Combined endocrine cell carcinoma and adenocarcinoma of the gallbladder

Fish, D.E.; Al-Izzi, Mohanad Hasan Mahmood; George, P.S.; Whitaker, B.

doi:10.1111/j.1365-2559.1990.tb00772.x

Cited by 18 publications

(10 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, neuroendocrine tumors are rare, representing only about 0.5% of all gallbladder tumors 1 . Mixed tumors are even rarer, with very few cases reported in the literature 3,15,16 …”

Section: Discussionmentioning

confidence: 99%

“…1 Mixed tumors are even rarer, with very few cases reported in the literature. 3,15,16 Of the rare cases of mixed tumors described to date, epithelial elements are usually of the adenocarcinoma (tubular and mucin producing), 3 adenosquamous, 2 signet ring 3,15,17 and undifferentiated carcinoma 3,18 types, while the Immunoreactivity of the adenocarcinoma and neuroendocrine components were compared. Note the shared reactivity to antibodies directed against biliary markers (K7, K19) and the epithelial cell adhesion molecule (EpCAM) amongst both morphological components, as well as the mild-to moderate common immunoreactivity to lineage specific markers (K20, CD56 and synaptophysin (Syn)).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor?

Mondolfi

Slova

Fan

et al. 2011

Pathology International

View full text Add to dashboard Cite

A 48 year-old African American woman presented to her physician complaining of a rapidly evolving epigastric and right upper quadrant abdominal pain. A PET-CT of the abdomen and pelvis demonstrated hypermetabolic, polypoid masses within the gallbladder and several tumors in the left lobe of the liver for which she underwent diagnostic laparoscopy. The gallbladder revealed a 3.5 × 3.3 × 2.4 tan-brown exophytic mass located at the fundus and growing into the lumen with multiple contiguous papillary projections arising from the mucosal surface. A concurrent large cell neuroendocrine carcinoma and papillary adenocarcinoma of the gallbladder was revealed histologically. There was shared reactivity to antibodies directed against the distinct antigens for each morphological component with transitional tumor cells (of both histological components) located at the areas where the two tumor types merged, revealing common immunoreactivity for carcinoembryonic antigen, cancer antigen 19-9, keratin 19, c-kit (cluster of differentiation protein 117 (CD117)) and epithelial cell adhesion molecule. Ultrastructurally, individual cells were demonstrated to have overlapping features of neuroendocrine and glandular differentiation. The aforementioned histological, ultrastructural and immunohistochemical profile is strongly suggestive of a biphenotypic stem/progenitor cell tumor of the gallbladder.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor?

Mondolfi

Slova

Fan

et al. 2011

Pathology International

View full text Add to dashboard Cite

show abstract

“…12,14,19,23,32 The composite or mixed tumors arise from a common precursor cell and are characterized by an intricate mixture of both elements. In collision tumors, the adenocarcinoma and neuroendocrine carcinoma arise from two different precursor cells and differentiate simultaneously without mixture of cell components.…”

Section: Discussionmentioning

confidence: 99%

Hepatobiliary Neuroendocrine Carcinoma in Cats: A Clinicopathologic, Immunohistochemical, and Ultrastructural Study of 17 Cases

et al. 2005

View full text Add to dashboard Cite

Hepatobiliary neuroendocrine carcinoma was diagnosed in 17 cats in a period of 10 years. Seven tumors were of intrahepatic origin, one of which was a composite containing components of epithelial and neuroendocrine carcinoma. Nine tumors were of extrahepatic origin, and one tumor was located in the gall-bladder. The cats were adult and geriatric, and the male : female ratio varied according to tumor group. Hepatomegaly, anorexia, weight loss, and vomiting were the most common clinical signs observed in the cats with hepatic neuroendocrine carcinoma. The cats with extrahepatic neuroendocrine carcinoma showed these signs plus icterus (5/9) and high concentrations of hepatic enzymes. Histologically, the hepatic neuroendocrine carcinomas had two patterns, one with acinar structures separated by vascular stroma lined by cuboidal or columnar cells and the other solid with groups of anaplastic cells separated by vascular stroma. The composite tumor consisted of both bile duct carcinoma and neuroendocrine carcinoma. The extrahepatic neuroendocrine carcinomas and the gallbladder neuroendocrine carcinoma were characterized by solid sheets or groups of round to oval cells with vascular or fibrovascular stroma. Immunohistochemical examination of 10 of the neuroendocrine carcinomas revealed that all 10 stained with neuron-specific enolase; one bile duct carcinoma and the gallbladder carcinoma stained with chromogranin; four of five bile duct carcinomas and the gall bladder carcinoma stained with synaptophysin; and one bile duct carcinoma stained with gastrin. One cat with hepatic carcinoma had duodenal ulcer; in this cat, ultrastructural studies showed neurosecretory granules leading to the diagnosis of Zollinger-Ellison syndrome. In four cats in which necropsy was permitted, carcinomatosis (4/4), lymph nodes (4/4), lungs (2/4), and intestines (1/4) were the metastatic sites. Fourteen of the 17 cats were euthanatized during or immediately after surgery.

show abstract

“…The existence of a common precursor cell for endocrine cells and nonendocrine epithelial cells in the bile duct mucosa has been proposed regarding the histogenesis of small-cell carcinoma [9]. In composite tumors, two components may originate in a common precursor cell, and thereafter, the tumor simultaneously develops in two different directions [1].…”

Section: Discussionmentioning

confidence: 99%

Small-cell carcinoma of the extrahepatic bile duct: a case report and review of the literature

Hosonuma¹,

Sato

Honma³

et al. 2007

Hepatol Int

View full text Add to dashboard Cite

A small-cell carcinoma of the extrahepatic bile duct in a 69-year-old woman is herein reported. A tumor measuring approximately 3 cm in diameter was located at the confluence of the common bile duct, cystic duct, and common hepatic duct. Histopathologically, the tumor was small-cell neuroendocrine carcinoma without any gland formation or differentiation to squamous cell carcinoma. Tumor cells were immunoreactive for epithelial markers such as epithelial membrane antigen and cytokeratin and for the neuroendocrine markers such as neuron-specific enolase, chromogranin A, and synaptophysin. Although the carcinomas in more than half of the reported cases have been reported to be associated with well-to-moderately differentiated squamous or glandular components, seven cases, including our case, showed the carcinomas without squamous or glandular components. According to the review of 16 previously reported cases and our case of small-cell carcinoma of the extrahepatic bile ducts, there is no significant difference in the clinicopathological findings, namely, age, sex, site of carcinoma, and prognosis between the cases with or without squamous or glandular components. No CD34-positive multipotent adult progenitor cells, which might be the origin of the small-cell carcinoma, were detected in the bile duct epithelium in our case.

show abstract

Combined endocrine cell carcinoma and adenocarcinoma of the gallbladder

Cited by 18 publications

References 2 publications

Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor?

Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor?

Hepatobiliary Neuroendocrine Carcinoma in Cats: A Clinicopathologic, Immunohistochemical, and Ultrastructural Study of 17 Cases

Small-cell carcinoma of the extrahepatic bile duct: a case report and review of the literature

Contact Info

Product

Resources

About