Combined effects of ovariectomy and streptozotocin-induced diabetes in the articular cartilage of rats

Fernandes, AT; Fonseca, Cláudio César; Sasso, Gisela Rodrigues da Silva; Cezar, Luana Carvalho; Santos, Miriam Aparecida dos; Simões, Manuel J.; Simões, Ricardo Santos; Florencio‐Silva, Rinaldo

doi:10.1080/13697137.2017.1410782

Climacteric

2017

DOI: 10.1080/13697137.2017.1410782

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Combined effects of ovariectomy and streptozotocin-induced diabetes in the articular cartilage of rats

AT Fernandes

Cláudio César Fonseca

Gisela Rodrigues da Silva Sasso

et al.

Abstract: Our results indicate that the combination of ovariectomy and streptozotocin-induced diabetes produces more deleterious effects in articular cartilage of rats than either condition alone.

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Cited by 5 publications

References 38 publications

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Possible role of annexin A1/FPR2 pathway in COX2/NLRP3 inflammasome regulation in alveolar bone cells of estrogen‐deficient female rats with diabetes mellitus

Sasso,

Cerri,

Sasso‐Cerri

et al. 2023

Journal of Periodontology

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BackgroundAnnexin A1 (ANXA1) and the NOD‐like receptor family pyrin domain‐containing protein 3 (NLRP3) inflammasome play important roles in bone remodeling. However, expression profiles of these factors in bone cells under diabetes mellitus (DM) and estrogen‐deficient conditions are poorly understood. This study investigated the immunoexpression of ANXA1 and its formyl peptide receptor 2 (FPR2), as well as NLRP3 inflammasome mediators, during remodeling of the alveolar process in diabetic and estrogen‐deficient rats.MethodsTwenty adult female Wistar rats were divided into four groups (n = 5): Sham‐operated (SHAM) and ovariectomized (OVX) rats received a vehicle solution, and SHAM and OVX rats were intraperitoneally administered 60 mg/kg/body weight (BW) of streptozotocin (STZ) to induce DM (SHAM‐Di and OVX‐Di groups). After 7 weeks, the rats were euthanized and their maxillae were fixed in phosphate‐buffered 4% formaldehyde and embedded in paraffin. Sections were stained with hematoxylin/eosin (H&E) and picrosirius red or subjected to immunohistochemical detection of ANXA1, FPR2, NLRP3, interleukin‐1β (IL‐1β), and cyclooxygenase‐2 (COX2).ResultsEstrogen deficiency and DM were associated with deleterious effects in bone tissue, as evidenced by a lower number of osteocytes and higher number of empty lacunae in the SHAM‐Di and OVX‐Di groups compared to the nondiabetic groups. Both diabetic groups showed a smaller vascular area and weaker collagen fiber birefringence intensity in alveolar bone tissue. A significantly higher number of ANXA1/FPR2‐positive osteoblasts, osteocytes, and osteoclasts was accompanied by a significantly higher number of these cells immunolabeled for COX2, NLRP3, and IL‐1β in the diabetic and OVX groups, especially in both estrogen‐deficient and diabetic rats.ConclusionThese results indicate a possible role for the ANXA1/FPR2 pathway as a fine‐tuning/anti‐inflammatory regulator to counterbalance exacerbated COX2/NLRP3/IL‐1β activation in bone cells during bone remodeling under estrogen deficiency and DM.

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Possible role of annexin A1/FPR2 pathway in COX2/NLRP3 inflammasome regulation in alveolar bone cells of estrogen‐deficient female rats with diabetes mellitus

Sasso,

Cerri,

Sasso‐Cerri

et al. 2023

Journal of Periodontology

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show abstract

Effects of estrogen deficiency followed by streptozotocin-induced diabetes on periodontal tissues of female rats

et al. 2020

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Relationship between autophagy and NLRP3 inflammasome during articular cartilage degradation in oestrogen-deficient rats with streptozotocin-induced diabetes

Florencio-Silva,

Sasso,

Sasso-Cerri

et al. 2025

Annals of Anatomy - Anatomischer Anzeiger

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Combined effects of ovariectomy and streptozotocin-induced diabetes in the articular cartilage of rats

Abstract: Our results indicate that the combination of ovariectomy and streptozotocin-induced diabetes produces more deleterious effects in articular cartilage of rats than either condition alone.

Cited by 5 publications

References 38 publications

Possible role of annexin A1/FPR2 pathway in COX2/NLRP3 inflammasome regulation in alveolar bone cells of estrogen‐deficient female rats with diabetes mellitus

Possible role of annexin A1/FPR2 pathway in COX2/NLRP3 inflammasome regulation in alveolar bone cells of estrogen‐deficient female rats with diabetes mellitus

Effects of estrogen deficiency followed by streptozotocin-induced diabetes on periodontal tissues of female rats

Relationship between autophagy and NLRP3 inflammasome during articular cartilage degradation in oestrogen-deficient rats with streptozotocin-induced diabetes

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