Combined Hepatic and Pulmonary Metastasectomies From Colorectal Carcinoma. Data From the Prospective Spanish Registry 2008–2010

Jarabo, José Ramón; Gómez, Ana María; Calatayud, Joaquín; Fraile, Carlos; Fernández, Elena; Pajuelo, Núria; Flor, Raúl Embún; Molins, Laureano; Rivas, Juán J.; Hernando, F.J. Serrano

doi:10.1016/j.arbres.2017.10.003

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…However, when taking into consideration the indications for PM, other factors such as preoperative levels of some of the selected biomarkers also play a relatively important role. A number of authors point out the negative impact of preoperative CEA elevation on the prognosis of patients who underwent PM (5,(12)(13)(14)(15), which corresponds with our findings in the case of OS. However, in our cohort, the preoperative elevation of two more biomarkers, TPS and CA 19-9, was shown to be significantly linked to a worse OS and DFS.…”

Section: Discussionsupporting

confidence: 90%

Outcomes and Prognostic Factors Following Surgical Treatment of Pulmonary Metastases from Colorectal Carcinoma

et al. 2020

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Background/Aim: The lungs are the second most common site of cancer dissemination. The aim of this study was to analyze a cohort of patients operated for pulmonary metastases from colorectal carcinoma over a period of 18 years. Patients and Methods: In a group of 104 patients, relations were sought between overall survival or diseasefree survival and preoperative levels of selected biomarkers, number of metastases and the condition of the intrathoracic lymphatic nodes. Median observation period was 63 months. Results: The 5-year survival rate was 54.3%. Risk of disease progression and risk of death increases in case of occurrence of 2 or more metastases, affection of intrathoracic lymph nodes and levels of CA 19-9, TPS or CEA above cut-off value. Conclusion: Prognostic factors that determine overall survival as well as disease-free survival are the number of metastases, the condition of intrathoracic lymphatic nodes and the preoperative levels of biomarkers.

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Section: Discussionsupporting

confidence: 90%

Outcomes and Prognostic Factors Following Surgical Treatment of Pulmonary Metastases from Colorectal Carcinoma

et al. 2020

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“…On the contrary, a study showed increased mortality when synchronous resection of the primary with major hepatectomy (PMTR), with surgical mortality rate of up to 17% (22). However, for carefully selected patients with oligo-metastatic disease, palliative colectomy and surgery of metastases could bring long term survival (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study

Qiao

Fu³

et al. 2022

Front. Surg.

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BackgroundColon cancer remains one of the most common malignancies and we aimed to evaluate whether surgery has an effect on the survival of metastatic colon patients.MethodsWe analyzed 7,583 metastatic colon patients from the Surveillance, Epidemiology, between January 2010 and December 2015. Using Cox proportional hazards models and Kaplan-Meier curves, the overall survival rate (OS) and cancer-specific survival rate and End Results (SEER) registry (CSS) months (m) were evaluated with corresponding 95% confidence intervals (95% CIs). Propensity score matching (PSM) was performed to adjust for potential baseline confounding of all comparison groups.ResultsIn general, receiving both primary and metastatic tumor resection (PMTR) remarkably improved OS and CSS compared with only primary tumor resection (PTR) after PS matching (PSM) (P < 0.05), with a significantly improved OS (HR = 0.74, 95%CI = 0.69–0.80) and CSS (HR = 0.71, 95%CI = 0.66–0.76) in all stage M1 colon patients. The stratification analysis indicated a significant difference between OS and CSS in M1a and M1b stages. After PSM, PMTR was found to be associated with remarkably improved OS and CSS for patients with liver metastases but not associated with OS and CSS of patients with lung metastases in both M1a and M1b stage.ConclusionsThe results from this large SEER cohort supported PMTR might improve the survival of colon patients with liver metastases on the basis of chemotherapy.

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“…Preoperative prognosis can impact smoking that gives a HR of 2.72 (1.18–6.25, p = 0.002) or elevated CEA over 10 ng/dL. 34 35 Additionally, pulmonary metastasis to bilateral lungs or multiple lesions also offers worse prognosis compared with an isolated peripheral lesion. For patients having treatment for both hepatic and pulmonary metastasis, those with limited hepatic disease and resectable pulmonary metastasis can still have good long-term survival.…”

Section: Prognosismentioning

confidence: 99%

“…11 17 36 Patients with both liver and lung metastasis that have resection tend to have a similar prognosis compared with patients who have lung metastasis alone. 34 37 Patients with lung and liver disease also have better prognosis than patients with noncolorectal lymph node metastasis or peritoneal disease. 36 Relative risk of death was lowest for the combination of liver and lung metastasis 1.49 (95% CI = 1.34–1.66) compared with 1.59 (95% CI = 1.16–2.17) for peritoneal metastasis and 1.7 (95% CI = 1.57–1.84) for extrahepatic lymph nodes.…”

Section: Prognosismentioning

confidence: 99%

Surgical and Interventional Management of Lung Metastasis: Surgical Assessment, Resection, Ablation, Percutaneous Interventions

Stefanou

2022

Clin Colon Rectal Surg

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The lungs are the second most common site of metastases for colorectal cancer after the liver. Pulmonary metastases can be identified at the time of diagnosis of the primary tumor, or metachronously. About 20% of patients with colorectal cancer will develop pulmonary metastases. The best options for treatment include a multidisciplinary treatment approach consisting of surgical resection whenever possible, and chemotherapy. Surgical options most often include minimally invasive segmentectomy or wedge resection, while patients unable to have surgery may benefit from radio frequency ablation or radiation treatment. Prognosis is dependent on preoperative carcinoembryonic antigen level, number, and location of metastatic lesions, and resectability of primary tumor. Overall, pulmonary metastases are best treated by complete resection whenever possible.

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Combined Hepatic and Pulmonary Metastasectomies From Colorectal Carcinoma. Data From the Prospective Spanish Registry 2008–2010

Cited by 7 publications

References 29 publications

Outcomes and Prognostic Factors Following Surgical Treatment of Pulmonary Metastases from Colorectal Carcinoma

Outcomes and Prognostic Factors Following Surgical Treatment of Pulmonary Metastases from Colorectal Carcinoma

Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study

Surgical and Interventional Management of Lung Metastasis: Surgical Assessment, Resection, Ablation, Percutaneous Interventions

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