The present study was conducted among twelve dogs of various breeds having mature cataract. Those dogs were randomly divided into two groups as A and B comprising six dogs in each group. Group B dogs were subjected for CTR placement, phacoemulsification and IOL implantation, and in Group A phacoemulsification followed by IOL implantation only. From all the dogs, blood samples were collected in EDTA coated as well as serum separation vials at different intervals during the observation period as follows: Preoperatively (0 day) and 1 st , 3 rd , 7 th , 14 th , 21 st , 30 th , 60 th , 90 th , 120 th , 150 th , 180 th and 210 th day post-operatively. Those blood samples were subjected for various haematological and biochemical analysis. Total erythrocyte count and haemoglobin values were within normal range in all dogs of both the groups, whereas an apparent increase in the total leukocyte count and neutrophil values during 1 st post-operative day was evident. The Lymphocytes, monocytes, eosinophils and basophils values were within the normal range. Alanine amino transferase, serum creatinine and blood glucose levels did not show any significant changes and were within the normal range in both the groups. Neither surgical procedure nor anaesthetic protocol did not alter the haemato-biochemical parameters.