Combined Hepatocellular Carcinoma and Fibrolamellar Carcinoma Presenting as Two Adjacent Separate Lesions in a Young Boy: First Case Report from Asia

Singh, Pradyumn; Ramakrishna, Banumathi

doi:10.1155/2013/101862

Cited by 1 publication

(3 citation statements)

References 12 publications

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“…The second case had two contiguous masses in the right lobe that were separated by a rim of fibrous tissue that surrounded the classical HCC component, which was the largest tumor. The smaller mass represented the FLC [ 9 ]. As in our case, there are only three previous reports that describe a single hepatic mass composed of the two mixed histologic subtypes [ 5 – 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Two other cases describe synchronous tumors [5, 8, 9]. Both the molecular background and the pathogenesis of FLC are obscure and limited, possibly owing to the relatively low number of cases studied by individual groups [10].…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge, only three cases of a liver carcinoma with elements of both classical HCC and FLC intimately mixed within one mass have been reported [ 6 , 7 ]. Two other cases describe synchronous tumors [ 5 , 8 , 9 ]. Both the molecular background and the pathogenesis of FLC are obscure and limited, possibly owing to the relatively low number of cases studied by individual groups [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern

Castro-Villabón

Barrera-Herrera

Rodríguez‐Urrego

et al. 2015

Case Reports in Pathology

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Fibrolamellar carcinoma (FLC) is an uncommon form of primary liver malignancy with unique clinical, histological, and biological characteristics. It is usually seen in young adults without underlying liver disease. Histologically, it shows large cells with abundant eosinophilic cytoplasm, large vesicular nuclei, prominent nucleoli, and lamellar type fibrosis. In contrast, classical hepatocellular carcinoma (HCC) is typically present in elderly male patients with cirrhosis. It is the most common histological subtype, and it is characterized by its resemblance to the normal liver, both in its growth pattern and its cytology. The unusual case of a liver carcinoma that presented with histological features of both FLC and classical HCC is herein reported. This was the case of a 37-year-old female complaining of diffuse abdominal discomfort and epigastric pain for two months. She was referred to us for further management after she was diagnosed with HCC in a noncirrhotic liver. She underwent a left-sided hepatectomy. A yellow nodular mass with well-defined borders and a necrotic center was present in the resection specimen. The morphological features and immunohistochemical studies were consistent with a diagnosis of FLC mixed with classical HCC. The patient was followed up for five months, and no signs of recurrence were evident.

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Section: Discussionmentioning

confidence: 99%