Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus)

Zheng, Qingzhi; Cui, Lihua; Liao, Hongping; Junaid, Muhammad; Li, Zhen; Liu, Shulin; Gao, Dandan; Zheng, Yufeng; Lu, Shaoyong; Qiu, Jian; Wang, Jun

doi:10.1016/j.scitotenv.2023.164319

Cited by 24 publications

(4 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SOD, CAT, GSH-Px, T-AOC, and MDA are important indicators of antioxidant function. SOD and CAT are able to scavenge free radicals to reduce the damage caused by oxidative stress to the intestinal mucosa, which plays an important role in intestinal defense and repair ( 19 ); GSH-Px mirrors the body’s ability to scavenge free radicals, which protects the animal from damage caused by lipid peroxides ( 20 ); T-AOC is a comprehensive indicator of antioxidant function, reflecting the ability to compensate for external stimuli and the state of free radical metabolism ( 19 ); and MDA content represents the degree of lipid peroxidation and indirectly the degree of cellular damage ( 21 ). The present study showed that the SOD, CAT, GSH-Px, and T-AOC activities in wild M. albus were significantly higher, while the MDA level was significantly lower compared with the cultured ones, indicating that the antioxidant capacity of wild M. albus is stronger than that of cultured M. albus .…”

Section: Discussionmentioning

confidence: 99%

Comparative studies on the intestinal health of wild and cultured ricefield eel (Monopterus albus)

Yang,

Yuan,

Rahman

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Fish intestinal health under intensive aquaculture mode plays an important role in growth, development, and immune function. The present study was aimed to systematically investigate the differences of intestinal health between wild and cultured Monopterus albus by biochemical parameters, histomorphology, and molecular biology. A total of 15 healthy M. albus per group, with an average body weight of 45 g, were sampled to analyze intestinal health parameters. Compared with wild fish, the cultured M. albus in the foregut had lower trypsin, lipase, SOD, CAT, T-AOC, and GSH-Px activities (P < 0.05) and higher amylase activity and MDA content (P < 0.05). The villus circumference and goblet cells in the cultured group were significantly lower than those in the wild group (P < 0.05). In addition, the cultured fish showed lower relative expression levels of occludin, zo-1, zo-2, claudin-12, claudin-15, mucin5, mucin15, lysozyme, complement 3, il-10, tgf-β1, tgf-β2, and tgf-β3 (P < 0.05) and higher il-1β, il-6, il-8, tnf-a, and ifnγ mRNA expressions than those of wild fish (P < 0.05). In terms of gut microbiota, the cultured group at the phylum level displayed higher percentages of Chlamydiae and Spirochaetes and lower percentages of Firmicutes, Bacteroidetes, Actinobacteria, Cyanobacteria, and Verrucomicrobia compared to the wild group (P < 0.05). At the genus level, higher abundances of Pseudomonadaceae_Pseudomonas and Spironema and lower abundances of Lactococcus and Cetobacterium were observed in the cultured group than in the wild group (P < 0.05). To our knowledge, this is the first investigation of the intestinal health status between wild and cultured M. albus in terms of biochemistry, histology, and molecular biology levels. Overall, the present study showed significant differences in intestinal health between wild and cultured M. albus and the main manifestations that wild M. albus had higher intestinal digestion, antioxidant capacity, and intestinal barrier functions than cultured M. albus. These results would provide theoretical basis for the subsequent upgrading of healthy aquaculture technology and nutrient regulation of intestinal health of cultured M. albus.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative studies on the intestinal health of wild and cultured ricefield eel (Monopterus albus)

Yang,

Yuan,

Rahman

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The structural integrity of the intestinal epithelial cells is critical for the maintenance of intestinal barrier function, which can be affected by various exogenous factors . The abrasion of intestinal villi cells was observed in fish exposed to individual PSNP treatment . Some studies have already reported that enterocyte sloughing, cellular infiltration, submucosal edema, and abrasion of the intestinal villi became more severe after exposure to DEHP. , MUC1 and MUC2 are intestinal-type mucins that play vital roles in the maintenance of intestinal epithelial barrier function.…”

