were observed within groups. A graded increase in PWV was present across the BP strata without differences in augmentation index. Using a multiple regression analysis, age, BP groups, and obesity status were independently associated with PWV. Older and hypertensive subjects had the highest PWV, whereas, from normal weight status to obesity, PWV decreased. Likewise, PWV was positively related to peripheral or central systolic BP and negatively related to body mass index z score. For 1 SD of peripheral systolic BP, PWV increased 0.329 m/s, and for 1 SD of body mass index z score PWV decreased 0.129 m/s. In conclusion, PWV is increased in hypertensive and even in high-normal children and adolescents. Furthermore, obesity, the factor most frequently related to essential hypertension in adolescents, blunted the expected increment in PWV of hypertensive and high-normal subjects. (Hypertension. 2012;60:550-555.)Key Words: hypertension Ⅲ obesity Ⅲ children Ⅲ adolescents Ⅲ augmentation index Ⅲ pulse wave velocity C ardiovascular damage occurring in adults finds its roots in risk factors operating early in life. Among the factors influencing cardiovascular risk, blood pressure (BP) values represent an important measurable marker of the level of potential cardiovascular risk in children and adolescents. The need to identify cardiovascular risk factors, including high BP, in youth, is acknowledged more and more frequently. Consequently, measurement of BP has become a routine part of pediatric care, and asymptomatic hypertension is now detected in pediatric care practice.BP phenotype is determined not only by conventional risk factors but also by weight gain in childhood. The adverse effects of excessive weight gain on BP and the association of weight gain with higher incidence of BP elevation represent major issues in health care.1-5 Elevation of systolic and/or diastolic BP indicates high BP in the child. In addition, children and adolescents with mild BP elevation, in the high-normal range, are much more common than was thought in the past, ranging from 3.4% to 15.7%. 6,7 Rather than having a goal of classifying children as high-normal, we should be identifying those who may be at risk for the developm...

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“…In addition to studies that showed the predictive value of exaggerated exercise BP response, there has been a study that white-coat hypertension is likely to progress to sustained hypertension [15]. In a recent study, both office and out-of-office BP were significant predictors of aortic PWV, independent of each other [16]. Similarly, resting BP and exercise SBP may affect arterial stiffness independently, although there may be some discrepancy between the two components.…”

Section: Discussionmentioning

confidence: 99%

The relationship between arterial stiffness and increase in blood pressure during exercise in normotensive persons

Sung

Choi

et al. 2012

Journal of Hypertension

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Combined effects of office and 24-h blood pressure on aortic stiffness in human hypertension

Abstract: Both office and out-of-office BP are independent predictors of aortic PWV in hypertension. Elevated BP values over the 24 h are associated with increased isobaric aortic stiffness.

Cited by 39 publications

References 39 publications

Carotid–femoral pulse wave velocity assessment by two different methods

Carotid–femoral pulse wave velocity assessment by two different methods

Blood Pressure and Obesity Exert Independent Influences on Pulse Wave Velocity in Youth

The relationship between arterial stiffness and increase in blood pressure during exercise in normotensive persons

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