Combined liver radiation and chemotherapy for palliation of hepatic metastases from colorectal cancer.

Mohiuddin, Mohammed; Chen, Et-Tsu; Ahmad, Neelofur

doi:10.1200/jco.1996.14.3.722

Cited by 75 publications

(27 citation statements)

References 16 publications

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“…59 Improved local control and survival with higher doses of RT also have been observed by others, with no obvious correlation between dose and potential confounding factors, such as tumor size and performance status. 11,51,59,60 To our knowledge, the largest experience with RT in patients with HCC is from Asia, where sustained, long-term local control and survival have been reported in patients who received treatment with a variety of radiation fractionation schemes with conformal RT techniques. One-year survival rates in those patients ranges from 50% to 95%, and the 5-year survival rate ranges from 9% to 25% after 40 Gy to 60 Gy delivered over 1 to 5 weeks 6,55,[61][62][63] (Table 3).…”

Section: Conformal Rtmentioning

confidence: 99%

Radiation therapy for hepatocellular carcinoma

Hawkins

Dawson

2006

Cancer

221

171

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Technologic advances have provided the means to deliver tumoricidal doses of radiation therapy (RT) to patients with unresectable hepatocellular carcinoma (HCC) while avoiding critical normal tissues, providing the opportunity to use RT for curative intent treatment of HCC. For the current report, the expanded role of external beam RT in the setting of HCC from palliation to cure was reviewed. A systematic literature search was undertaken using the MEDLINE data base and secondary references to identify peer-reviewed, English-language articles that re- control response rates ranged from 40% to 90%, and the median survival ranges from 10 months to 25 months. For patients with HCC who had portal vein thrombus, the median survival after RT to treat the thrombus and/or the hepatic tumor with or without TACE ranged from 5.3 months to 9.7 months. Although outcomes after high-dose conformal RT for liver-confined HCC were excellent, the potential survival benefit of RT should be tested in randomized controlled trials that require international collaboration.

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Section: Conformal Rtmentioning

confidence: 99%

Radiation therapy for hepatocellular carcinoma

Hawkins

Dawson

2006

Cancer

221

171

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“…Occasionally, when treatment affects a number of symptoms, the individual symptoms are listed and their palliation reported [e.g. neurological symptoms in patients with brain metastases (Kurtz et al, 1981) or general symptoms resulting from hepatic metastases (Mohiuddin et al, 1996)]. …”

mentioning

confidence: 99%

Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise

Stephens¹,

Hopwood

Girling³

1999

Br J Cancer

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The assessment of symptom palliation is an essential component of many treatment comparisons in clinical trials, yet an extensive literature search revealed no consensus as to its precise definition, which could embrace relief of symptoms, time to their onset, duration, degree, as well as symptom control and prevention. In an attempt to assess the importance of these aspects and to compare different methods of analysis, we used one symptom (cough) from a patient self-assessment questionnaire (the Rotterdam Symptom Checklist) in a large (>300 patient) multicentre randomized clinical trial (conducted by the Medical Research Council Lung Cancer Working Party) of palliative chemotherapy in small-cell lung cancer. The regimens compared were a two-drug regimen (2D) and a four-drug regimen (4D). No differences were seen between the regimens in time of onset of palliation or its duration. The degree of palliation was strongly related to the initial severity: 90% of the patients with moderate or severe cough at baseline reported improvement, compared with only 53% of those with mild cough. Analyses using different landmark time points gave conflicting results: the 4D regimen was superior at 1 month and at 3 months, whereas at 2 months the 2D regimen appeared superior. When improvement at any time up to 3 months was considered, the 4D regimen showed a significant benefit (4D 79%, 2D 60%, P = 0.02). These findings emphasize the need for caution in interpreting results, and the importance of working towards a standard definition of symptom palliation. The current lack of specified criteria makes analysis and interpretation of trial results difficult, and comparison across trials impossible. A standard definition of palliation for use in the analysis of clinical trials data is proposed, which takes into account aspects of onset, duration and degree of palliation, and symptom improvement, control and prevention. © 1999 Cancer Research Campaign

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“…Fewer than 20% of patients may experience local recurrence 8,20,21 , and even if selection bias is believed to exist in the series data, the results of sbrt remain impressive. Our case also reflects the role played by the new imaging techniques and the importance of cea in managing crc.…”

Section: Discussionmentioning

confidence: 99%

Isolated Colorectal Liver Metastases Locally Progressing after Stereotactic Body Radiotherapy Rescued with Surgery

et al. 2009

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Treatment of patients with metastatic colorectal cancer has changed in recent years, with many patients now being offered intent-to-treat regimens. In this context, a multidisciplinary approach to the metastatic disease may lead to individualized treatment for any patient. Stereotactic body radiotherapy (sbrt) is not the most common treatment. Here, we present the clinical case of a patient with a solitary liver metastasis initially treated with sbrt that was rescued with surgery when a local recurrence was detected.

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Combined liver radiation and chemotherapy for palliation of hepatic metastases from colorectal cancer.

Cited by 75 publications

References 16 publications

Radiation therapy for hepatocellular carcinoma

Radiation therapy for hepatocellular carcinoma

Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise

Isolated Colorectal Liver Metastases Locally Progressing after Stereotactic Body Radiotherapy Rescued with Surgery

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