2019
DOI: 10.1101/661272
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Combined EGFR and ROCK inhibition in TNBC leads to cell death via impaired autophagic flux

Abstract: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell death, however, the underlying mechanisms remain unclear. To investigate this, here we applied a mass spectrometry-based proteomic approach to identify proteins altered upon single and combination treatments. Our proteomic data revealed autophagy as the major molecular mechanism implicated in the … Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 53 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?