Section: Discussionmentioning

confidence: 99%

AQP1 Deficiency Drives Phthalate-Induced Epithelial Barrier Disruption through Intestinal Inflammation

Zhao,

Hu,

Lou

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer to enhance the plasticity and durability of agricultural products, which pose adverse effects to human health and the environment. Aquaporin 1 (AQP1) is a main water transport channel protein and is involved in the maintenance of intestinal integrity. However, the impact of DEHP exposure on gut health and its potential mechanisms remain elusive. Here, we determined that DEHP exposure induced a compromised duodenum structure, which was concomitant with mitochondrial structural injury of epithelial cells. Importantly, DEHP exposure caused duodenum inflammatory epithelial cell damage and strong inflammatory response accompanied by activating the TLR4/MyD88/ NF-κB signaling pathway. Mechanistically, DEHP exposure directly inhibits the expression of AQP1 and thus leads to an inflammatory response, ultimately disrupting duodenum integrity and barrier function. Collectively, our findings uncover the role of AQP1 in phthalate-induced intestinal disorders, and AQP1 could be a promising therapeutic approach for treating patients with intestinal disorders or inflammatory diseases.

show abstract

“…In fact, although with some conflicting results (Lin et al, 2023), this condition has been reported to exert a greater toxic action on the reproductive capacity of zebrafish increasing the GSI, inhibiting spermatogenesis, oocyte development, destroying hormonal homeostasis and causing a reduction in the number and quality of eggs (Amereh et al, 2020). Additionally, also the combined impact of NPs and other endocrine disruptors, for example, bisphenols, for which some preliminary data support a significantly increased uptake and some possible exacerbated eco-toxicological effects in case of co-exposure, need to be deeply addressed (Chen et al 2017; Zheng et al 2023). Nanoscale-plastics can affect the zebrafish development through maternal transfer of NPs to the offsprings (Pitt et al, 2018), supporting the need for future investigation specifically focused on transgenerational effects.…”

Section: Discussionmentioning

confidence: 99%

The endocrine disrupting effects of nanoplastic exposure: A systematic review

Leso,

Battistini,

Vetrani

et al. 2023

Toxicol Ind Health

View full text Add to dashboard Cite

Good mechanical properties and low costs have led to a global expansion of plastic production and use. Unfortunately, much of this material can be released into the environment as a waste product and cleaved into micro- and nanoplastics (NPs) whose impact on the environment and human health is still largely unknown. Considering the growing worldwide awareness on exposure to chemicals that can act as endocrine disruptors, a systematic review was performed to assess the impact of NPs on the endocrine function of in vitro and in vivo models. Although a limited number of investigations is currently available, retrieved findings showed that NPs may induce changes in endocrine system functionality, with evident alterations in reproductive and thyroid hormones and gene expression patterns, also with a trans-generational impact. Nanoplastic size, concentration, and the co-exposure to other endocrine disrupting pollutants may have an influencing role on these effects. Overall, although it is still too early to draw conclusions regarding the human health risks derived from NPs, these preliminary results support the need for further studies employing a wider range of plastic polymer types, concentrations, and time points as well as species and life stages to address a great variety of endocrine outcomes and to achieve a broader and shared consensus on the role of NPs as endocrine disruptors.

show abstract

Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus)

Cited by 24 publications

References 58 publications

Comparative studies on the intestinal health of wild and cultured ricefield eel (Monopterus albus)

Comparative studies on the intestinal health of wild and cultured ricefield eel (Monopterus albus)

AQP1 Deficiency Drives Phthalate-Induced Epithelial Barrier Disruption through Intestinal Inflammation

The endocrine disrupting effects of nanoplastic exposure: A systematic review

Contact Info

Product

Resources

About