Combined extracts of Echinacea angustifolia DC. and Zingiber officinale Roscoe in softgel capsules: Pharmacokinetics and immunomodulatory effects assessed by gene expression profiling

Dall’Acqua, Stefano; Grabnar, Iztok; Verardo, Roberto; Klaric, Enio; Marchionni, Luigi; Imada, Eddie Luidy; Sut, Stefania; Agostinis, Chiara; Bulla, Roberta; Perissutti, Beatrice; Voinovich, Dario

doi:10.1016/j.phymed.2019.153090

Cited by 14 publications

(6 citation statements)

References 44 publications

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“…It also showed antiviral potential against avian influenza virus H9N2 on Vero cells in a dose-dependent manner (Rasool et al, 2017). Oral administration of Soft gel capsules containing a Z. officinale in combination showed immunomodulatory and anti-inflammatory properties parallel to those exerted by positive control, and gene expression data highlighted overall same transcriptional remodeling (Dall'Acqua et al, 2019). A study on essential oil of ginger reported immunomodulatory effects by improving the humoral immunity in cyclophosphamide-immunosuppressed mice in a dose-dependent manner (Carrasco et al, 2009).…”

Section: Zingiber Officinale Roscoe (Ginger)mentioning

confidence: 90%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory distress syndrome (ARDS) caused by systemic inflammatory reactions due to the excessive release of pro-inflammatory cytokines and chemokines by the immune effector cells. In India too, it is spreading very rapidly, although the case fatality rate is below 1.50% (https://www.statista.com), which is markedly less than in other countries, despite the dense population and minimal health infrastructure in rural areas. This may be due to the routine use of many immunomodulator medicinal plants and traditional AYUSH formulations by the Indian people. This communication reviews the AYUSH recommended formulations and their ingredients, routinely used medicinal plants and formulations by Indian population as well as other promising Indian medicinal plants, which can be tested against COVID-19. Special emphasis is placed on Indian medicinal plants reported for antiviral, immunomodulatory and anti-allergic/anti-inflammatory activities and they are categorized for prioritization in research on the basis of earlier reports. The traditional AYUSH medicines currently under clinical trials against COVID-19 are also discussed as well as furtherance of pre-clinical and clinical testing of the potential traditional medicines against COVID-19 and SARS-CoV-2. The results of the clinical studies on AYUSH drugs will guide the policymakers from the AYUSH systems of medicines to maneuver their policies for public health, provide information to the global scientific community and could form a platform for collaborative studies at national and global levels. It is thereby suggested that promising AYUSH formulations and Indian medicinal plants must be investigated on a priority basis to solve the current crisis.

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Section: Zingiber Officinale Roscoe (Ginger)mentioning

confidence: 90%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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“…A marked reduction in eosinophil, neutrophil, and monocyte accumulation in the bronchoalveolar lavage fluid and lung tissue suggested ginger constituents as putative suppressors of the Th2-mediated pulmonary inflammation in ovalbumin (OVA)- and house dust mite-sensitized mouse models. An exploratory ( n = 10) oral administration of softgel capsules containing a combination of Echinacea (5 mg) and ginger (25 mg) equivalent to 5.5 mg of 6-gingerol, 1.5 mg of 6-shogaol, and 1 mg of dodeca-2 E ,4 E ,8 Z ,10 E/Z -tetraenoic isobutylamides resulted in the peak concentrations of tetraene, 6-gingerol, 6-shogaol, and their glucuronide metabolites in the range of 5–29 ng/mL and generated a robust gene expression data set highlighting immunomodulatory and anti-inflammatory effects similar to those exerted by hydrocortisone …”

Section: Immunomodulators (Inflammation Relief)mentioning

confidence: 99%

“…An exploratory (n = 10) oral administration of softgel capsules containing a combination of Echinacea (5 mg) and ginger (25 mg) equivalent to 5.5 mg of 6-gingerol, 1.5 mg of 6-shogaol, and 1 mg of dodeca-2E,4E,8Z,10E/Z-tetraenoic isobutylamides resulted in the peak concentrations of tetraene, 6-gingerol, 6-shogaol, and their glucuronide metabolites in the range of 5−29 ng/mL and generated a robust gene expression data set highlighting immunomodulatory and anti-inflammatory effects similar to those exerted by hydrocortisone. 126 ■ RESPIRATORY SUPPORT (EXPECTORANTS) Terminal respiratory surfaces are covered with surfactants consisting of a phospholipid mixture together with four major surfactant proteins that prevent alveolar collapse and improve the pulmonary function. 127 The mucosal surfaces of the large airways (luminal diameter >2 mm) are further covered with mucus products of secretory cells that isolate, capture, neutralize, and launch immune responses against environmental pathogens 128 (Figure 1).…”

