Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing

Deciphering two decades of cellular reprogramming in cancer: A bibliometric analysis of evolving trends and research frontiers

“…Cellular metabolic reprogramming is fundamental for the development of lung adenocarcinoma (LUAD). In LUAD, enzymes like PDK1 and LDHA are crucial for glucose metabolism and represent therapeutic targets [ 46 ], Genetic mutations in KRAS [ 47 ] and KEAP1 [ 48 ]influence glutamine metabolism, underscoring metabolic reprogramming's importance. The lncRNA FAM83A-AS1 [ 49 ], linked to glycolysis, also presents a potential target.…”