Combined ethanol extract of Funtumia africana and Abutilon mauritianium leaves improves the lipid profile and kidney function indices of benign prostatic hyperplasia in rats

Uroko, Robert Ikechukwu; Chukwu,; Egba, Simeon Ikechukwu; Adamude, Fatima Amin; Ajuzie, Joy C.

doi:10.17306/j.afs.0819

Cited by 2 publications

(2 citation statements)

References 22 publications

(32 reference statements)

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“…Similarly, Uroko et al . [ 39 ] reported that a mixture of ethanol extracts of Funtumia africana and Abutilon mauritianium leaves was significant in improving of BPH, including the protection against kidney damage, in BPH-induced rats. In fact, several studies have been reported on the component analysis of CF and SF [ 40 41 ], and previous studies demonstrated that loganin, a representative bioactive substance of CF, has improvement effects on acute kidney injury and diabetic neuropathy by alleviating oxidative stress and inflammation [ 42 43 ].…”

Section: Discussionmentioning

confidence: 99%

Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor

Hwangbo

Kim

et al. 2023

Nutr Res Pract

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BACKGROUND/OBJECTIVES Benign prostatic hyperplasia (BPH) characterized by an enlarged prostate gland is common in elderly men. Corni Fructus (CF) and Schisandrae Fructus (SF) are known to have various pharmacological effects, including antioxidant and anti-inflammatory activities. In this study, we evaluated the inhibitory efficacy of CF, SF, and their mixture (MIX) on the development of BPH using an in vivo model of testosterone-induced BPH. MATERIALS/METHODS Six-week-old male Sprague-Dawley rats were randomly divided into seven groups. To induce BPH, testosterone propionate (TP) was injected to rats except for those in the control group. Finasteride, saw palmetto (SP), CF, SF, and MIX were orally administered along with TP injection. At the end of treatment, histological changes in the prostate and the level of various biomarkers related to BPH were evaluated. RESULTS Our results showed that BPH induced by TP led to prostate weight and histological changes. Treatment with MIX effectively improved TP-induced BPH by reducing prostate index, lumen area, epithelial thickness, and expression of BPH biomarkers such as 5α-reductase type 2, prostate-specific antigen, androgen receptor, and proliferating cell nuclear antigen compared to treatment with CF or SF alone. Moreover, MIX further reduced levels of elevated serum testosterone, dihydrotestosterone, and prostate-specific antigen in BPH compared to the SP, a positive control. BPH was also improved more by MIX than by CF or SF alone. CONCLUSIONS Based on the results, MIX is a potential natural therapeutic candidate for BPH by regulating 5α-reductase and AR signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor

Hwangbo

Kim

et al. 2023

Nutr Res Pract

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“…The leaf extracts also showed positive impact on rat prostatic hyperplasia indicators such as levels of testosterone, dihydrotestosterone, and estradiol and also showed bactericidal activity against strains of methicillin resistant Staphylococcus aureus [21,22] . The observed moderation of triacylglycerol and high-density lipoproteins suggest that the combined F. africana extract possesses antilipidaemic properties [23] . Therefore, there has been escalating medicinal interest in F. africana.…”

Section: Current Researchmentioning

confidence: 96%

A mini-review of pharmacological and economical values of Funtumia africana

Oyaseiye¹,

Tautua²,

Songca³

2022

J Pharmacogn Phytochem

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Funtumia africana belongs to the family Apocynaceae. It is a fast growing tree found in green forests and forest reserves in West Africa. The plant has a long history of use in traditional medicine to treat and manage various diseases such as diabetes, cancer, burns, amoebic dysentery, urinary incontinence, bacterial infections and malaria. It is used economically for the production of furniture, match sticks and firewood. This review paper presents the botanical description, pharmacological uses and economic importance of F. africana.

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Combined ethanol extract of Funtumia africana and Abutilon mauritianium leaves improves the lipid profile and kidney function indices of benign prostatic hyperplasia in rats

Cited by 2 publications

References 22 publications

Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor

Mixture of Corni Fructus and Schisandrae Fructus improves testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor

A mini-review of pharmacological and economical values of Funtumia africana

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