Section: ■ Immunomodulators (Inflammation Relief)mentioning

confidence: 99%

Plant-Based Support of Respiratory Health during Viral Outbreaks

Rathinasabapathy

Sakthivel

Komarnytsky

2022

J. Agric. Food Chem.

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Respiratory viruses are linked to major epidemic events that have plagued humans through recorded history and possibly much earlier, ranging from common colds, influenza, and coronavirus infections to measles. However, difficulty in developing effective pharmaceutical solutions to treat infected individuals has hindered efforts to manage and minimize respiratory viral outbreaks and the associated mortality. Here we highlight a series of botanical interventions with different and often overlapping putative mechanisms of action to support the respiratory system, for which the bioactive pharmacophore was suggested and the initial structure−activity relationships have been explored (Bupleurum spp., Glycyrrhiza spp., Andrographis spp.), have been proposed with uncertainty (Echinacea spp., Zingiber spp., Verbascum spp., Marrubium spp.), or remained to be elucidated (Sambucus spp., Urtica spp.). Investigating these metabolites and their botanical sources holds potential to uncover new mediators of the respiratory health outcomes as well as molecular targets for future break-through therapeutic interventions targeting respiratory viral outbreaks.

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“…Makrofajların aktivasyonu, B ve T lenfositler ile DKH üzerindeki etkileri bakımından önemli olan Echinacea katkılı diyetle 14 gün süreyle beslenen yaşlı farelerin kemik iliğinde DKH üretiminin ve olgun fonksiyonel DKH hücre sayısının genç farelerin düzeyine ulaştığı bildirilmiştir [48]. Ayrıca, Echinacea da bulunan yüksek molekül ağırlıklı polisakkaritlerin immun sistem üzerinde, özellikle fagositoz olmak üzere non-spesifik uyarıcı etkiye sahip olduğu da rapor edilmiştir [49]. Echinacea'nın etkinliğinin araştırıldığı başka bir çalışmada 42 gün boyunca atlara Echinacea özütleri uygulanmış, çalışmanın sonucunda uygulanan özütün sadece bağışıklık sistemini güçlendirmekle kalmadığı aynı zamanda hemoglobin seviyesi ve eritrosit sayısında da artışlara neden olduğu tespit edilmiştir [50].…”

Section: Echinaceaunclassified

Herbal Immunomodulators and Possibilities for Use on Animal Health

Yanar

Aktaş

2021

Muş Alparslan Üniversitesi Fen Bilimleri Dergisi

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İmmunomodülatörler, bağışıklık sistemini etkileyerek immun sistem üzerinde uyarıcı veya baskılayıcı etki gösteren veya bu sistem üzerinde regüle edici özelliklere sahip maddeler olarak tanımlanmaktadır. Bu maddeler arasında, bakteri ve bakteriyel ürünler, bitkisel immunmodülatörler, hayvansal ekstraktlar, aşılar, kompleks karbonhidratlar, besinsel faktörler, sitokinler ve sentetik bir kısım kimyasal bileşikler sayılabilir. Doğada aynı zamanda immunmodülatör etkili birçok bitki de bulunmaktadır. Bu derleme çalışmasında, immunmodülatör etkili bitkiler, bunların içerdikleri etkin maddeler ile bu maddelerin etki şekilleri detaylı olarak incelenmiştir. Çalışmanın amacı, söz konusu bitkisel immunmodulatörlerin pet hayvanlarının, ruminantların ve atların tedavilerinde kullanım olanaklarının araştırılmasıdır.

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Combined extracts of Echinacea angustifolia DC. and Zingiber officinale Roscoe in softgel capsules: Pharmacokinetics and immunomodulatory effects assessed by gene expression profiling

Cited by 14 publications

References 44 publications

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Plant-Based Support of Respiratory Health during Viral Outbreaks

Herbal Immunomodulators and Possibilities for Use on Animal Health

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