Combined Effects of Pressure and Ionic Strength on Protein–Protein Interactions: An Empirical Approach
Brian Paul,
Eric M. Furst,
Abraham M. Lenhoff
et al.
Abstract:Proteins are exposed to hydrostatic pressure (HP) in a variety of ecosystems as well as in processing steps such as freeze−thaw, cell disruption, sterilization, and homogenization, yet pressure effects on protein−protein interactions (PPIs) remain underexplored. With the goal of contributing toward the expanded use of HP as a fundamental control parameter in protein research, processing, and engineering, small-angle X-ray scattering was used to examine the effects of HP and ionic strength on ovalbumin, a model… Show more
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