Combined Interferon-Antiviral therapy effectiveness against Hepatitis B viral infection in Babylon Province

Abstract

Hepatitis can be defined as one of the liver’s inflammations that might be caused via viral infections, toxins, drugs and alcohol. The hepatitis via viral infection can be classified according to the type of viral strain and symptom into (A, B, C, D, E), the Hepatitis B is specified as one of the dangerous diseases resulting from a virus that is infecting the liver and has the ability of causing life-long infection, liver failure, liver cancer, cirrhosis (liver scarring) and death. The current work is carried out for evaluating the interferon as well as antiviral treatment effect on the viral load and viral activity among certain group of Hepatitis B virus infected patients enrolled to GIT and liver center in Merjan Medical City using Real time PCR for viral load and viral copy number determination. The results show that the all recorded cases in GIT center about (3612 hepatitis virus at both B and C), 2226 for HBV and 1386 for HCV, only 566 HBV patients was analysis by PCR around the year 2016. The males were high significant than females in hepatitis B infections. The north area of Babylon province had higher percentage than south and middle areas. Low activity of treatment protocol was mentioned on HBV infected patients, where (38.62 %) of patients had final outcome as undetectable viral load after treatment with combined interferon and oral anti–viral drugs. Conclusion: was that the combination treatment of immunological derivative and oral treatment more effective than single treatment used in HBV infection.