Combined hydrothermal pre-treatment and enzymatic hydrolysis of corn fibre: Production of ferulic acid extracts and assessment of their antioxidant and antiproliferative properties

Valério, Rita; Serra, Ana Teresa; Baixinho, João; Cardeira, Martim; Fernández, Naiara; Bronze, Maria Rosário; Duarte, Luís C.; Tavares, Maria L.; Crespo, João G.; Brazinha, Carla

doi:10.1016/j.indcrop.2021.113731

Cited by 28 publications

(8 citation statements)

References 66 publications

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“…However, corn fiber is a rich and natural source of arabinoxylan, if extracted and purified properly. Besides arabinoxylan, corn fiber extract is also rich in ferulic acid, a crosslinker of arabinoxylan, and a known antioxidant and precursor of bio-vanillin [6,7]. The extraction method of arabinoxylan from corn fiber can influence its biological properties since it affects the final molecular weight, branching and ferulic acid content [5].…”

Section: Introductionmentioning

confidence: 99%

Arabinoxylan from Corn Fiber Obtained through Alkaline Extraction and Membrane Purification: Relating Bioactivities with the Phenolic Compounds

et al. 2023

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Arabinoxylan has prebiotic properties, as it is able to resist digestion in the small intestine and undergoes fermentation in the large intestine. In this work, arabinoxylan was extracted from corn fiber using an alkaline solution and further purified with membrane processing. It was found that the extracts were mainly composed of xylose (50–52%), arabinose (37–39%), galactose (9%) and glucose (1–4%), with an A/X ratio of 0.72–0.77. All the extracts were composed of phenolic compounds, including ferulic acid derivatives such as dimers, trimers and tetramers. The purified extract had a lower concentration of ferulic and p-coumaric acid (0.004 and 0.02 mg/mgdry_weight, respectively) when compared to raw extract (19.30 and 2.74 mg/mgdry_weight, respectively). The same effect was observed for the antioxidant activity, with purified extracts having a lower value (0.17 ± 0.02 µmol TEAC/mg) when compared to the raw extract (2.20 ± 0.35 µmol TEAC/mg). The purified extract showed a greater antiproliferative effect against the HT29 cell line with EC50 = 0.12 ± 0.02 mg/mL when compared to the raw extract (EC50 = 5.60 ± 1.6 mg/mL). Both raw and purified extracts did not show any cytotoxicity to the Caco-2 cell line in the maximum concentration tested (10 mg/mL).

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Section: Introductionmentioning

confidence: 99%

Arabinoxylan from Corn Fiber Obtained through Alkaline Extraction and Membrane Purification: Relating Bioactivities with the Phenolic Compounds

et al. 2023

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“…For example, quercetin (quercetin-4′-glucoside and quercetin-3,4′-diglucoside) is a flavonoid that has been proven to be the core functional component of the antioxidant activity of Allium cepa L., which is a red onion cultivar ( Metrani, Singh, Acharya, Jayaprakasha, & Patil, 2020 ). Ferulic acid, naringenin, naringenin chalcone, and eriodictyol are considered important phenolic and flavonoid substances of A. mongolicum Regel, which were also identified in other species, such as corn fibre ( Valério et al, 2021 ), citrus ( Kicinska et al, 2020 ), tomato fruit ( Tomas et al, 2017 ), and Thymus sibthorpii Bentham ( Kontogiorgis et al, 2016 ). In many previous studies, these metabolites have been proven to have strong antioxidant activity ( Williamson, Kay, & Crozier, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Drying enhances the antioxidant activity of Allium mongolicum Regel through the phenylpropane and AA-MA pathway as shown by metabolomics

Liu,

Yu,

Xie

et al. 2024

Food Chemistry: X

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“…HAs, including CA, CQA, GA, and FA, exert a wide variety of biological antioxidant, anti-inflammatory, antimicrobial, antiallergic, hepatoprotective, anticarcinogenic, antithrombotic, and antiviral activities. Studies in rats and piglets suggest that HAs play a role in increasing sperm viability, vasodilatory actions, enzyme activity modulation, transcriptional factor activation, gene expression, and signal transduction [161][162][163][164].…”

Section: Potential Health Benefitsmentioning

confidence: 99%

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases

et al. 2022

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Cardiovascular and metabolic diseases are a leading cause of death worldwide. Epidemiological studies strongly highlight various benefits of consuming colorful fruits and vegetables in everyday life. In this review, we aimed to revisit previous studies conducted in the last few decades regarding green-colored foods and their bioactive compounds in consideration of treating and/or preventing cardiovascular and metabolic diseases. This review draws a comprehensive summary and assessment of research on the physiological effects of various bioactive compounds, mainly polyphenols, derived from green-colored fruits and vegetables. In particular, their health-beneficial effects, including antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, cardioprotective, and lipid-lowering properties, will be discussed. Furthermore, the bioavailability and significance of action of these bioactive compounds on cardiovascular and metabolic diseases will be discussed in detail.

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Combined hydrothermal pre-treatment and enzymatic hydrolysis of corn fibre: Production of ferulic acid extracts and assessment of their antioxidant and antiproliferative properties

Cited by 28 publications

References 66 publications

Arabinoxylan from Corn Fiber Obtained through Alkaline Extraction and Membrane Purification: Relating Bioactivities with the Phenolic Compounds

Arabinoxylan from Corn Fiber Obtained through Alkaline Extraction and Membrane Purification: Relating Bioactivities with the Phenolic Compounds

Drying enhances the antioxidant activity of Allium mongolicum Regel through the phenylpropane and AA-MA pathway as shown by metabolomics

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases

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