Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats

Zhang, Haiyang; Jiao, Wenjing; Cui, Hailin; Sun, Qingping; Fan, Honggang

doi:10.1016/j.jhazmat.2021.125179

Cited by 64 publications

(32 citation statements)

References 63 publications

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“…AlNPs-intoxicated rats, re ecting in ammatory response which may contribute to development of neurodegenerative de cits (Win-Shwe and Fujimaki 2011;Guo et al 2018). Similar to our results, AlNP increased the levels of proin ammatory cytokines such as IL-1β, IL-6 and TNF-α in brain of rats(Arslanbaş and Coşar 2019;Liu et al 2020a;Zhang et al 2021a) and in vitro in astrocytes of neonatal rats(Dong et al 2019). Compelling evidence has suggested activation of NF-κB as a major pathway of aluminum induced neuroin ammation(Zhang et al 2018).…”

supporting

confidence: 89%

“…They penetrate the blood-brain barrier (BBB) easily owing to their small size (De et al 2020) and their effect on BBB permeability through downregulation of the tight junction protein expression such as occludin and claudin-5 (Chen et al 2008). The penetrating AlNPs were reported to accumulate in the hippocampus, olfactory bulb, cerebral cortex, and striatum causing learning and memory dysfunction and depression-like behavior (Shah et al 2015;Zhang et al 2021a). Furthermore, AlNPs were recognized as a major contributor to many neurodegenerative disorders such as Alzheimer's and Parkinson's diseases (Zhang et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Nanoparticle-mediated oxidative injury has been shown to orchestrate a series of in ammatory responses (Manke et al 2013) with release of pro-in ammatory mediators via NF-κB/MAPK activation ( Zhang et al 2021a). The produced neuroin ammation has been linked to Alzheimer disease and other neurodegenerative disorders (Win-Shwe and Fujimaki 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Arslanbaş and Coşar 2019;De et al 2020;Zhang et al 2021a). In addition, brain oxidative stress was reported in rats received AlNPs intraperitoneal(Li et al 2009; Morsy et al 2016), intravenous(Mrad et al 2017), or via intranasal instillation(Ji et al 2011).…”

mentioning

confidence: 99%

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Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Abou‐Zeid

Elkhadrawey

Anis

et al. 2021

Preprint

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Alumina nanoparticles (AlNPs) are widely used causing neurobehavioral impairment in intoxicated animals and human. Sesamol (SML) emerged as a natural phytochemical with potent antioxidant and anti-inflammatory properties. However, no study has directly tested the potential of SML to protect against AlNPs induced detrimental effects on the brain. AlNPs (100 mg/kg) were orally administered to `rats by gavage with or without oral sesamol (100 mg/kg) for 28 days. In AlNPs-intoxicated group, brain AChE activity was elevated. The concentrations of MDA and 8-OHdG were increased suggesting lipid peroxidation and oxidative DNA damage. GSH depletion with inhibited activities of CAT and SOD were demonstrated. Serum levels of IL-1β and IL-6 were elevated. The expressions of GST, TNF-α and caspase-3 genes in brain were upregulated. Histopathologically, AlNPs induced hemorrhages, edema, neuronal necrosis and/ or apoptosis in medulla oblongata. The cerebellum showed loss of Purkinje cells and the cerebrum showed perivascular edema, neuronal degeneration, necrosis, and neuronal apoptosis. However, concomitant administration of SML with AlNPs significantly ameliorated the toxic effects on the brain, reflecting antioxidant, anti-inflammatory and anti-apoptotic effects of SML. Considering these results, sesamol could be promising phytochemical with neuroprotective activity against AlNPs-induced neurotoxicity.

