Combined Evaluation of Arterial Stiffness and Blood Pressure Promotes Risk Stratification of Peripheral Arterial Disease

Wu, Zhiyuan; Jiang, Yue; Zhu, Qian; Zhang, Haiping; Li, Zhiwei; Wang, Jinqi; Pan, Huiying; Guo, Zheng; Zheng, Yulu; Li, Xia; Tao, Lixin; Gao, Bo; Guo, Xiuhua

doi:10.1016/j.jacasi.2023.02.001

Cited by 2 publications

(3 citation statements)

References 54 publications

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“…Previous studies have consistently reported that PWV is closely influenced by major risk factors for CV events, including abnormal lipid phenotype, insulin resistance, and blood pressure. Our study also showed that patients with high PWV had more traditional CV risk factors and comorbidities than those with low PWV ( 26 , 34 , 35 ). Second, arterial stiffness is associated with endothelial dysfunction, platelet activation, and plaque vulnerability; the latter are significantly associated with the development and prognosis of CAD ( 36 , 37 ).…”

Section: Discussionsupporting

confidence: 65%

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Long-term prognostic implications of brachial-ankle pulse wave velocity in patients undergoing percutaneous coronary intervention

Kim,

Ahn,

Shin

et al. 2024

Front. Med.

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ObjectiveThe long-term clinical effect of arterial stiffness in high-risk disease entities remains unclear. The prognostic implications of brachial-ankle pulse wave velocity (baPWV) were assessed using a real-world registry that included patients who underwent percutaneous coronary intervention (PCI).MethodsArterial stiffness was measured using baPWV before discharge. The primary outcome was net adverse clinical events (NACE), defined as a composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or major bleeding. Secondary outcomes included major adverse cardiac and cerebrovascular events (MACCE: a composite of all-cause death, non-fatal myocardial infarction, or non-fatal stroke), and major bleeding. The outcomes were assessed over a 4-year period.ResultsPatients (n = 3,930) were stratified into high- and low-baPWV groups based on a baPWV cut-off of 1891 cm/s determined through time-dependent receiver operating characteristic curve analysis. baPWV was linearly correlated with 4-year post-PCI clinical events. The high baPWV group had a greater cumulative incidence of NACE, MACCE, and major bleeding. According to multivariable analysis, the high baPWV groups had a significantly greater risk of 4-year NACE (adjusted hazard ratio [HRadj]: 1.44; 95% confidence interval [CI]: 1.12–1.85; p = 0.004), MACCE (HRadj: 1.40; 95% CI: 1.07–1.83; p = 0.015), and major bleeding (HRadj: 1.94; 95% CI: 1.15–3.25; p = 0.012).ConclusionIn PCI-treated patients, baPWV was significantly associated with long-term clinical outcomes, including ischemic and bleeding events, indicating its value for identifying high-risk phenotypes.

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Section: Discussionsupporting

confidence: 65%

“…Youden’s index was used to calculate the optimal cut-off value. Additionally, we classified baPWV into three categories based on a previous study for sensitivity analysis: <1400, ≥1400 & <1800, and ≥1800 cm/s ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

Long-term prognostic implications of brachial-ankle pulse wave velocity in patients undergoing percutaneous coronary intervention

Kim,

Ahn,

Shin

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

“…This elevated risk of bypass/revascularization is probably a consequence of the higher incidence of ischemic heart disease in SARS-CoV-2 positive individuals. Other authors suggest that the increased occurrence of peripheral artery disease could be due to worsening arterial stiffness following SARS-CoV-2 infection [25] , [26] .…”

Section: Discussionmentioning

confidence: 99%

Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection

Tintore,

Cuartero,

Camps-Vilaró

et al. 2024

Computational and Structural Biotechnology Journal

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Combined Evaluation of Arterial Stiffness and Blood Pressure Promotes Risk Stratification of Peripheral Arterial Disease

Cited by 2 publications

References 54 publications

Long-term prognostic implications of brachial-ankle pulse wave velocity in patients undergoing percutaneous coronary intervention

Long-term prognostic implications of brachial-ankle pulse wave velocity in patients undergoing percutaneous coronary intervention

Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection

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