Assisted conception is a women's health issue of growing importance, with the number of women undergoing in vitro fertilization (IVF) increasing worldwide. IVF treatment involves ovarian stimulation that can result in a hyperestrogenic state, and in turn can lead to ovarian hyperstimulation syndrome (OHSS), which is associated with both venous and arterial thromboembolism. This chapter addresses clinically relevant thrombotic and hemostatic aspects of assisted conception, including the diagnosis, treatment and prevention of OHSS-related thromboembolism.