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supporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Abou‐Zeid

Elkhadrawey

Anis

et al. 2021

Preprint

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“…Oral treatment of rats with AlNPs (<50 nm) at 50 mg/kg, once daily for 90 days resulted in hippocampal oxidative stress associated with neuronal ferroptosis. Moreover, significant increases in the hippocampus content of IFN-γ, TNF-α, IL-1β, and IL-6 were recorded (Zhang et al, 2021).…”

Section: Genotoxicity 51 In-vitromentioning

confidence: 97%

Potential Toxic Effects of Aluminum Nanoparticles: An overview

Elkhadrawy¹,

Abou-Zeid²,

El-Borai³

et al. 2021

Journal of Current Veterinary Research

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Alumina (aluminum oxide) nanoparticles (AlNPs) have been categorized among the most important nano-metals, with wide applications in many fields as in food, agriculture, industry, engineering, pharmacy, medicine and others. The extensive use of AlNPs results in a massive release of them into the environment resulting in potential adverse impacts on animals and human health. Toxicokinetic studies demonstrated the rapid absorption and the systemic distribution of AlNPs to different organs. AlNPs mainly induced their toxic damage by induction of oxidative stress and mitochondrial dysfunction. Cellular accumulation of AlNPs resulted in interaction with cell components and binding with proteins and genetic materials (DNA and RNA) with producing other different chemical compounds resulting in cellular oxidative damage. Also, AlNPs induced cell death by disrupting the integrity of the mitochondrial membrane, depleting the mitochondrial thiols, activating apoptotic caspases (9 and 3) and generating more ROS. Previous in vivo and in vitro studies revealed hepato-, nephro-, myocardial, reproductive and neuro-toxic effects of AlNPs. Moreover, AlNPs exert inflammatory, apoptotic and geno-toxic effects. The aim here is to spot on previous studies demonstrating the toxic effects of AlNPs.

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Fe₃O₄‐Incorporated Metal‐Organic Framework for Chemo/Ferroptosis Synergistic Anti‐Tumor via the Enhanced Chemodynamic Therapy

Xu,

Wang,

Xiong

et al. 2024

Adv Healthcare Materials

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Metal‐organic framework (MOF)‐based drug delivery nanomaterials for cancer therapy have attracted increasing attention in recent years. Here, we propose an enhanced chemodynamic anti‐tumor therapy strategy by promoting the Fenton reaction by using core‐shell zeolitic imidazolate framework‐8 (ZIF‐8)@Fe3O4 as a therapeutic platform. Carboxymethyl cellulose (CMC) was used as a stabilizer of Fe3O4, which then decorated on the surface of ZIF‐8 via the electrostatic interaction and served as an efficient Fenton reaction trigger. Meanwhile, the pH‐responsive ZIF‐8 scaffold acted as a container to encapsulate the chemotherapeutic drug doxorubicin (DOX). The obtained DOX‐ZIF‐8@Fe3O4/CMC nanoparticles concomitantly accelerated DOX release and generated more hydroxyl radicals by targeting the lysosomes in cancer cells. In vitro and in vivo studies verify that the DZFC nanoparticles trigger GPX4‐dependent ferroptosis via the activation of the c‐Jun N‐terminal kinases (JNK) signaling pathway, following to achieve the chemo/ferroptosis synergistic anti‐tumor efficacy. No marked toxic effects were detected during DZFC treatment in a tumor‐bearing mouse model. This composite nanoparticle remarkably suppressed the tumor growth with minimized systemic toxicity, opening new horizons for the next generation of theragnostic nanomedicines.This article is protected by copyright. All rights reserved

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Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats

Cited by 64 publications

References 63 publications

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Potential Toxic Effects of Aluminum Nanoparticles: An overview

Fe₃O₄‐Incorporated Metal‐Organic Framework for Chemo/Ferroptosis Synergistic Anti‐Tumor via the Enhanced Chemodynamic Therapy

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Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats

Cited by 64 publications

References 63 publications

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Potential Toxic Effects of Aluminum Nanoparticles: An overview

Fe3O4‐Incorporated Metal‐Organic Framework for Chemo/Ferroptosis Synergistic Anti‐Tumor via the Enhanced Chemodynamic Therapy

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Product

Resources

About

Fe₃O₄‐Incorporated Metal‐Organic Framework for Chemo/Ferroptosis Synergistic Anti‐Tumor via the Enhanced Chemodynamic Therapy