Combined intra-articular glucocorticoid, bupivacaine and morphine reduces pain and convalescence after diagnostic knee arthroscopy

Abstract

(2002) Combined intra-articular glucocorticoid, bupivacaine and morphine reduces pain and convalescence after diagnostic knee arthroscopy, Acta Orthopaedica Scandinavica, 73:2, 175-178,

Comparisons of analgesic effects of different doses of morphine and morphine plus methylprednisolone after knee surgery

“…Reduction of postoperative pain by injecting opioid into the knee joint is believed to support the hypothesis that peripheral opioid receptors are activated in response to inflammation [13]. The use of opioid drugs such as fentanyl, morphine [14] and meperidine [15], or even combination therapy by using an opioid plus a non-opioid drug have also been reported to reduce postoperative pain [7,8].…”

“…Results of studies concerning postoperative analgesic effects of intra-articular administration of opioids are confusing [4][5][6]. Combination therapy by using an opioid plus a non-opioid drug has been proposed for alleviating postoperative pain [7,8]. Intra-articular glucocorticoid may also improve pain relief after arthroscopy possibly due to its effect on reducing inflammation [6,9].…”

“…; and Group M1M (n ϭ 19) received 1 mg morphine plus 40 mg methylprednisolone in 20 mL of isotonic saline intraarticularly and 5 mL of isotonic saline i.v. The doses of drugs were chosen on the basis of previous clinical studies [6,8,10]. The test drugs were given to the surgeon who injected the solution through the arthroscope at the end of the procedure without knowing the contents so as to ensure that the drug was delivered into the joint.…”

Abordaje del dolor agudo en traumatología

“…A pesar de todo, con frecuencia se utiliza bupivacaína después de artroscopias de rodilla, siendo un procedimiento eficaz y seguro (60)(61)(62). El empleo de bupivacaína, morfina y metilprednisolona en infiltración intraarticular después de artroscopias de tobillo, también logra una adecuada reducción del dolor y reduce la discapacidad (63).…”

A Randomized, Prospective, Double-Blind Study to Investigate the Effectiveness of Adding DepoMedrol to a Local Anesthetic Injection in Postmeniscectomy Patients With Osteoarthritis of the Knee

“…2 Administration after diagnostic arthroscopy or meniscectomy is noted to decrease postoperative pain scores, consumption of analgesics, and recovery time. 14,20,21 The cohort of patients with existing OA undergoing meniscectomy is potentially at higher risk of further joint degeneration and poor symptomatic outcomes, as the relative contribution of OA to the patient's symptoms may exceed that which is due to the meniscal injury. Postoperative corticosteroid injection may alleviate postoperative discomfort and improve the outcomes in this at-risk population.…”