Combined effects of salinity and polystyrene microplastics exposure on the Pacific oysters Crassostrea gigas: Oxidative stress and energy metabolism

Du, Yunchao; Zhao, Jianmin; Jiang, Teng; Ren, Jinchang; Shan, Encui; Zhu, Xiaopeng; Zhang, Wenjing; Wang, Lei; Hou, Chaowei; Wang, Qing

doi:10.1016/j.marpolbul.2023.115153

Cited by 17 publications

(4 citation statements)

References 87 publications

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“…Overall, metabolic pathway analysis conducted in this study revelaed that PS MP exposure interfered with hepatopancreatic metabolism of crustaceans, even at a very low exposure level, mainly affecting glycolysis, lipolysis, and amino acid metabolism [125]. Furthermore, evidence was reported about the potential of PS MPs to alter the energy metabolism and osmotic adjustment pathway in the gills of Pacific oyster C. gigas exposed to 1 × 10 4 /L spherical PS MPs of different sizes (small PS MPs 6 µm, large PS MPs 0-60 µm) under three salinity levels (21,26, and 31 practical salinity units (psu)) for 14 days [123]. In detail, it was reported that oysters exposed to MPs were not able to effectively counteract oxidative stress, and overall they exhibited a higher resistance to combined exposure of low salinity and MPs.…”

Section: Effects Of Ps Mnps On the Metabolome Of Aquatic Invertebratesmentioning

confidence: 99%

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Eliso,

Billè,

Cappello

et al. 2024

Fishes

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In recent years, micro- and nanoplastics (MNPs) have represented an emerging threat for the aquatic environment due to their persistence and widespread distribution. Indeed, their small size and increased surface area lead to a high biological reactivity, which can be crucial for the health status of biota. To date, several studies have investigated lethal and sublethal endpoints of MNPs, while one of the main challenges is to understand their mechanisms of toxicity in a comprehensive manner. With this aim, the field of aquatic ecotoxicology can now benefit from the -omics approaches. This review focuses on the recent advances related to the use of transcriptomics, proteomics, and metabolomics to deeply investigate the molecular and biochemical responses of aquatic organisms, both fishes and aquatic invertebrates, to pristine polystyrene (PS) MNPs. The literature reviewed revealed that transcriptomics and metabolomics are the most frequently used -omic approaches. Overall, the studies taken into consideration shed light on the events triggered by PS MNPs at molecular and cellular levels, identifying as mechanisms of toxicity the pathways involved in oxidative stress, energy metabolism, immune response, and the nervous system. Future studies should therefore focus on the use and integration of multi-omics approaches for a more comprehensive understanding of the mechanisms involved in MNPs toxicity.

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Section: Effects Of Ps Mnps On the Metabolome Of Aquatic Invertebratesmentioning

confidence: 99%

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Eliso,

Billè,

Cappello

et al. 2024

Fishes

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“…While phenylalanine is an essential amino acid (or it cannot be synthesized by humans), Trp is considered a conditionally indispensable amino acid because it can be synthesized by the hydroxylation of phenylalanine by the enzyme phenylalanine hydroxylase [45]. It easily induces the biosynthesis pathways (phenylalanine, tyrosine, and tryptophan biosynthesis) in adverse conditions, which involves the regulation of energy metabolism [45][46][47]. Similar results were also observed in the present study, where the expression of eight metabolites, including phenylalanine and Trp significantly decreased the regulation of amino acid metabolism under low-salinity conditions.…”

Section: Effects Of Low-salinity Stress On Phenylalanine Tyrosine And...mentioning

confidence: 99%

Effects of Low-Salinity Stress on Histology and Metabolomics in the Intestine of Fenneropenaeus chinensis

Tian,

Wang,

Gao

et al. 2024

Animals

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Metabolomics has been used extensively to identify crucial molecules and biochemical effects induced by environmental factors. To understand the effects of acute low-salinity stress on Fenneropenaeus chinensis, intestinal histological examination and untargeted metabonomic analysis of F. chinensis were performed after exposure to a salinity of 15 ppt for 3, 7, and 14 d. The histological examination revealed that acute stress resulted in most epithelial cells rupturing, leading to the dispersion of nuclei in the intestinal lumen after 14 days. Metabolomics analysis identified numerous differentially expressed metabolites (DEMs) at different time points after exposure to low-salinity stress, in which some DEMs were steadily downregulated at the early stage of stress and then gradually upregulated. We further screened 14 overlapping DEMs, in which other DEMs decreased significantly during low-salinity stress, apart from L-palmitoylcarnitine and vitamin A, with enrichments in phenylalanine, tyrosine and tryptophan biosynthesis, fatty acid and retinol metabolism, and ABC transporters. ABC transporters exhibit significant abnormalities and play a vital role in low-salinity stress. This study provides valuable insights into the molecular mechanisms underlying the responses of F. chinensis to acute salinity stress.

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“…Similarly, to other transitional environments, these two Italian lagoons face a growing threat: MP accumulation. Bivalves like oysters filter feed at the water’s surface, making them susceptible to ingesting MPs [ 15 , 21 , 22 ]. This is why they are valuable bioindicators, allowing the assessment of MP contamination levels by measuring their accumulation in oyster tissues [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Bivalves like oysters filter feed at the water’s surface, making them susceptible to ingesting MPs [ 15 , 21 , 22 ]. This is why they are valuable bioindicators, allowing the assessment of MP contamination levels by measuring their accumulation in oyster tissues [ 21 , 22 , 23 ]. While the risks of human consumption of these MP-accumulating oysters are still under investigation [ 24 ], this study, alongside that of Provenza et al [ 25 ], aims to bridge that knowledge gap.…”

Section: Introductionmentioning

confidence: 99%

Navigating a Microplastic Sea: How the Pacific Cupped Oyster (Magallana gigas) Respond to Microplastic Pollution in Lagoons

De Rinaldis,

Pastorino,

Scirocco

et al. 2024

Toxics

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Microplastic pollution poses an escalating concern, particularly in coastal lagoons rich in biodiversity. This study delved into the occurrence of microplastics (MPs) in Magallana gigas (formerly Crassostrea gigas) from the Orbetello and Varano coastal lagoons (Italy), also investigating the response of these filter-feeding organisms to various colors (P = pink; B = blue; W = white) of high-density polyethylene (HDPE) MP fragments. Oysters were exposed for 7 days under controlled conditions. Subsequently, the oysters underwent analysis for both MP presence and biochemical markers of oxidative stress. Diverse ingestion rates of HDPE were noted among oysters from the two lagoons, eliciting antioxidant responses and modifying baseline activity. The two-way ANOVA revealed the significant effects of treatment (control; HDPE_B; HDPE_P; HDPE_W), site, and the interaction between treatment and site on all biomarkers. Non-metric multidimensional scaling showed a divergent effect of HDPE color on biomarkers. Further investigation is warranted to elucidate the mechanisms underlying the influence of MP color, dose-dependent effects, and the long-term impacts of exposure. Comprehending these intricacies is imperative for devising effective strategies to mitigate plastic pollution and safeguard marine health.

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Combined effects of salinity and polystyrene microplastics exposure on the Pacific oysters Crassostrea gigas: Oxidative stress and energy metabolism

Cited by 17 publications

References 87 publications

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Effects of Low-Salinity Stress on Histology and Metabolomics in the Intestine of Fenneropenaeus chinensis

Navigating a Microplastic Sea: How the Pacific Cupped Oyster (Magallana gigas) Respond to Microplastic Pollution in Lagoons

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