Combined Hepatocellular-Cholangiocarcinoma with Variabl Sarcomatous Transformation

Nakajima, Tohru; Kubosawa, Hitoshi; Kondō, Yōichirō; Konno, Akihisa; Iwama, Shosuke

doi:10.1093/ajcp/90.3.309

Cited by 43 publications

(31 citation statements)

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“…Morphologically, the 2 cell types can exist in 1 of 3 ways, namely, separately (i.e., double cancer), contiguously but independently, or intermingled within a mass. Sarcomatoid transformation of cHCC-CC is extremely rare and is defined in histopathology as areas showing the proliferation of spindle-shaped cells and pleomorphic malignant cells with bizarre nuclei and abundant mitoses [1][2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Combined hepatocellular and cholangiocarcinoma with sarcomatoid transformation: radiologic–pathologic correlation of a case

et al. 2009

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A 71-year-old man presented to our hospital with 3-week history of fever in the background of loss of both weight and appetite over the past 3 months. He was found to have a large 10-cm mass in the right lobe of the liver on a triple-phase computed tomographic scan. The tumor showed a distinct fatty component, with areas of arterial enhancement and venous washout suggestive of hepatocellular carcinoma (HCC), another component showing progressive and late enhancement suggestive of cholangiocarcinoma (CC), and a third component showing persistent hypoenhancement relative to the liver parenchyma. He underwent surgical resection. This was histopathologically a biphasic tumor composed of areas showing hepatocytic differentiation, in contiguity with areas showing infiltrative glands set within fibrous stroma in keeping with combined hepatocellular and cholangiocarcinoma (cHCC-CC). A third component of pleomorphic spindle and epithelioid appearance in keeping with sarcomatous transformation was also found intimately related to the CC component. The patient developed extensive thoracic and abdominal metastases 2 months after surgery and died shortly after.

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Section: Discussionmentioning

confidence: 99%

Combined hepatocellular and cholangiocarcinoma with sarcomatoid transformation: radiologic–pathologic correlation of a case

et al. 2009

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“…The entity of the combined HCCC has been established in the field of human pathology with several detailed histopathological and immunohistochemical descriptions [4,5,7,10]. As in humans, combined HCCCs are extremely rare tumors in dogs.…”

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confidence: 99%

Combined Hepatocellular and Cholangiocellular Carcinoma in a Dog.

2001

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ABSTRACT. A transitional type of combined hepatocellular and cholangiocellular carcinoma developed in a 12-year-old male Yorkshire terrier dog. The tumor was histologically composed of both hepatocellular carcinoma and cholangiocellular carcinoma components, and both elements were closely intermingled. Intraluminal mucin accumulation in cytokeratin-positive tubular/glandular structures was observed within the cholangiocellular carcinoma components and this feature was useful histological marker for a differential diagnosis between combined hepatocellular and cholangiocellular carcinoma and a pseudoglandular type of hepatocellular carcinoma. This primary hepatic tumor is extremely rare in dogs.

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“…She and Szakacs suggested that an aberrant multipotent stem cell origin was a likely explanation of carcinosarcoma of the liver, because of the variability observed in their cases (14). By contrast, others claim 'conversion' tu- mor, which suggest that the transformation or the dedifferentiation of conventional HCC into sarcomatous components may occur (3,4,16,18), based on the observation that the transitional zones were identified in the tumor (16,18).…”

Section: Discussionmentioning

confidence: 99%

“…While it has been demonstrated that carcinosarcoma could arise from a variety of tissues including the esophagus, gallbladder, pancreas and uterus, primary carcinosarcoma of the liver is very rare; as far as we could identify, only 18 case reports in the English language literature have demonstrated primary carcinosarcoma of the liver to date (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), yet the number of case reports has recently been increasing (11)(12)(13)(14)(15)(16)(17)(18)(19), probably due to the increased recognition of the tumor. The epidemiology and risk factors have not yet been determined, and apparently the prognosis is poor except for cases in whom curative resection is performed (18).…”

Section: Introductionmentioning

confidence: 94%

Carcinosarcoma of the Liver

et al. 2010

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Herein we present a 73-year-old man with primary carcinosarcoma of the liver, a rare malignant tumor of the liver. The case was followed up due to HBV-related liver cirrhosis. Regular check-up by ultrasound demonstrated a hyperechoic tumor in the left lobe of the liver, and he was referred and admitted to our hospital. Dynamic CT studies revealed a mostly hypoenhancing hepatic mass with a peripheral ring enhancement. Surgical resection was performed, and the resected tumor was macroscopically a simple nodular type, 3 cm in diameter, with a dense fibrous capsule. Microscopically, undifferentiated cells were dominant in the tumor, while moderately differentiated hepatocellular carcinoma (HCC) were also observed. A transitional zone was noted between the undifferentiated tumor and HCC. Tumor tissue with adenocarcinoma, osteosarcoma and chondrosarcoma were also detected. Immunohistochemical studies demonstrated that tumor cells were HepPar 1 positive in hepatocellular carcinoma, and CK19 and partly CK7 positive in adenocarcinoma. Moreover, CD 56, chromogranin A and c-kit were occasionally positive in undifferentiated tumor cells. The diagnosis of carcinosarcoma was made based on the concomitant presence of HCC and sarcomatous components, yet it is noteworthy that various types of tumor cells were observed.

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Combined Hepatocellular-Cholangiocarcinoma with Variabl Sarcomatous Transformation

Cited by 43 publications

References 0 publications

Combined hepatocellular and cholangiocarcinoma with sarcomatoid transformation: radiologic–pathologic correlation of a case

Combined hepatocellular and cholangiocarcinoma with sarcomatoid transformation: radiologic–pathologic correlation of a case

Combined Hepatocellular and Cholangiocellular Carcinoma in a Dog.

Carcinosarcoma of the Liver

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