Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case–control study in China

Jin, Yaqing; Zhang, Chenye; Xu, Hongwei; Xue, Song; Wang, Yasong; Hou, Yayi; Kong, Yunming; Xu, Yingchun

doi:10.1016/j.canep.2010.06.004

Cited by 40 publications

(25 citation statements)

References 25 publications

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“…The use of metals for diagnosis is more scarce, but several authors have classified lung cancer patients and healthy people using metals content in tumor tissues [71,72], serum, hair [24,73], urine [74], and bronchoalveolar lavage fluid (BALF) [75], because they found statistically significant differences from the normal distribution of elements for the diagnosis of LC. Then, in the literature, it is possible to find levels of essential and non-essential elements in different biofluids and tissues of lung cancer (LC) patients, for example in plasma [76,77], serum [18,24,42,75,78], urine [74,75,79], pleural effusion [80], or hair [24,73], and recently in bronchoalveolar lavage fluid (BALF) for the first time [75]. Table 1 has a collection of the typical concentrations in tissues and biofluids of LC patients and HC that can be found in the literature.…”

Section: Metal Dyshomeostasis In Lung Cancer: Biofluids and Tissuesmentioning

confidence: 99%

The Metallome of Lung Cancer and its Potential Use as Biomarker

Callejón‐Leblic

Arias-Borrego

Pereira‐Vega

et al. 2019

IJMS

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Carcinogenesis is a very complex process in which metals have been found to be critically involved. In this sense, a disturbed redox status and metal dyshomeostasis take place during the onset and progression of cancer, and it is well-known that trace elements participate in the activation or inhibition of enzymatic reactions and metalloproteins, in which they usually participate as cofactors. Until now, the role of metals in cancer have been studied as an effect, establishing that cancer onset and progression affects the disturbance of the natural chemical form of the essential elements in the metabolism. However, it has also been studied as a cause, giving insights related to the high exposure of metals giving a place to the carcinogenic process. On the other hand, the chemical species of the metal or metallobiomolecule is very important, since it finally affects the biological activity or the toxicological potential of the element and their mobility across different biological compartments. Moreover, the importance of metal homeostasis and metals interactions in biology has also been demonstrated, and the ratios between some elements were found to be different in cancer patients; however, the interplay of elements is rarely reported. This review focuses on the critical role of metals in lung cancer, which is one of the most insidious forms of cancer, with special attention to the analytical approaches and pitfalls to extract metals and their species from tissues and biofluids, determining the ratios of metals, obtaining classification profiles, and finally defining the metallome of lung cancer.

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Section: Metal Dyshomeostasis In Lung Cancer: Biofluids and Tissuesmentioning

confidence: 99%

The Metallome of Lung Cancer and its Potential Use as Biomarker

Callejón‐Leblic

Arias-Borrego

Pereira‐Vega

et al. 2019

IJMS

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“…The glutathione S transferase (GST) gene was reported by 3 papers (Jin et al, 2011;Reszka et al, 2007;Reszka et al, 2005). The detoxifying enzyme GST metabolises tobacco smoke derived compounds; zinc deficiency therefore can increase the risk of mutations occurring and can decrease the activity of the antioxidant GST enzyme increasing the risk of some cancers including lung cancer.…”

Section: Factors Affecting Zinc Bioavailabilitymentioning

confidence: 99%

“…The gene CYP1A1 was also investigated by Jin et al (2011). The CYP1A1 gene has a polymorphism at exon 7 where a new Mspl restriction site is introduced.…”

