Combined impacts of microplastics and cadmium on the liver function, immune response, and intestinal microbiota of crucian carp (Carassius carassius)

Wei, Wei; Yang, Qiufeng; Xiang, Dan; Chen, Xiaoyun; Wen, Zhengrong; Wang, Xiaofu; Xu, Xiaoli; Cheng, Peng; Liu, Yang; Luo, Mingzhong; Xu, Junfeng

doi:10.1016/j.ecoenv.2023.115104

Cited by 25 publications

(2 citation statements)

References 61 publications

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“…MPs were able to influence lymphocyte subsets in the spleen of maternal and offspring mice ( Tang et al, 2022 ). Splenic toxicity of microplastics had also been reported in oryzias latipes ( Zhu et al, 2020 ) and carassius ( Wei et al, 2023 ), which data was absent on spleen in chicken. The specific mechanism of injury in it was worth exploring.…”

Section: Introductionmentioning

confidence: 86%

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

Guo,

Geng,

Zhang

et al. 2024

Poultry Science

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Section: Introductionmentioning

confidence: 86%

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

Guo,

Geng,

Zhang

et al. 2024

Poultry Science

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“…Currently, most studies have focused on coexposure to microplastics and persistent organic pollutants or heavy metal. For example, the combined exposure to MPs and Cd may exert synergistic toxic effects on crucian carp [ 16 ]. Coexposure to nanopolystyrene particles and BPA exhibited more serve toxicity on histopathology, oxidative stress, immune function, and intestinal microbiota in channel catfish [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Micro- and Nanoplastics at the Predicted Environmental Concentration on Functional State of Intestinal Barrier in Caenorhabditis elegans

Tan

Shi

et al. 2023

Toxics

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The possible toxicity caused by nanoplastics or microplastics on organisms has been extensively studied. However, the unavoidably combined effects of nanoplastics and microplastics on organisms, particularly intestinal toxicity, are rarely clear. Here, we employed Caenorhabditis elegans to investigate the combined effects of PS-50 (50 nm nanopolystyrene) and PS-500 (500 nm micropolystyrene) at environmentally relevant concentrations on the functional state of the intestinal barrier. Environmentally, after long-term treatment (4.5 days), coexposure to PS-50 (10 and 15 μg/L) and PS-500 (1 μg/L) resulted in more severe formation of toxicity in decreasing locomotion behavior, in inhibiting brood size, in inducing intestinal ROS production, and in inducting intestinal autofluorescence production, compared with single-exposure to PS-50 (10 and 15 μg/L) or PS-500 (1 μg/L). Additionally, coexposure to PS-50 (15 μg/L) and PS-500 (1 μg/L) remarkably caused an enhancement in intestinal permeability, but no detectable abnormality of intestinal morphology was observed in wild-type nematodes. Lastly, the downregulation of acs-22 or erm-1 expression and the upregulation expressions of genes required for controlling oxidative stress (sod-2, sod-3, isp-1, clk-1, gas-1, and ctl-3) served as a molecular basis to strongly explain the formation of intestinal toxicity caused by coexposure to PS-50 (15 μg/L) and PS-500 (1 μg/L). Our results suggested that combined exposure to microplastics and nanoplastics at the predicted environmental concentration causes intestinal toxicity by affecting the functional state of the intestinal barrier in organisms.

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Ecotoxicological effects of polystyrene nanoplastics on common carp: Insights into blood parameters, DNA damage, and gene expression

Acar,

İnanan,

Zemheri‐Navruz

2024

J of Applied Toxicology

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Plastics are ubiquitous in modern society due to their cost‐effectiveness, lightweight nature, and versatility. However, their extensive use and inadequate recycling have led to a significant environmental challenge, with plastic waste accumulating rapidly and causing ecological and health problems, especially in aquatic environments. Nanoplastics, particles ranging from 1 to 100 nm, have emerged as a particularly concerning subset due to their ability to easily penetrate biological barriers and accumulate in tissues. In this study, we investigated the toxicity of carboxylate‐modified polystyrene nanoplastics (PS‐NPs) on common carp (Cyprinus carpio), a species often used in ecotoxicology research due to its ability to accumulate pollutants. The PS‐NPs were characterized, and their effects on DNA damage gene expression related to oxidative stress and immunity were examined. PS‐NPs with a diameter of 20–30 nm were found to possess a spherical shape and negatively charged surfaces. Exposure to PS‐NPs led to significant DNA damage in the blood and brain cells of common carp, with higher concentrations resulting in more severe damage. Additionally, PS‐NP exposure influenced the expression of genes related to antioxidative defense and stress response in the liver. Specifically, genes encoding superoxide dismutase (SOD), catalase (CAT), and heat shock protein 70 (Hsp70) showed upregulation, while glutathione peroxidase (GPx) and glutathione S‐transferase (GST) exhibited downregulation at higher PS‐NP concentrations. Furthermore, the immune‐related genes interleukin‐1ß (IL‐1ß), interleukin‐8 (IL‐8), and tumor necrosis factor‐α (TNF‐α) displayed dose‐dependent downregulation in the liver tissue. These findings suggest that exposure to PS‐NPs induces oxidative stress, disrupts immune responses, and causes DNA damage in common carp. The results highlight the need for further research on the environmental impacts of PS‐NPs and underscore the importance of proper waste management and recycling practices to mitigate plastic pollution.

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Combined impacts of microplastics and cadmium on the liver function, immune response, and intestinal microbiota of crucian carp (Carassius carassius)

Cited by 25 publications

References 61 publications

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress

Combined Effects of Micro- and Nanoplastics at the Predicted Environmental Concentration on Functional State of Intestinal Barrier in Caenorhabditis elegans

Ecotoxicological effects of polystyrene nanoplastics on common carp: Insights into blood parameters, DNA damage, and gene expression

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