Combined Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Gallbladder

Al-Brahim, Nabeel; Albannai, Raeda

doi:10.1007/s12022-012-9229-4

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…The present two cases of MiNENs of the gallbladder showed positive expression of both Syn and CgA on immunohistochemical staining of LCNEC, and further histological analysis showed large and pleomorphic cells arranged in solid sheets or organoid nests. Moreover, the tumor cells had large-sized round to oval nuclei with visible vesicular nuclei, some visible prominent nucleoli, coarse chromatin, abundant cytoplasm, quick mitotic activity (exceeding 20 mitoses/2 mm 2 ), a high Ki67 index of over 20%, and frequent large areas of necrosis, features consistent with the characteristics of LCNEC [ 4 , 39 , 44 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review

et al. 2022

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Background Mixed neuroendocrine–non-neuroendocrine neoplasms (MiNENs) of the gallbladder are rare malignancies. Here we presented two cases and reviewed the related literature. Case presentation Our two patients were postoperatively diagnosed with gallbladder MiNENs, which pathologically consisted of a large cell neuroendocrine carcinoma and papillary adenocarcinoma. After cholecystectomy, one patient had a survival time of 30 months, while the other remained alive through 12 months of follow-up. In the literature, a total of 72 cases of gallbladder MiNENs were identified, and with our two patients included, we calculated a male-to-female ratio of 0.22 and a mean age of 64.5 years for the 74 reported cases. About one-half of these patients were found to have gallstones and presented with abdominal pain or discomfort in a relatively early stage. The preoperative diagnosis of these 74 cases mainly relied on abdominal ultrasound, contrast-enhanced computed tomography (CT) scanning, and magnetic resonance imaging or positron emission tomography/CT. However, the final diagnosis was established based upon the pathological evidence and expression of synaptophysin (Syn) and/or chromogranin A identified by immunohistochemical staining or neurosecretory granules detected by electron microscopy. Fifty-eight patients (78.4%) underwent various operations including simple cholecystectomy (n = 14), en bloc cholecystectomy (n = 9), standard or non-standard radical cholecystectomy (n = 25), or extended radical cholecystectomy (n = 6). The mean size of the resected gallbladder masses was 50.8 ± 36.1 mm (n = 63) with regional lymph node metastasis in 37 patients (52.1%), liver invasion or staging greater than T3 in 33 patients (45.8%), and hepatic metastasis in 26 patients (35.1%). The postoperative median survival time was 36 ± 11.42 months (95% confidence interval, 13.62 to 58.38 months). The log-rank analysis did not find that postoperative adjuvant chemotherapy contributed to a longer survival time relative to that among the patients who did not receive chemotherapy (numbers of patients, 15 versus 43; survival times, 36 months versus 30 months, p > 0.05). Conclusions Our two cases and the cases in the literature suggest that MiNENs of the gallbladder predominantly occur in women; are associated with early lymph node metastasis, local hepatic invasion, and hepatic metastasis; and can be managed by various surgeries as well as chemotherapy combined with somatostatin analogs.

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Section: Discussionmentioning

confidence: 99%

Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review

et al. 2022

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“…[ 10 ] F/68 Negative Fundus 3 + Lymph node AC Cho, extended hepatectomy DFS, 12 11 Paniz et al . [ 11 ] F/48 AP Fundus 3.5 + Unclear AC Cho, extended hepatectomy Unknown 12 Al-Brahim and Albannai [ 12 ] M/45 AP, jaundice Fundus 5.7 + Unclear AC Cho, Che Unknown 13 Okuyam et al . [ 13 ] M/64 Abdominal fullness Fundus 2.5 + Lymph node - Biopsy, Che Died, 22 14 Nakagawa et al .…”

Section: Introductionmentioning

confidence: 99%

Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature

Liu

Wang

et al. 2015

World J Surg Onc

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Large-cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare. We present a 63-year-old Chinese female who was admitted with right upper quadrant pain and a quasi-circular tumor measuring 2.0 cm on the body of the gallbladder, as indicated by computed tomography. LCNEC combined with adenocarcinoma was immunohistochemically confirmed after open radical cholecystectomy. Postoperative recovery of this patient was uneventful, and no evidence of recurrence or metastasis was observed after 12 months of follow-up. LCNEC of the gallbladder is thought to be extremely rare and is usually found in combination with other histological carcinoma types, such as adenocarcinoma, as determined histologically. The prognosis is poor overall, but early detection with complete resection may result in a relatively good prognosis.

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Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature

et al. 2020

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Combined Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Gallbladder

Cited by 7 publications

References 11 publications

Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review

Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review

Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature

Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature

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