Combined hyperthermia and radiotherapy for prostate cancer: a systematic review

Guévelou, Jennifer Le; Chirila, Monica Emilia; Achard, Vérane; P, Guillemin; Lorton, Orane; Uiterwijk, Johannes WE; Dipasquale, G.; Salomir, Rarès; Zilli, Thomas

doi:10.1080/02656736.2022.2053212

Cited by 21 publications

(9 citation statements)

References 75 publications

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“…HT acts as a radiosensitizer and makes tumor cells more susceptible to irradiation [ 15 ]. When combined with RT, HT can lead to increased cell death in cancer cells, help to shrink the tumor, and improve survival rates [ 16 ]. The results are presented in chronological order.…”

Section: Anti-cancer Effects Of Rt + Ht Treatmentmentioning

confidence: 99%

Combination Therapy of Radiation and Hyperthermia, Focusing on the Synergistic Anti-Cancer Effects and Research Trends

2023

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Despite significant therapeutic advances, the toxicity of conventional therapies remains a major obstacle to their application. Radiation therapy (RT) is an important component of cancer treatment. Therapeutic hyperthermia (HT) can be defined as the local heating of a tumor to 40–44 °C. Both RT and HT have the advantage of being able to induce and regulate oxidative stress. Here, we discuss the effects and mechanisms of RT and HT based on experimental research investigations and summarize the results by separating them into three phases. Phase (1): RT + HT is effective and does not provide clear mechanisms; phase (2): RT + HT induces apoptosis via oxygenation, DNA damage, and cell cycle arrest; phase (3): RT + HT improves immunological responses and activates immune cells. Overall, RT + HT is an effective cancer modality complementary to conventional therapy and stimulates the immune response, which has the potential to improve cancer treatments, including immunotherapy, in the future.

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Section: Anti-cancer Effects Of Rt + Ht Treatmentmentioning

confidence: 99%

Combination Therapy of Radiation and Hyperthermia, Focusing on the Synergistic Anti-Cancer Effects and Research Trends

2023

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“…Thus, iron oxide might in the future combine and enhance two cancer treatment strategies, hyperthermia and radiotherapy, that possess synergistic therapy potential. [263] From the new classes of materials, a MOF formulation, RiMO-301, is now in clinical trials for the radiotherapy of advanced tumors (Phase I: NCT03444714).…”

Section: Clinical Progressmentioning

confidence: 99%

Prospects of Nanoparticle-based Radioenhancement for Radiotherapy

Gerken

Gerdes

Pruschy

et al. 2023

Preprint

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Radiotherapy is a key pillar of solid cancer treatment. Despite high level of conformal dose deposition, radiotherapy is limited due to co-irradiation of organs-at risk and subsequent normal tissue toxicities. Nanotechnology offers an attractive opportunity for increasing the efficacy and safety of cancer radiotherapy. Leveraging the freedom of design and the growing synthetic capabilities of the nanomaterial-community, a variety of engineered nanomaterials have been designed and investigated as radiosensitizers or radioenhancers. While research so far has been primarily focused on gold nanoparticles and other high atomic number materials to increase the absorption cross section of tumor tissue, recent studies are challenging the traditional concept of high-Z nanoparticle radioenhancers and highlight the importance of catalytic activity. This review provides a concise overview on the fundamental knowledge of nanoparticle radioenhancement mechanisms and their quantification. It critically discusses potential radioenhancer candidate materials and general design criteria for different radiation therapy modalities, and concludes with research priorities in order to advance the development of nanomaterials, to enhance the efficacy of radiotherapy and to increase at the same time the therapeutic window.

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“…Thus, iron oxide might in the future combine and enhance two cancer treatment strategies, hyperthermia and radiotherapy, that possess synergistic therapy potential. 268 From the new classes of materials, a MOF formulation, RiMO-301, is now in clinical trials for the radiotherapy of advanced tumors (Phase I: NCT03444714).…”

Section: Clinical Progressmentioning

confidence: 99%