Section: Factors Affecting Zinc Bioavailabilitymentioning

confidence: 99%

EURRECA—Estimating Zinc Requirements for Deriving Dietary Reference Values

Hurst

Collings

Harvey

et al. 2013

Critical Reviews in Food Science and Nutrition

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Zinc was selected as a priority micronutrient for EURRECA, because there is significant heterogeneity in the Dietary Reference Values (DRVs) across Europe. In addition, the prevalence of inadequate zinc intakes was thought to be high among all population groups worldwide, and the public health concern is considerable. In accordance with the EURRECA consortium principles and protocols, a series of literature reviews were undertaken in order to develop best practice guidelines for assessing dietary zinc intake and zinc status. These were incorporated into subsequent literature search strategies and protocols for studies investigating the relationships between zinc intake, status and health, as well as studies relating to the factorial approach (including bioavailability) for setting dietary recommendations. EMBASE (Ovid), Cochrane Library CENTRAL and MEDLINE (Ovid) databases were searched for studies published up to February 2010 and collated into a series of Endnote databases that are available for the use of future DRV panels. Meta-analyses of data extracted from these publications were performed where possible in order to address specific questions relating to factors affecting dietary recommendations. This review has highlighted the need for more high quality studies to address gaps in current knowledge, in particular the continued search for a reliable biomarker of zinc status and the influence of genetic polymorphisms on individual dietary requirements. In addition, there is a need to further develop models of the effect of dietary inhibitors of zinc absorption and their impact on population dietary zinc requirements.

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“…Many authors have reported concentrations of essential and nonessential elements in human biological samples from patients with lung cancer, such as serum 21,[23][24][25] , plasma 26,27 , urine 28,29 , pleural efussion 22 or hair 24,30 . In addition, there are several papers describing the analysis of metals in bronchoalveolar lavage fluid 31,32 , but they are not related with lung cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Metal dyshomeostasis based biomarkers of lung cancer using human biofluids

et al. 2018

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Lung cancer (LC) is one of the most common causes of cancer-related deaths in the world and it is well known that trace elements play important roles in the carcinogenic process activating and inhibiting enzymatic reactions and metalloproteins, in which they usually participate as cofactors. A cross-sectional study was conducted on 48 lung cancer patients and 39 controls (56 men and 31 women), aged 44-76 years between March 2011 and June 2012. Eleven elements have been included in the study: V, Cr, Mn, Fe, Co, Cu, Zn, Se, Mo, Cd, and Pb, some of them considered toxic (V, Cd, Cr and Pb), while others are essential (Co, Mo, Se, Fe and Zn), and they have been analyzed by ICP-QQQ-MS in serum, urine and for the first time in bronchoalveolar lavage fluid (BALF). In order to understand the involvement of metals in this process, an analytical metallomic approach based on non-denaturing precipitation of proteins (NDPP) has been optimized for the fractionation of high molecular mass (HMM) and low molecular mass (LMM) metal species, in order to distinguish between metal species that affect the biological activity and toxicological potential of the elements. In this work, the NDPP followed by the analysis of metals by ICP-QQQ-MS has been applied for the first time to serum, urine and BALF samples from lung cancer patients and controls in order to get metal-size molecule profiles (MSMP), which can be used as metal-based biomarkers of altered metabolic processes such as oxidative stress and homeostasis. In this sense, we have demonstrated that several metals are good biomarkers when they are related to labile complexes, complexed with low molecular mass ligands, or in the form of metalloproteins (i.e. V and Cr in HMM and Cu in LMM), which has been described for the first time. On the other hand, metal dyshomeostasis biomarkers are proposed using metal ratios and correlations. Finally, the ratios between elements were shown to be important biomarkers for lung cancer in serum (V/Mn, V/Pb, V/Zn, Cr/Pb), urine (Cr/Cd, Mn/Cd, V/Cd, Co/Cd, Cd/Pb) and BALF (V/Cu), which reflects the dyshomeostasis of metals in lung cancer. In this sense, several metals are correlated to others suggesting also the existence of an interconnected homeostasis in lung cancer.

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Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case–control study in China

Cited by 40 publications

References 25 publications

The Metallome of Lung Cancer and its Potential Use as Biomarker

The Metallome of Lung Cancer and its Potential Use as Biomarker

EURRECA—Estimating Zinc Requirements for Deriving Dietary Reference Values

Metal dyshomeostasis based biomarkers of lung cancer using human biofluids

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