Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation

Berardesca, Enzo; Cameli, Norma; Cavallotti, Claudia; Levy, Jean Luc; Pierard, Gérald; Ambrosi, Gianfranco de Paoli

doi:10.1111/j.1473-2165.2008.00355.x

Cited by 44 publications

(27 citation statements)

References 13 publications

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“…Q . amara extract (Ferrari and Diehl, ), niacinamide (Draelos et al , ), silymarin (Berardesca et al , ), and oral nicotinamide/zinc/copper/folate supplementation (Niren and Torok, ) improved papule and pustule counts. Q .…”

Section: Resultsmentioning

confidence: 92%

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Phytochemical and Botanical Therapies for Rosacea: A Systematic Review

et al. 2015

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Botanical and cosmeceutical therapies are commonly used to treat symptoms of rosacea such as facial erythema, papules/pustule counts, and telangiectasia. These products may contain plant extracts, phytochemicals, and herbal formulations. The objective of this study was to review clinical studies evaluating the use of botanical agents for the treatment of rosacea. MEDLINE and Embase databases were searched for clinical studies evaluating botanical therapies for rosacea. Major results were summarized, and study methodology was analyzed. Several botanical therapies may be promising for rosacea symptoms, but few studies are methodologically rigorous. Several plant extract and phytochemicals effectively improved facial erythema and papule/pustule counts caused by rosacea. Many studies are not methodologically rigorous. Further research is critical, as many botanicals have been evaluated in only one study. Botanical agents may reduce facial erythema and effectively improve papule/pustule counts associated with rosacea. Although promising, further research in the area is imperative.

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Section: Resultsmentioning

confidence: 92%

“…Q. amara (Ferrari and Diehl, ) extract, lichochalcone moisturizer (Weber et al , ; Broniarczyk‐Dyla et al , ), silymarin extract (Berardesca et al , ), C . indicum extract, kinetin cream, nicotinamide/zinc/copper/folate oral tablet, and Chibixiao recipe improved facial erythema.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical and Botanical Therapies for Rosacea: A Systematic Review

et al. 2015

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“…At each visit, instrumental evaluations of erythema and stratum corneum hydration were performed on the forehead, cheeks, and chin by assessing the erythema index (Mexameter ® ; C+K electronic, Cologne, Germany) and skin capacitance (Corneometer ® CM 825; C+K electronic), respectively. Both the Mexameter ® and Corneometer ® are noninvasive devices widely used for assessing skin conditions and the effects of topically applied products 12–14 . Moreover, flushing, erythema, edema, itching, burning and stinging were evaluated on a four‐point scale, where 0 = none, 1 = mild, 2 = moderate and 3 = severe.…”

Section: Methodsmentioning

confidence: 99%

Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea

Berardesca

Iorizzo

Abril

et al. 2012

J of Cosmetic Dermatology

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SummaryBackgroundRosacea is a chronic inflammatory skin disease affecting mostly facial skin. Its origin is multifactorial. Important steps in its treatment are avoidance of any triggering factor and control of skin inflammation.AimTo assess the benefit of topical applications of a new product (P-3075).Patients/MethodsA randomized, multicenter, double-blind, placebo-controlled, parallel-group, pilot study was carried out to evaluate the efficacy and tolerability of a cream (P-3075) based on 5% potassium azeloyl diglycinate (PAD, Azeloglicina®) and 1% hydroxypropyl chitosan (HPCH). Forty-two patients (rosacea stages I and II) were enrolled and randomized, 28 in the P-3075 group and 14 in the placebo group. They were asked to apply the cream twice daily for 4 weeks. The main assessments were the objective quantification of erythema and skin hydration using the Mexameter® and Corneometer® devices, respectively. Clinical signs and symptoms were evaluated on a four-point scale.ResultsThe P-3075 cream applied for 28 days was effective in skin protection by reducing erythema, evaluated both instrumentally and clinically. In addition, the clinical assessments of other symptoms such as flushing, stinging, and burning supported the beneficial effect of the P-3075 cream.ConclusionsThe anti-inflammatory and moisturizing effects of potassium azeloyl diglycinate combined with the protective properties of HPCH allow the new product to be a good candidate for controlling signs and symptoms of rosacea.

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“…Human combination studies with four peeling sessions using pyruvic acid and MSM once every two weeks improved the degree of pigmentation of melisma, skin elasticity, and the degree of wrinkling [178]. A combination treatment of silymarin and MSM proved useful in managing rosacea symptoms [179]. A case study of a 44 year old man with severe X-linked type ichthyosis showed improvement of symptoms after four weeks of topical moisturizer containing amino acids, vitamins, antioxidants, and MSM [180].…”

Section: Common Usesmentioning

confidence: 99%

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

Benjamin²,

2017

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Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. It has been well-investigated in animal models, as well as in human clinical trials and experiments. A variety of health-specific outcome measures are improved with MSM supplementation, including inflammation, joint/muscle pain, oxidative stress, and antioxidant capacity. Initial evidence is available regarding the dose of MSM needed to provide benefit, although additional work is underway to determine the precise dose and time course of treatment needed to provide optimal benefits. As a Generally Recognized As Safe (GRAS) approved substance, MSM is well-tolerated by most individuals at dosages of up to four grams daily, with few known and mild side effects. This review provides an overview of MSM, with details regarding its common uses and applications as a dietary supplement, as well as its safety for consumption.

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Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation

Cited by 44 publications

References 13 publications

Phytochemical and Botanical Therapies for Rosacea: A Systematic Review

Phytochemical and Botanical Therapies for Rosacea: A Systematic Review

Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

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