Combined Inhibition of c-Abl and PDGF Receptors for Prevention and Treatment of Murine Sclerodermatous Chronic Graft-versus-Host Disease

Zerr, Pawel; Distler, Alfiya; Palumbo‐Zerr, Katrin; Tomčík, Michal; Vollath, Stefan; Dees, Clara; Egberts, Friederike; Tinazzi, Ilaria; Galdo, Francesco Del; Distler, Oliver; Schett, Georg; Spriewald, Bernd; Distler, Jörg H W

doi:10.1016/j.ajpath.2012.07.017

Cited by 29 publications

(21 citation statements)

References 37 publications

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“…Mice were treated from d21 to d56 post transplantation. Mice undergoing syngeneic transplantation of bone marrow cells and splenocytes served as controls 29 30…”

Section: Methodsmentioning

confidence: 99%

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

et al. 2015

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“…Mice were treated from d21 to d56 post transplantation. Mice undergoing syngeneic transplantation of bone marrow cells and splenocytes served as controls 29 30…”

Section: Methodsmentioning

confidence: 99%

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

et al. 2015

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“…The B10.D2→Balb/c (H-2(d)) minor histocompatibility antigen-mismatched model was used as a model of SSc with systemic fibrosis 8 12 13. cGvHD was induced by allogeneic transplantation of 5×10 6 splenocytes and 1×10 6 bone marrow cells from B10.D2 mice into BALB/c (H-2d) mice as described.…”

Section: Methodsmentioning

confidence: 99%

Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies

et al. 2015

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“…Imatinib has shown promising results in clinical trials of steroid-refractory cGvHD patients (238, 239). An enhanced effect was observed by simultaneous targeting of both PDGFRα- and TGF-β signaling pathways using Imatinib and Nilotinib, the latter targeting c-Abl in the intracellular pathway induced by TGF-β (240). …”

Section: Chronic Gvhdmentioning

confidence: 99%

The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview

et al. 2016

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Bone marrow transplantation (BMT) is the only therapeutic option for many hematological malignancies, but its applicability is limited by life-threatening complications, such as graft-versus-host disease (GvHD). The last decades have seen great advances in the understanding of BMT and its related complications; in particular GvHD. Animal models are beneficial to study complex diseases, as they allow dissecting the contribution of single components in the development of the disease. Most of the current knowledge on the therapeutic mechanisms of BMT derives from studies in animal models. Parallel to BMT, the understanding of the pathophysiology of GvHD, as well as the development of new treatment regimens, has also been supported by studies in animal models. Pre-clinical experimentation is the basis for deep understanding and successful improvements of clinical applications. In this review, we retrace the history of BMT and GvHD by describing how the studies in animal models have paved the way to the many advances in the field. We also describe how animal models contributed to the understanding of GvHD pathophysiology and how they are fundamental for the discovery of new treatments.

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Combined Inhibition of c-Abl and PDGF Receptors for Prevention and Treatment of Murine Sclerodermatous Chronic Graft-versus-Host Disease

Cited by 29 publications

References 37 publications

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies

The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview

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