Combined Inflammation and Nutrition Factors Reinforce the Prognostic Prediction for Stage III Colorectal Cancer Patients

KATO, SHINYA; Miyoshi, Norikatsu; Fujino, Shiki; Minami, Soichiro; Matsuda, Chu; Yasui, Masayoshi; OHUE, MASAYUKI; Sekido, Yuki; Hata, Tsuyoshi; Ogino, Takayuki; Takahashi, Hidekazu; Uemura, Mamoru; Yamamoto, Hirofumi; Doki, Yuichiro; Eguchi, Hidetoshi

doi:10.21873/anticanres.16006

Cited by 3 publications

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“…Since the prognosis of cancer patients is strongly correlated with the components of TNM classification, such as the tumor depth and lymph node metastasis, treatment strategies, such as the indication for adjuvant chemotherapy, are often determined based on TNM classification in daily practice. However, many studies have reported that the prognosis is greatly influenced by not only the TNM classification but also host factors (4,5). One reason for this is that systemic inflammation and an increase or decrease in immunocompetent cells provide an environment in which the growth of micrometastasis is facilitated (12).…”

Section: Discussionmentioning

confidence: 99%

“…It is true that the TNM classification is closely related to the prognosis and is very useful in daily practice when determining treatment strategies, such as indications for adjuvant chemotherapy (2,3). However, it is also true that there are differences in the prognosis even within the same TNM stage (4,5). This may be because not only tumor factors, such as the tumor depth and lymph node metastasis, but also host factors, such as systemic inflammation and the nutritional status, are important factors affecting the prognosis of cancer patients.…”

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confidence: 99%

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Significance of the Prognostic Immune and Nutritional Index in Patients With Stage I-III Colorectal Cancer

Shibutani¹,

Kashiwagi²,

Fukuoka³

et al. 2023

CDP

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Background/Aim: Recently, the prognostic immune and nutritional index (PINI), which is calculated from the peripheral monocyte count and serum albumin level, has been reported to be useful as a prognostic marker in Korean and Chinese patients with colorectal cancer. The present study therefore examined the usefulness of the PINI as a marker for predicting the prognosis in Japanese colorectal cancer patients. Patients and Methods: A total of 529 patients who underwent curative surgery for stage I-III colorectal cancer between January 2015 and December 2019 were enrolled in this study. The PINI was calculated as [serum albumin concentration (g/dl)×0.9]–[peripheral monocyte count (mm3)×0.0007]. Results: The median PINI was 3.242 (range=1.250-4.091). A receiver operating characteristic curve analysis revealed that the appropriate cut-off value of the PINI was 3.047. The low-PINI group had significantly lower relapse-free and overall survival rates than the high-PINI group (p<0.0001, p<0.0001, respectively). Conclusion: The PINI based on host factors is useful as a prognostic marker for Japanese patients with stage I-III colorectal cancer.

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confidence: 99%

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confidence: 99%

Significance of the Prognostic Immune and Nutritional Index in Patients With Stage I-III Colorectal Cancer

Shibutani¹,

Kashiwagi²,

Fukuoka³

et al. 2023

CDP

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“…In addition to oncological factors and treatment factors, the outcomes of cancer treatment are greatly influenced by host factors, such as the nutritional status, immune status, systemic inflammation, and intestinal flora (1)(2)(3)(4)(5)(6). Malnutrition has been reported to be associated with shorter survival time after curative surgery and worse chemotherapeutic efficacy in patients with various gastrointestinal malignancies (7)(8)(9)(10)(11).…”

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confidence: 99%

Impact of Preoperative Nutritional Status on Long-term Survival in Patients With Stage I-III Colorectal Cancer

Shibutani¹,

Kashiwagi²,

Fukuoka³

et al. 2023

In Vivo

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Background/Aim: In addition to oncological and treatment factors, the outcomes of cancer treatment are greatly influenced by host factors, such as the nutritional status. The aim of this study was to evaluate the association between the preoperative nutritional status and the prognosis of colorectal cancer patients using three nutritional indices. Patients and Methods: The target cohort consisted of 529 patients with stage I-III colorectal cancer, who underwent curative surgery between January 2015 and December 2019. The nutritional indices were calculated according to the equations that follow. Prognostic nutritional index (PNI)=10×serum albumin concentration (g/dl) +0.005×peripheral lymphocyte count (/μl). Nutritional risk index (NRI)=15.19×serum albumin concentration (g/dl)+41.7×present weight/usual weight. Geriatric nutritional risk index (GNRI)=14.89×serum albumin concentration (g/dl)+41.7×present weight/ideal weight. Ideal weight was calculated as follows: height(cm)-100-[(height(cm)-150)/4] for men and height(cm)-100-[(height(cm)-150)/2.5] for women. Results: In common with all nutritional indices (PNI, NRI and GNRI), the low-nutritional index group had significantly lower relapse-free and overall survival rates than the high-nutritional index group. Furthermore, a subgroup analysis according to the NRI showed the association of the NRI with the patient prognosis for each stage. Conclusion: The preoperative nutritional status may have a close relationship with the prognosis in patients who receive curative surgery for colorectal cancer. Patients and MethodsPatients. The target cohort consisted of 529 patients with stage I-III colorectal cancer, who underwent curative surgery at the

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Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment

Tez

2024

World J Clin Oncol

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The prognosis of colorectal cancer (CRC) patients with peritoneal metastasis remains poor despite advancements in detection and treatment. Preoperative inflammatory and nutritional markers have emerged as significant predictors of prognosis in CRC, potentially guiding treatment decisions and improving patient outcomes. This editorial explores the prognostic value of markers such as the neutrophil-to-lymphocyte ratio, hemoglobin, and serum albumin levels. By integrating these markers into prognostic models, clinicians can better stratify patients, personalize treatment strategies, and ultimately enhance clinical outcomes. This review highlights the importance of these markers in providing a comprehensive assessment of patient condition and underscores the need for further research to validate their clinical utility and uncover underlying mechanisms.

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Combined Inflammation and Nutrition Factors Reinforce the Prognostic Prediction for Stage III Colorectal Cancer Patients

Cited by 3 publications

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Significance of the Prognostic Immune and Nutritional Index in Patients With Stage I-III Colorectal Cancer

Significance of the Prognostic Immune and Nutritional Index in Patients With Stage I-III Colorectal Cancer

Impact of Preoperative Nutritional Status on Long-term Survival in Patients With Stage I-III Colorectal Cancer

Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment

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