Combined hamartoma of the retina and retinal pigment epithelium. Anti-VEGF treatment of the associated choroidal neovascular membranes

Echevarría, L.; Villena, O.; Nievas, T.; Bellido, Rocío

doi:10.1016/j.oftale.2015.03.003

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…Present case series as well as cases of CHRRPE associated with CNVM described in literature[ 4 5 7 8 ] share a common peripapillary topography of hamartoma. Sarks[ 9 ] in his clinico-pathological correlation showed that peripapillary CNVM (idiopathic or secondary) originate either from choroidal vessels passing through a defect in Bruch membrane or from choroidal vessels that extend around the termination of Bruch membrane adjacent to the optic disc.…”

Section: Discussionmentioning

confidence: 96%

“…CHRRPE has been considered as a congenital benign entity with a lack of evidence in literature on the natural course of the disease. However, in recent times, few reports have highlighted the association of CHRRPE with vitreous hemorrhage,[ 2 ] preretinal neovascularization,[ 3 ] and choroidal neovascularization (CNVM)[ 2 4 5 6 7 8 ] contributing to the vision loss in CHRRPE.…”

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confidence: 99%

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Choroidal neovascularization associated with combined hamartoma of retina and retinal pigment epithelium: Multimodal imaging

Gupta

Pappuru

Dave

et al. 2018

Indian J Ophthalmol

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Combined hamartoma of retina and retinal pigment epithelium (CHRRPE) has been considered as a congenital benign entity with evidence of choroidal neovascularization membranes (CNVM) being associated with it in literature. This case series gives insight into the pathogenesis and the predisposing factors leading to CNVM formation in peripapillary CHRRPE using swept-source optical coherence tomography. In addition, lack of typical markers of CNVM (subretinal fluid/pigment epithelial detachment) in CHRRPE highlights the utility of optical coherence tomography angiography and the subtle optical coherence tomography findings such as “Bridge Sign” that could be instrumental in early diagnosis of CNVM in CHRRPE.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Choroidal neovascularization associated with combined hamartoma of retina and retinal pigment epithelium: Multimodal imaging

Gupta

Pappuru

Dave

et al. 2018

Indian J Ophthalmol

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“…6 In previously reported cases, a secondary CNVM occurred with peripapillary CHRRPE rather than macular or peripheral lesions. 2,3,9–11 Only one other case described a subfoveal CNVM, and that case showed only mild macular traction. 4 To our knowledge, this is the first known association of significant macular traction with a large, subfoveal CNVM lesion in CHRRPE.…”

Section: Discussionmentioning

confidence: 99%

“…A review of other cases in the literature of CHRRPE with a CNVM is presented in Table 1. 2–4,6,10,11 CNVM is estimated to occur in 6% of CHRRPE cases. 6 In previously reported cases, a secondary CNVM occurred with peripapillary CHRRPE rather than macular or peripheral lesions.…”

Section: Discussionmentioning

confidence: 99%

Secondary Choroidal Neovascularization in Combined Hamartoma of the Retina and Retinal Pigment Epithelium

Besirli

2022

Journal of VitreoRetinal Diseases

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Purpose: To report a 4-year-old boy with a large, macula-involving combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) lesion with an associated choroidal neovascular membrane involving the fovea, characterized with multimodal imaging. Methods: Case report. Results: Given the low likelihood of visual improvement with intervention, observation was recommended and the CHRRPE remained stable on follow-up 4 months after presentation. Conclusion: CHRRPE is a rare congenital retinal lesion that is variably pigmented. Awareness of rare complications, such as CNVM, as seen in this pediatric case is paramount.

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Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Lazzarini¹,

Al-Khersan²,

Patel³

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To describe the first reported case of combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) associated with a remote choroidal neovascular membrane (CNVM). Observations A 19-month-old girl with a normal prenatal and infantile history presented with esotropia of the left eye. Fundus examination demonstrated a large, elevated, charcoal-colored lesion in the nasal equatorial retina. There was dragging of the nasal retinal vessels and a retinal fold, presumed to have resulted from nasal traction from the lesion. There was also subretinal hemorrhage in the peripapillary macula. Multimodal imaging demonstrated a peripapillary choroidal neovascular membrane (CNVM) underlying the retinal fold. There was no leakage within the tumor or secondary retinal neovascularization. Examination of the fellow eye was unremarkable. The patient was diagnosed with peripheral CHRRPE with associated peripapillary CNVM. She was treated with serial intravitreal bevacizumab to the affected eye which resulted in a reduction in leakage from the CNVM and resolution of the subretinal hemorrhage. The CHRRPE remained stable on follow-up. Conclusions Peripheral CHRRPE can rarely be associated with a remote CNVM.

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Combined hamartoma of the retina and retinal pigment epithelium. Anti-VEGF treatment of the associated choroidal neovascular membranes

Cited by 5 publications

References 9 publications

Choroidal neovascularization associated with combined hamartoma of retina and retinal pigment epithelium: Multimodal imaging

Choroidal neovascularization associated with combined hamartoma of retina and retinal pigment epithelium: Multimodal imaging

Secondary Choroidal Neovascularization in Combined Hamartoma of the Retina and Retinal Pigment Epithelium

Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

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