Combined Liver-Kidney Transplantation: Survey of a Single Center in Spain

Rodelo-Haad, Cristian; Rodríguez‐Benot, Alberto; Martinez-Vaquera, S.; Navarro-Cabello, M.D.; Morales, Maria Luisa Agüera; Mier, M.V. Pendón Ruiz de; Montero-Álvarez, José Luis; Mata-Garcia, M. de la; Briceño-Delgado, Javier; Aljama-García, Pedro

doi:10.1016/j.transproceed.2013.10.016

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…This appears to be surprising since the overall results and outcomes of LKTX procedures are acceptable but inferior to those of patients who undergo single-organ transplant procedures. 38,39 Thus, the fatigue scores found in the present study do not mirror the physical challenge that is represented by a double-organ transplant. However, almost 20% of patients from the OLT group stated that their health status had improved, whereas there were no patients from the LKTX group who marked a response of healthier than the year before.…”

Section: Discussioncontrasting

confidence: 68%

Untitled

Benzing

Krenzien²,

Krezdorn³

et al. 2017

Exp Clin Transplant

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Objectives: To date, fatigue is still poorly understood in recipients of orthotopic liver transplant and simultaneous/sequential liver and kidney transplant procedures. The present study examined the appearance of fatigue in patients who received orthotopic liver and sequential liver and kidney transplant procedures compared with the general population and the influence of various clinical and socioeconomic factors on fatigue levels. Materials and Methods: The Multidimensional Fatigue Inventory survey was sent to all patients with a history of orthotopic liver and simultaneous/sequential liver and kidney transplant. The results were compared to data from a reference population. Results: Our survey included 276 eligible patients: 256 recipients (92.7%) of orthotopic liver transplant and 20 recipients (7.3%) of simultaneous/sequential liver and kidney transplant. Significantly lower fatigue scores were found in the general population compared with both transplant groups (P < .001). There were also no significant differences between the transplant groups. Among the clinical and socioeconomic factors, history of hepatocellular carcinoma, chronic kidney disease, age, family status, and education had a significant impact on fatigue levels. Conclusions: This is the first study to compare fatigue in recipients of orthotopic liver and simultaneous/-sequential liver and kidney transplant. We found that fatigue is an important but still poorly understood outcome after transplant.

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Section: Discussioncontrasting

confidence: 68%

Untitled

Benzing

Krenzien²,

Krezdorn³

et al. 2017

Exp Clin Transplant

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“…According to the study by Hanish et al [ 5 ] on transplant recipients with dialysis history, SLKT generates better outcome than single kidney transplantation, liver transplantation followed by dialysis, or staged liver and kidney transplantation. Haad et al [ 34 ] and Xing et al [ 35 ] reached similar conclusions. In the present study, LT recipients with renal insufficiency had higher mortality at an early stage after surgery than SLKT recipients (LT vs. SLKT: 32% vs. 0%).…”

Section: Discussionsupporting

confidence: 57%

Long-Term Outcomes of Simultaneous Liver-Kidney Transplant Patients with Hepatitis B Compared to with Liver Transplant Alone

et al. 2016

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BackgroundThe number and survival rate of simultaneous liver-kidney transplant (SLKT) recipients have increased dramatically since 2002. However, the long-term effectiveness of SLKT in patients with hepatitis B is unknown.Material/MethodsForty-six patients who visited the Organ Transplant Center of the Shanghai First People’s Hospital between January 2001 and May 2005 had hepatitis B virus infection and renal failure (any degree), and underwent organ transplantation: 21 patients underwent SLKT and 25 patients underwent liver transplant (LT) alone.ResultsThe 1-, 3-, and 5-year survival rates of SLKT recipients were 90.5%, 81.0%, and 81.0%, respectively. Incidence of acute hepatic allograft rejection between SLKT recipients and LT recipients (33% vs. 16%) did not reach significance (P=0.170). Despite higher infection rate, more prevalent hepatitis B relapse, and longer stay in the intensive care unit, SLKT recipients experienced significantly higher 1-year survival rate (90.5%) compared with LT recipients (60%, P=0.019). Multivariate regression analysis revealed that postoperative renal failure (odds ratio (OR)=48, P=0.003) and Risk/Injury/Failure/Loss/End-stage (RIFLE) stage (OR=8, P=0.012) were independent risk factors for postoperative death after LT.ConclusionsSLKT in patients with hepatitis B had higher early-stage infection rate, but had a higher long-term survival rate compared with the LT group. Although the incidence of postoperative hepatitis B relapse in SLKT recipients was higher, timely and reasonable treatment can ensure long-term survival of patients. Worsening RIFLE stage of recipients can predict high mortality when only given LT. SLKT might be a better choice for RIFLE stage 2 or 3 patients than LT alone.

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“…A Spanish group recently analyzed retrospectively the outcomes of 1265 isolated kidney transplantations and 1050 isolated liver transplantations, comparing the data with 34 subjects who received a CLKT (29 adults and five children) . The patient survival rate for those who received a CLKT was 91%, 51%, and 40%, at one, five, and 10 yr, respectively.…”

Section: Resultsmentioning

confidence: 99%

Review of combined liver and kidney transplantation in children

Ganschow

Höppe²

2015

Pediatric Transplantation

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In this review, we focused on CLKT with regard to indication, results, outcome, and future developments. PH1 is one of the most common diagnoses for adult and pediatric patients qualifying for CLKT. The other major indication for combined transplantation is ARPKD. CLKT appears to be superior to sequential liver and kidney transplantation in the majority of patients and overall results following CLKT are now good, even in small children. Clinical observations suggest that there is an immunological advantage of CLKT in comparison with isolated liver or kidney transplantation. More clinical studies are necessary to identify the best candidates for CLKT while the availability of donor organs is low.

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Combined Liver-Kidney Transplantation: Survey of a Single Center in Spain

Cited by 5 publications

References 19 publications

Untitled

Untitled

Long-Term Outcomes of Simultaneous Liver-Kidney Transplant Patients with Hepatitis B Compared to with Liver Transplant Alone

Review of combined liver and kidney transplantation in children

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